[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555070":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":11,"centralContacts":44,"locations":50,"responsibleParty":482,"collaborators":11,"id":484,"slug":485,"hasResults":486,"nctId":487,"briefTitle":488,"officialTitle":489,"acronym":11,"eligibilityCriteria":490,"healthyVolunteers":486,"sex":491,"minAge":492,"maxAge":11,"enrollmentInfo":493,"targetDuration":11,"studyType":496,"phases":497,"briefSummary":499,"conditions":500,"keywords":11,"overallStatus":53,"whyStopped":11,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":503,"startDateStruct":506,"completionDateStruct":508,"leadSponsor":510,"locationsCount":511},{"fullName":5,"class":6},"Kumquat Biosciences Inc.","INDUSTRY",[8,14,19,22,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Monotherapy Dose Escalation","EXPERIMENTAL",null,[13],"Drug: KQB198",{"label":15,"type":10,"description":11,"interventionNames":16},"Combo Therapy Dose Escalation",[13,17,18],"Drug: Osimertinib","Drug: Amivantamab",{"label":20,"type":10,"description":11,"interventionNames":21},"Combo Therapy Dose Expansion - RP2D",[13,17,18],{"label":23,"type":10,"description":11,"interventionNames":24},"Combo Therapy Dose Expansion - RP2D-1",[13,17,18],{"label":26,"type":10,"description":11,"interventionNames":27},"Combo Therapy Dose Expansion OBD",[13,17,18],[29,34,40],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":11},"DRUG","KQB198","Oral KQB198",[15,20,23,26,9],{"type":30,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Osimertinib","Oral Osimertinib",[15,20,23,26],[39],"Tagrisso",{"type":30,"name":41,"description":42,"armGroupLabels":43,"otherNames":11},"Amivantamab","Subcutaneous administration",[15,20,23,26],[45],{"name":46,"role":47,"phone":48,"phoneExt":11,"email":49},"Kumquat Clinical Development","CONTACT","(858) 214-2700","kumquatstudies@kumquatbio.com",[51,70,85,100,115,129,144,159,170,183,198,214,230,240,254,268,284,293,304,314,323,329,345,355,365,374,388,398,408,419,432,445,457,467,476],{"facility":52,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Sarah Cannon Research Institute at HealthONE","RECRUITING","Denver","Colorado","80218","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-104.9847,39.73915,{"lat":63,"lon":62},[66],{"name":67,"role":47,"phone":68,"phoneExt":11,"email":69},"Shelby Mosier-Murray","720-754-7862","shelby.mosiermurray@sarahcannon.com",{"facility":71,"status":53,"city":72,"state":73,"zip":74,"country":57,"countryCode":58,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Sarah Cannon Research Institute at Florida Cancer Specialists - Lake Nona -","Orlando","Florida","32827",{"type":60,"coordinates":76},[77,78],-81.37924,28.53834,{"lat":78,"lon":77},[81],{"name":82,"role":47,"phone":83,"phoneExt":11,"email":84},"Ingrid Acker","904-380-2414","Ingrid.Acker@scri.com",{"facility":86,"status":53,"city":87,"state":73,"zip":88,"country":57,"countryCode":58,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Florida Cancer Specialists - Sarasota","Sarasota","34232",{"type":60,"coordinates":90},[91,92],-82.53065,27.33643,{"lat":92,"lon":91},[95],{"name":96,"role":47,"phone":97,"phoneExt":98,"email":99},"Mallory Hawkins","941-377-9993","21654","Mallory.Hawkins@flcancer.com",{"facility":101,"status":53,"city":102,"state":103,"zip":104,"country":57,"countryCode":58,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"Henry Ford Health System","Detroit","Michigan","48202",{"type":60,"coordinates":106},[107,108],-83.04575,42.33143,{"lat":108,"lon":107},[111],{"name":112,"role":47,"phone":113,"phoneExt":11,"email":114},"Jeevana