[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641325":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":30,"centralContacts":34,"locations":42,"responsibleParty":57,"collaborators":29,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":29,"enrollmentInfo":69,"targetDuration":29,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":29,"overallStatus":45,"whyStopped":29,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Hoffmann-La Roche","INDUSTRY",[8,14,17,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1","EXPERIMENTAL","Participants will receive RO7663498.",[13],"Drug: RO7663498",{"label":15,"type":10,"description":11,"interventionNames":16},"Cohort 2",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Cohort 3",[13],{"label":21,"type":10,"description":11,"interventionNames":22},"Cohort 4",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DRUG","RO7663498","Participants will receive RO7663498 as per the schedule defined in the protocol.",[9,15,18,21],null,[31],{"name":32,"affiliation":5,"role":33},"Clinical Trials","STUDY_DIRECTOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":29,"email":39},"Reference Study ID Number: BP46156 https:\u002F\u002Fforpatients.roche.com\u002F No email attachments.","CONTACT","888-662-6728 (U.S. Only)","global-roche-genentech-trials@gene.com",{"name":41,"role":37,"phone":29,"phoneExt":29,"email":29},"Fastest response: use the inquiry form. https:\u002F\u002Fwww.gene.com\u002Fcontact-us\u002Fsubmit-medical-inquiry",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":29},"Global Research Management","RECRUITING","Glendale","California","91204","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-118.25508,34.14251,{"lat":55,"lon":54},{"type":58,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100641325","phase-1-a-study-to-investigate-the-safety-tolerability-and-pharmacokinetics-of-ro7663498-following-intravitreal-administration-in-participants-with-diabetic-retinopathy-100641325",false,"NCT07588100","A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy","A Multicenter, Non-Randomized, Open-Label, Multiple-Ascending-Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy","CENOTE","Inclusion Criteria:\n\nGeneral Inclusion Criteria\n\n* Diagnosis of Diabetes Mellitus (DM) (Type 1 or Type 2), as defined by the World Health Organization and\u002For American Diabetes Association\n\nOcular Inclusion Criteria for the Study Eye\n\n* BCVA score at screening of \\>= 19 letters in study eye using Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity testing charts\n* Non-proliferative diabetic retinopathy (NPDR) as assessed by the investigator and confirmed by the Central reading center (CRC)\n* Collection of \\>= 90 micro liter (μL) AH deemed feasible and safe by the investigator.\n\nExclusion Criteria:\n\nGeneral Exclusion Criteria:\n\n* Any known hypersensitivity to any of the following compounds: fluorescein; any dilating, anesthetic, or povidone iodine eye drops; or any excipients contained in the treatments used in this study.\n* History of hypersensitivity to biologic agents, the investigational drug, or any of the excipients contained in the formulation administered IVT or systemically.\n\nOcular Exclusion Criteria for the Study Eye\n\n* Center-involved Diabetic Macular Edema (DME)\n* Any history or concurrent ocular conditions\u002Fprocedures and\u002For visual system conditions of the below.\n* Vitreoretinal surgery\u002Fpars plana vitrectomy.\n* Any history of glaucoma surgery or planned glaucoma surgery during the study.\n* Uncontrolled glaucoma\n* Anterior segment neovascularization.\n* Vitreous or preretinal hemorrhage.\n* Any ocular disease other than DR and DME that may Confound assessment of the retina in the opinion of the investigator or Confound development of worsening DR, DME, or retinal nonperfusion.\n* Any presence of active intraocular inflammation on Day 1 (i.e., Standardization of Uveitis Nomenclature \\[SUN\\] criteria \\> 0 or National Eye Institute \\[NEI\\] vitreous haze grading \\> 0) or any history of IOI.\n* Aphakia or previous violation of the posterior capsule in the study eye\n\nOcular Exclusion Criteria for the Non-study Eye\n\n* BCVA \\\u003C 38 letters","ALL","18 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"PHASE1","This study will assess the safety, tolerability, and pharmacokinetics (PK) of intravitreal (IVT) injections of RO7663498 in participants with diabetic retinopathy (DR).",[77],"Diabetic Retinopathy","2026-06-19",{"date":80,"type":81},"2026-06-23","ACTUAL",{"date":83,"type":81},"2026-06-18",{"date":85,"type":71},"2027-12-30",{"name":5,"class":6},1]