[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627993":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":44,"responsibleParty":84,"collaborators":33,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":33,"eligibilityCriteria":92,"healthyVolunteers":88,"sex":93,"minAge":94,"maxAge":33,"enrollmentInfo":95,"targetDuration":33,"studyType":98,"phases":99,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":47,"whyStopped":33,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Regeneron Pharmaceuticals","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"REGN17372 + Linvoseltamab","EXPERIMENTAL","Phase 1 Phase 2",[13],"Drug: REGN17372+Linvoseltamab",{"label":15,"type":16,"description":17,"interventionNames":18},"Linvoseltamab monotherapy","ACTIVE_COMPARATOR","Phase 2",[19],"Drug: Linvoseltamab",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Linvoseltamab","Administered per protocol",[15],[27,28],"Lynozyfic™","REGN5458",{"type":22,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"REGN17372+Linvoseltamab","Administered per the protocol",[9],null,[35],{"name":36,"affiliation":5,"role":37},"Clinical Trial Management","STUDY_DIRECTOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":33,"email":43},"Clinical Trials Administrator","CONTACT","844-734-6643","clinicaltrials@regeneron.com",[45,59,68,78],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":33},"Prince of Wales Hospital","RECRUITING","Randwick","New South Wales","2031","Australia","AU",{"type":54,"coordinates":55},"Point",[56,57],151.24895,-33.91439,{"lat":57,"lon":56},{"facility":60,"status":47,"city":61,"state":49,"zip":62,"country":51,"countryCode":52,"cosmosGeoPoint":63,"geoPoint":67,"contacts":33},"Illawarra Cancer care centre, Wollongong Hospital","Wollongong","2500",{"type":54,"coordinates":64},[65,66],150.89345,-34.424,{"lat":66,"lon":65},{"facility":69,"status":47,"city":70,"state":71,"zip":72,"country":51,"countryCode":52,"cosmosGeoPoint":73,"geoPoint":77,"contacts":33},"Peter MacCallum Cancer Centre","Melbourne","Victoria","3000",{"type":54,"coordinates":74},[75,76],144.96332,-37.814,{"lat":76,"lon":75},{"facility":79,"status":47,"city":70,"state":71,"zip":80,"country":51,"countryCode":52,"cosmosGeoPoint":81,"geoPoint":83,"contacts":33},"Alfred Hospital","3004",{"type":54,"coordinates":82},[75,76],{"lat":76,"lon":75},{"type":85,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100627993","phase-1-a-trial-to-study-if-regn17372-in-combination-with-linvoseltamab-is-tolerable-for-adult-participants-with-relapsedrefractory-multiple-myeloma-100627993",false,"NCT07455851","A Trial to Study if REGN17372 in Combination With Linvoseltamab is Tolerable for Adult Participants With Relapsed\u002FRefractory Multiple Myeloma","A FIH Phase 1\u002F2 Study to Assess Safety, Tolerability, and Preliminary Anti-Tumor Activity of REGN17372, an Anti-GPRC5D x Anti-CD28 Costimulatory Bispecific Monoclonal Antibody, in Combination With Linvoseltamab, an Anti-BCMA x Anti-CD3 Bispecific Monoclonal Antibody, in Participants With Relapsed\u002FRefractory Multiple Myeloma","Key Inclusion Criteria:\n\n1. Participants with RRMM who have exhausted (or are not a candidate for) all therapeutic options that are expected to provide meaningful clinical benefit and have received at least 3 lines of therapy as defined in the protocol\n2. ECOG performance status score ≤1\n3. Participants must have measurable disease for response assessment as described in the protocol\n4. Adequate hematologic, cardiac, hepatic, and renal function, as described in the protocol\n\nKey Exclusion Criteria:\n\n1. Participants with non-secretory MM, active plasma cell leukemia, known amyloidosis, Waldenström macroglobulinemia, or known POEMS syndrome as defined in the protocol\n2. Participants who have known MM brain lesions or CNS involvement\n3. Participants with a history of PML, a neurocognitive condition or CNS movement disorder, or a history of seizure within 12 months prior to entering screening\n4. Prior treatment with GPRC5D-directed immunotherapies (phase 1 and phase 2) and\u002For prior treatment with a BCMAxCD3 bispecific antibody (phase 2)\n\nNote: Other protocol defined inclusion\u002Fexclusion criteria apply","ALL","18 Years",{"count":96,"type":97},150,"ESTIMATED","INTERVENTIONAL",[100,101],"PHASE1","PHASE2","This study is researching a drug called REGN17372 used with another drug called linvoseltamab (each individually called \"study drug\" or \"study drugs\" when combined) in participants with relapsed (when a tumor comes back) or refractory (when a tumor does not respond to treatment) multiple myeloma. This study is the first time REGN17372 will be given to humans.\n\nThe aim of the study is to understand if REGN17372 can be given safely with linvoseltamab, and if so, what dosing regimen should be used for this treatment combination, in comparison with linvoseltamab alone.\n\nThe study is looking at:\n\n* What side effects may happen from taking REGN17372 with linvoseltamab\n* How well REGN17372 and linvoseltamab, or linvoseltamab alone, work in treating multiple myeloma\n* What is the best dose of REGN17372 when given with linvoseltamab\n* How much study drug(s) are in the blood at different times\n* Whether the body makes antibodies against the study drugs (which could make the study drugs less effective or could lead to side effects)\n* If and how REGN17372 and linvoseltamab affect the overall quality of life, daily activities, symptoms and treatment side effects based on participant own feedback (Phase 2)",[104],"Relapsed Refractory Multiple Myeloma (RRMM)",[106,107,108],"B-cell maturation antigen (BCMA)","Anti-CD3 monoclonal antibodies (mAbs)","G-protein-coupled receptor class C group 5 member D (GPRC5D)","2026-06-17",{"date":111,"type":112},"2026-06-18","ACTUAL",{"date":114,"type":112},"2026-03-26",{"date":116,"type":97},"2033-09-30",{"name":5,"class":6},4]