Koneru","313-725-7857","jkoneru2@hfhs.org",{"facility":116,"status":53,"city":117,"state":118,"zip":119,"country":57,"countryCode":58,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"David H. Koch Center for Cancer Center at Memorial Sloan Kettering Cancer Center","Long Island City","New York","11101",{"type":60,"coordinates":121},[122,123],-73.94875,40.74482,{"lat":123,"lon":122},[126],{"name":127,"role":47,"phone":11,"phoneExt":11,"email":128},"Navkaran Singh","singhn10@mskcc.org",{"facility":130,"status":53,"city":131,"state":132,"zip":133,"country":57,"countryCode":58,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"The Lindner Center for Research and Education at The Christ Hospital","Cincinnati","Ohio","45219",{"type":60,"coordinates":135},[136,137],-84.51439,39.12711,{"lat":137,"lon":136},[140],{"name":141,"role":47,"phone":142,"phoneExt":11,"email":143},"Abby Reed","513-585-1140","abby.reed@thechristhospital.com",{"facility":145,"status":53,"city":146,"state":147,"zip":148,"country":57,"countryCode":58,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"Sarah Cannon and HCA Research Institute","Nashville","Tennessee","37203",{"type":60,"coordinates":150},[151,152],-86.78444,36.16589,{"lat":152,"lon":151},[155],{"name":156,"role":47,"phone":157,"phoneExt":11,"email":158},"Derrick Porter","619-982-4133","Derrick.porter@scri.com",{"facility":160,"status":161,"city":162,"state":163,"zip":164,"country":57,"countryCode":58,"cosmosGeoPoint":165,"geoPoint":169,"contacts":11},"MD Anderson Cancer Center","WITHDRAWN","Houston","Texas","77030",{"type":60,"coordinates":166},[167,168],-95.36327,29.76328,{"lat":168,"lon":167},{"facility":171,"status":53,"city":172,"state":163,"zip":173,"country":57,"countryCode":58,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"New Experimental Therapeutics of San Antonio - NEXT Oncology","San Antonio","78229",{"type":60,"coordinates":175},[176,177],-98.49363,29.42412,{"lat":177,"lon":176},[180],{"name":181,"role":47,"phone":11,"phoneExt":11,"email":182},"Steven Alvarado","salvarado@nextoncology.com",{"facility":184,"status":53,"city":185,"state":186,"zip":187,"country":57,"countryCode":58,"cosmosGeoPoint":188,"geoPoint":192,"contacts":193},"New Experimental Therapeutics of Virginia - NEXT Oncology","Fairfax","Virginia","22031",{"type":60,"coordinates":189},[190,191],-77.30637,38.84622,{"lat":191,"lon":190},[194],{"name":195,"role":47,"phone":196,"phoneExt":11,"email":197},"Aber Lopez","703-565-2881","AmberLopez@nextoncology.com",{"facility":199,"status":53,"city":200,"state":201,"zip":202,"country":203,"countryCode":204,"cosmosGeoPoint":205,"geoPoint":209,"contacts":210},"Institut Paoli-Calmettes","Marseille","Bouches-du-Rhône","13009","France","FR",{"type":60,"coordinates":206},[207,208],5.38107,43.29695,{"lat":208,"lon":207},[211],{"name":212,"role":47,"phone":11,"phoneExt":11,"email":213},"Roqiya Nouar","nouarr@ipc.unicancer.fr",{"facility":215,"status":53,"city":216,"state":217,"zip":218,"country":203,"countryCode":204,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"Institut de Cancerologie de l'Ouest - site St-Herblain","Saint-Herblain","Loire-Atlantique","44800",{"type":60,"coordinates":220},[221,222],-1.651,47.21154,{"lat":222,"lon":221},[225],{"name":226,"role":47,"phone":227,"phoneExt":228,"email":229},"Emilie Toueni","+33 (0)2.40.67.99.00","9508","Emilie.Toueni@ico.unicancer.fr",{"facility":231,"status":53,"city":232,"state":233,"zip":234,"country":203,"countryCode":204,"cosmosGeoPoint":235,"geoPoint":239,"contacts":11},"CHU Bordeaux - Hopital Saint-Andre","Bordeaux","Nouvelle-Aquitane","33000",{"type":60,"coordinates":236},[237,238],-0.58046,44.84124,{"lat":238,"lon":237},{"facility":241,"status":53,"city":242,"state":243,"zip":244,"country":203,"countryCode":204,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"IUCT-Oncopole","Toulouse","Occitaine","31059",{"type":60,"coordinates":246},[247,248],1.44367,43.60426,{"lat":248,"lon":247},[251],{"name":252,"role":47,"phone":11,"phoneExt":11,"email":253},"Guerin Frederic","Guerin.Frederic@iuct-oncopole.fr",{"facility":255,"status":53,"city":256,"state":257,"zip":258,"country":203,"countryCode":204,"cosmosGeoPoint":259,"geoPoint":263,"contacts":264},"CHU de Nantes - Hopital Nord Laennec","Nantes","Pays de la Loire Region","44000",{"type":60,"coordinates":260},[261,262],-1.55336,47.21725,{"lat":262,"lon":261},[265],{"name":266,"role":47,"phone":11,"phoneExt":11,"email":267},"Lucie Ndiaye","lucie.groisard@chu-nantes.fr",{"facility":269,"status":53,"city":270,"state":271,"zip":272,"country":273,"countryCode":274,"cosmosGeoPoint":275,"geoPoint":279,"contacts":280},"Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore","Rome","Lazio","00168","Italy","IT",{"type":60,"coordinates":276},[277,278],12.51133,41.89193,{"lat":278,"lon":277},[281],{"name":282,"role":47,"phone":11,"phoneExt":11,"email":283},"Francesco Paroni Sterbini","francesco.paronisterbini@policlinicogemelli.it",{"facility":285,"status":53,"city":286,"state":11,"zip":287,"country":273,"countryCode":274,"cosmosGeoPoint":288,"geoPoint":292,"contacts":11},"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","Naples","80131",{"type":60,"coordinates":289},[290,291],14.26811,40.85216,{"lat":291,"lon":290},{"facility":294,"status":161,"city":295,"state":296,"zip":297,"country":298,"countryCode":11,"cosmosGeoPoint":299,"geoPoint":303,"contacts":11},"National Cancer Center","Goyang-si","Gyeonggi-do","10408","South Korea",{"type":60,"coordinates":300},[301,302],126.835,37.65639,{"lat":302,"lon":301},{"facility":305,"status":161,"city":306,"state":307,"zip":308,"country":298,"countryCode":11,"cosmosGeoPoint":309,"geoPoint":313,"contacts":11},"Chonnam National University Hwasun Hospital","Hwasun","Jeollanam-do","58128",{"type":60,"coordinates":310},[311,312],126.98746,35.06125,{"lat":312,"lon":311},{"facility":315,"status":161,"city":316,"state":11,"zip":317,"country":298,"countryCode":11,"cosmosGeoPoint":318,"geoPoint":322,"contacts":11},"Severance Hospital, Yonsei University Health System","Seoul","03722",{"type":60,"coordinates":319},[320,321],126.9784,37.566,{"lat":321,"lon":320},{"facility":324,"status":161,"city":316,"state":11,"zip":325,"country":298,"countryCode":11,"cosmosGeoPoint":326,"geoPoint":328,"contacts":11},"Seoul St. Mary's Hospital, The Catholic University of Korea","06591",{"type":60,"coordinates":327},[320,321],{"lat":321,"lon":320},{"facility":330,"status":53,"city":331,"state":332,"zip":333,"country":334,"countryCode":335,"cosmosGeoPoint":336,"geoPoint":340,"contacts":341},"Hospital Universitari Quiron Dexeus Barcelona","Barcelona","Catalonia","08028","Spain","ES",{"type":60,"coordinates":337},[338,339],2.15899,41.38879,{"lat":339,"lon":338},[342],{"name":343,"role":47,"phone":11,"phoneExt":11,"email":344},"Marina Garcia Prat","mgarcia@oncorosell.com",{"facility":346,"status":53,"city":331,"state":332,"zip":347,"country":334,"countryCode":335,"cosmosGeoPoint":348,"geoPoint":350,"contacts":351},"Hospital