[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100475355":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":46,"responsibleParty":65,"collaborators":30,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":30,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":30,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":30,"overallStatus":48,"whyStopped":30,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Cinclus Pharma Holding AB","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Linaprazan glurate","EXPERIMENTAL","Oral administration as a single dose of 300 mg, 600 mg, 150 mg, 275 mg, and up to 2 additional dose levels.",[13],"Drug: Linaprazan glurate",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Oral administration as a singel dose",[19],"Drug: Placebo",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Linaprazan glurate base formulation, 25 mg oral tablets (300 mg and 600 mg doses).\n\nLinaprazan glurate hydrochloride (HCl), 25 mg and 50 mg (as base) oral tablets (150 mg, 275 mg and up to 2 additional dose levels).",[9],[26],"X842",{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Single dose, oral tablets",[15],null,[32],{"name":33,"affiliation":34,"role":35},"Erik Rein-Hedin, MD","CTC Clinical Trial Consultants AB","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":30,"email":41},"Sophie Leyman, MD","CONTACT","+32 470214020","sophie.leyman@cincluspharma.com",{"name":43,"role":39,"phone":44,"phoneExt":30,"email":45},"Kajsa Larsson, MD, PhD","+46 70 675 01 28","kajsa.larsson@cincluspharma.com",[47],{"facility":34,"status":48,"city":49,"state":30,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Uppsala","SE-75237","Sweden","SE",{"type":54,"coordinates":55},"Point",[56,57],17.63889,59.85882,{"lat":57,"lon":56},[60,64],{"name":61,"role":39,"phone":62,"phoneExt":30,"email":63},"Kristina Ocklind","+4618303300","kristina.ocklind@ctc-ab.se",{"name":33,"role":35,"phone":30,"phoneExt":30,"email":30},{"type":66,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100475355","phase-1-a-study-to-investigate-the-pharmacokinetics-and-ecg-effects-of-linaprazan-glurate-100475355",false,"NCT05469854","A Study to Investigate the Pharmacokinetics and ECG Effects of Linaprazan Glurate","A Phase I Trial to Investigate the Pharmacokinetics and ECG Effects of Single Doses of Linaprazan Glurate Administered as Oral Tablets to Healthy Participants","Main inclusion Criteria:\n\n1. Willing and able to give written informed consent for participation in the study.\n2. Healthy male or female aged 18 to 65 years\n3. Body mass index ≥18.5 and ≤35.0 kg\u002Fm2.\n4. Prospective subjects, as well as their partners, must agree to contraception requirements\n\nMain exclusion criteria:\n\n1. Female subjects of childbearing potential unless they agree to use highly effective methods of contraception (failure rate of \\\u003C1%) from 2 weeks prior to dosing until the end-of-study visit.\n2. Male subjects with a partner of childbearing potential, unless they agree to use method of contraception from 2 weeks prior to dosing until the end-of-study visit.History of or current clinically significant disease as defined in the protocol\n3. History of or current clinically significant disease as defined in the protocol.\n4. History of GERD, significant acid reflux.\n5. Subjects who are pregnant, currently breastfeeding, or intend to become pregnant (female subjects) or father a child (male subjects) during the course of the study (i.e., from screening to end of study visit).",true,"ALL","18 Years","65 Years",{"count":79,"type":80},121,"ESTIMATED","INTERVENTIONAL",[83],"PHASE1","This is a Phase I, single-center, double blind, placebo-controlled, parallel-group, randomized trial designed to evaluate the PK, cardiodynamic ECG effects, safety, and tolerability of single oral doses of linaprazan glurate. The trial will explore the PK properties of linaprazan glurate and linaprazan as well as the cardiodynamic ECG effects, safety, and tolerability after the administration of single doses: 300 mg and 600 mg in Part I of the trial, using formulation A of linaprazan glurate, as well as 150 mg, 275 mg, and up to 2 additional dose levels, using formulation C of linaprazan glurate to reach target linaprazan mean Cmax exposure (5222 nmol\u002FL).",[86,87,88,89],"Pharmacokinetics","Cardiodynamic ECG","Safety, and Tolerability","GERD","2026-06-15",{"date":92,"type":93},"2026-06-17","ACTUAL",{"date":95,"type":93},"2022-07-13",{"date":97,"type":80},"2026-11-30",{"name":5,"class":6},1]