[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588955":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":37,"centralContacts":44,"locations":53,"responsibleParty":68,"collaborators":71,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":30,"enrollmentInfo":85,"targetDuration":30,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":30,"overallStatus":56,"whyStopped":30,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Yale University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Delta-9-THC Very Low Dose","ACTIVE_COMPARATOR","Active delta-9-THC administered intravenously over 20 minutes.",[13],"Drug: Delta-9-THC Low Dose",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Control: Small amount of alcohol administered intravenously (quarter teaspoon), with no delta-9-THC, over 20 minutes.",[19],"Drug: Placebo",{"label":21,"type":10,"description":11,"interventionNames":22},"Delta-9-THC Medium Dose",[23],"Drug: Delta-9-THC Medium Dose",[25,31,34],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Delta-9-THC Low Dose","Active Delta-9-THC administered intravenously over 20 minutes.",[9],null,{"type":26,"name":15,"description":32,"armGroupLabels":33,"otherNames":30},"Small amount of sterile ethanol (1-2 mLs), with no THC, administered intravenously over 20 minutes.",[15],{"type":26,"name":21,"description":35,"armGroupLabels":36,"otherNames":30},"Active Delta-9-THC administered intravenously over 20 minutes",[21],[38,42],{"name":39,"affiliation":40,"role":41},"Deepak C D'Souza, MD","Yale University School of Medicine; VA Connecticut Healthcare System","PRINCIPAL_INVESTIGATOR",{"name":43,"affiliation":40,"role":41},"Ashley Schnakenberg Martin, PhD",[45,51],{"name":46,"role":47,"phone":48,"phoneExt":49,"email":50},"Deepak C D'Souza","CONTACT","203-932-5711","12594","deepak.douza@yale.edu",{"name":43,"role":47,"phone":30,"phoneExt":30,"email":52},"ashley.martin@yale.edu",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":30},"VA Connecticut Healthcare System","RECRUITING","West Haven","Connecticut","06516","United States","US",{"type":63,"coordinates":64},"Point",[65,66],-72.94705,41.27065,{"lat":66,"lon":65},{"type":41,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Deepak C. D'Souza","Professor of Psychiatry",[72],{"name":73,"class":74},"National Institute on Drug Abuse (NIDA)","NIH","100588955","phase-1-acute-effects-of-thc-in-older-adult-100588955",false,"NCT06948136","Acute Effects of THC in Older Adult","THC-Aging","* Ability to provide informed consent\n* No history (current or past) of unstable or serious medical, neurological or psychiatric conditions.\n* High school education or greater\n* No positive pregnancy test and\u002For lactation\u002F planning to nurse while in this study\n* English speaking",true,"ALL","21 Years",{"count":86,"type":87},60,"ESTIMATED","INTERVENTIONAL",[90],"PHASE1","The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \\> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \\[P300\\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.",[93],"Age-related Cognitive Decline","2025-08-14",{"date":96,"type":97},"2025-08-18","ACTUAL",{"date":99,"type":97},"2025-06-06",{"date":101,"type":87},"2027-11-01",{"name":5,"class":6},1]