Universitario Vall d'Hebron","08035",{"type":60,"coordinates":349},[338,339],{"lat":339,"lon":338},[352],{"name":353,"role":47,"phone":11,"phoneExt":11,"email":354},"Paula Barranco","paulabarranco@vhio.net",{"facility":356,"status":53,"city":331,"state":11,"zip":357,"country":334,"countryCode":335,"cosmosGeoPoint":358,"geoPoint":360,"contacts":361},"New Experimental Therapeutics (NEXT) Oncology Barcelona","08023",{"type":60,"coordinates":359},[338,339],{"lat":339,"lon":338},[362],{"name":363,"role":47,"phone":11,"phoneExt":11,"email":364},"Abigail Huerta","ahuerta@nextoncology.eu",{"facility":366,"status":53,"city":331,"state":11,"zip":357,"country":334,"countryCode":335,"cosmosGeoPoint":367,"geoPoint":369,"contacts":370},"South Texas Accelerated Research Therapeutics (START) Barcelona- HM Nou Delfos",{"type":60,"coordinates":368},[338,339],{"lat":339,"lon":338},[371],{"name":372,"role":47,"phone":11,"phoneExt":11,"email":373},"Rodolfo Fuentes","rodolfo.fuentes@start-barcelona.com",{"facility":375,"status":53,"city":376,"state":11,"zip":377,"country":334,"countryCode":335,"cosmosGeoPoint":378,"geoPoint":382,"contacts":383},"Hospital Universitario Ramon y Cajal","Madrid","28034",{"type":60,"coordinates":379},[380,381],-3.70256,40.4165,{"lat":381,"lon":380},[384],{"name":385,"role":47,"phone":386,"phoneExt":11,"email":387},"Asier Artazcoz","913368905","artazcozec@gmail.com",{"facility":389,"status":53,"city":376,"state":11,"zip":390,"country":334,"countryCode":335,"cosmosGeoPoint":391,"geoPoint":393,"contacts":394},"South Texas Accelerated Research Therapeutics (START) Madrid - CIOCC","28040",{"type":60,"coordinates":392},[380,381],{"lat":381,"lon":380},[395],{"name":396,"role":47,"phone":11,"phoneExt":11,"email":397},"Silvia Garcia Cuadrado","Silvia.GarciaCuadrado@startmadrid.com",{"facility":399,"status":53,"city":376,"state":11,"zip":400,"country":334,"countryCode":335,"cosmosGeoPoint":401,"geoPoint":403,"contacts":404},"New Experimental Therapeutics (NEXT) Oncology Madrid - Hospital Quironsalud Madrid","28223",{"type":60,"coordinates":402},[380,381],{"lat":381,"lon":380},[405],{"name":406,"role":47,"phone":11,"phoneExt":11,"email":407},"Pierpaolo Pisanu","ppisanu@nextoncology.eu",{"facility":409,"status":53,"city":376,"state":11,"zip":11,"country":334,"countryCode":335,"cosmosGeoPoint":410,"geoPoint":412,"contacts":413},"South Texas Accelerated Research Therapeutics (START) Madrid - Hospital Fundacion Jimenez Diaz",{"type":60,"coordinates":411},[380,381],{"lat":381,"lon":380},[414],{"name":415,"role":47,"phone":416,"phoneExt":417,"email":418},"Maria Conesa Garcia-Vera","0034915504800","2201","maria.conesa@startmadrid.com",{"facility":420,"status":53,"city":421,"state":11,"zip":422,"country":334,"countryCode":335,"cosmosGeoPoint":423,"geoPoint":427,"contacts":428},"Hospital Quirónsalud Málaga","Málaga","29004",{"type":60,"coordinates":424},[425,426],-4.42034,36.72016,{"lat":426,"lon":425},[429],{"name":430,"role":47,"phone":11,"phoneExt":11,"email":431},"Irene Fernandez","irene.fernandezb.co@quironsalud.es",{"facility":433,"status":53,"city":434,"state":11,"zip":435,"country":334,"countryCode":335,"cosmosGeoPoint":436,"geoPoint":440,"contacts":441},"Clinica Universidad de Navarra - Pamplona","Pamplona","31008",{"type":60,"coordinates":437},[438,439],-1.64323,42.81687,{"lat":439,"lon":438},[442],{"name":443,"role":47,"phone":11,"phoneExt":11,"email":444},"Eduardo de la Guardia","edelaguardia@unav.es",{"facility":446,"status":161,"city":447,"state":448,"zip":449,"country":450,"countryCode":451,"cosmosGeoPoint":452,"geoPoint":456,"contacts":11},"Chi-Mei Hospital - Liouying Branch","Liuying","Tainan City","73657","Taiwan","TW",{"type":60,"coordinates":453},[454,455],118.3877,24.44719,{"lat":455,"lon":454},{"facility":458,"status":161,"city":459,"state":460,"zip":461,"country":450,"countryCode":451,"cosmosGeoPoint":462,"geoPoint":466,"contacts":11},"National Taiwan University Hospital","Taipei","Taipei City","100225",{"type":60,"coordinates":463},[464,465],121.52639,25.05306,{"lat":465,"lon":464},{"facility":468,"status":161,"city":469,"state":11,"zip":470,"country":450,"countryCode":451,"cosmosGeoPoint":471,"geoPoint":475,"contacts":11},"Taichung Veterans General Hospital","Taichung","40705",{"type":60,"coordinates":472},[473,474],120.6839,24.1469,{"lat":474,"lon":473},{"facility":477,"status":161,"city":459,"state":11,"zip":478,"country":450,"countryCode":451,"cosmosGeoPoint":479,"geoPoint":481,"contacts":11},"Taipei Veterans General Hospital","11217",{"type":60,"coordinates":480},[464,465],{"lat":465,"lon":464},{"type":483,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100555070","phase-1-a-study-to-investigate-the-safety-and-efficacy-of-kqb198-as-monotherapy-and-in-combination-in-participants-with-advanced-solid-malignancies-100555070",false,"NCT06507306","A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies","A Phase 1\u002F1b, Open-label, Multicenter, Dose Escalation and Dose Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of KQB198 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies","Inclusion Criteria:\n\n* PART 1 - Histologically confirmed diagnosis of a solid tumor malignancy with any of the following oncogenic mutations: EGFR, RAS, PTPN11, or SOS1 mutations, or inactivating mutations of NF1.\n* PART 1 - (Osimertinib and Amivantamab arms) and Part 2 Cohort A and Cohort B: Histologically confirmed diagnosis of NSCLC with activating EGFR mutation and progression on osimertinib\n* Part 3 - Cohort A: Histologically confirmed diagnosis of NSCLC with exon 20 insertion EGFR mutation\n* Unresectable or metastatic disease\n* No available treatment with curative intent\n* Adequate organ function\n* Measurable disease per RECIST 1.1.\n\nExclusion Criteria:\n\n* Prior therapy with a similar mechanism of action to KQB198\n* History of intestinal disease, inflammatory bowel disease, major gastric surgery, or other gastrointestinal conditions likely to alter absorption of study treatment or result in inability to swallow\n* History of interstitial lung disease\n* Cardiac abnormalities","ALL","18 Years",{"count":494,"type":495},100,"ESTIMATED","INTERVENTIONAL",[498],"PHASE1","The goal of this clinical trial is to learn if KQB198 works to treat advanced solid tumor cancer in adults. It will also learn about the safety of KQB198. The main questions it aims to answer are:\n\n* What is the safe dose of KQB198 by itself or in combination with other anti-cancer drugs?\n* Does KQB198 alone or in combination with other anti-cancer drugs decrease the size of the tumor?\n* What happens to KQB198 in the body?\n\nParticipants will:\n\n* Take KQB198 daily, alone or in combination with another anti-cancer drug\n* Visit the clinic about 8 times in the first 8 weeks, and then once every 4 weeks after that",[501],"Solid Tumor, Adult","2026-02-04",{"date":504,"type":505},"2026-02-06","ACTUAL",{"date":507,"type":505},"2024-06-03",{"date":509,"type":495},"2027-01-31",{"name":5,"class":6},35]