[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544122":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":34,"responsibleParty":52,"collaborators":20,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":20,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":20,"studyType":67,"phases":68,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":36,"whyStopped":20,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Children's Hospital of Philadelphia","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"beta thalassemia","EXPERIMENTAL","This arm will evaluate the safety and efficacy of infusing autologous hematopoietic stem and progenitor cells (HSPC) transduced with the novel lentiviral vector ALS20 that encodes the human βA-T87Q-globin gene, following myeloablative conditioning with busulfan.",[13],"Biological: ALS20",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BIOLOGICAL","ALS20","novel lentiviral vector ALS20",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Janet Kwiatkowski, MD","PRINCIPAL_INVESTIGATOR",[26,30],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","215-590-5286","kwiatkowski@chop.edu",{"name":31,"role":27,"phone":32,"phoneExt":20,"email":33},"Jaladhikumar Patel","267-426-5602","patelj23@chop.edu",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Philadelphia","Pennsylvania","19104","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-75.16362,39.95238,{"lat":46,"lon":45},[49,50,51],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},{"name":31,"role":27,"phone":32,"phoneExt":20,"email":33},{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":53,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100544122","phase-1-als20-101-lentiviral-gene-therapy-for-beta-thalassemia-100544122",false,"NCT06364774","ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia","Phase 1\u002F2 Study Evaluating the Safety and Efficacy of Gene Therapy Employing Lentiviral Vector ALS20-transduced Hematopoietic Progenitor Cells in Subjects With Transfusion-dependent-thalassemia","Inclusion Criteria:\n\n1. Age 18 to \\\u003C 40 years at the time of consent\n2. Diagnosis of transfusion dependent beta thalassemia (β0 β0, β+β0, β+β+, βEβ0, βEβ+,β0 or β+ \u002FβA + alpha triplication(s)). Transfusion-dependent is defined as a history of receiving at least 120 mL\u002Fkg\u002Fyear packed red blood cells or at least 8 transfusions per year in the past two years. The first 2 subjects enrolled must have a non- β0 β0 genotype.\n3. Genetic confirmation of α and β thalassemia diagnosis (β0β0, β+β0, β+β+, βEβ0, βEβ+, β0 or β+ \u002FβA + alpha triplication(s)) by a Clinical Laboratory Improvement Amendments (CLIA) certified laboratory is required.\n4. Clinically stable, Karnofsky score at least 70, and eligible to undergo Hematopoietic Stem Cell Transplantation (HSCT).\n5. Female subjects of childbearing potential must agree to use acceptable method(s) of contraception from consent through at least 6 months after CHOP-ALS20 infusion\n6. Male subjects of reproductive capacity must agree to use effective contraception from start of mobilization through at least 6 months after CHOP-ALS20 infusion\n7. All potential treatment options including allogeneic HSCT (HLA-matched related, HLA-matched unrelated, and haploidentical) as well as FDA approved gene therapy options have been thoroughly discussed with the independent hematologist and\u002For transplant physician and subject agrees to proceed with this clinical trial.\n\nExclusion Criteria:\n\n1. Prior receipt of HSCT or gene therapy\n2. More than one alpha globin gene deletions\u002Fmutations.\n3. Any prior or current malignancy (excluding adequately treated basal or squamous cell carcinoma of the skin)\n4. Known cancer predisposition syndrome\n5. Positive for HIV-1, HIV-2, Human T Cell Lymphotropic Virus-1,2 (HTLV-1, HTLV-2) or active hepatitis B or active hepatitis C infection\n6. Clinically significant active bacterial, viral (including COVID-19 and influenza), fungal, or parasitic infection (temporary exclusion)\n7. Clinically significant bleeding disorder\n8. Evidence of cardiac dysfunction (left ventricular ejection fraction \\\u003C50% or shortening fraction \\\u003C27%) or clinically significant arrhythmia\n9. Evidence of advanced liver disease (ALT \\>5x the upper limit of normal (ULN), prothrombin time \\>1.5 x ULN, direct bilirubin \\> 3x ULN) not attributable to iron chelation therapy, or evidence of bridging fibrosis on liver biopsy or fibrosis stage of F3 or higher by magnetic resonance elastography (MRE) if obtained as part of clinical care\n10. Liver R2 or R2 MRI or liver biopsy with liver iron concentration 15 mg\u002Fg dw (temporary exclusion)\n11. Diffusion capacity of the lungs for carbon monoxide (DLco) \\\u003C50% of predicted (corrected for Hb)\n12. Pulse oximetry in room air \\\u003C92%\n13. Evidence of renal dysfunction (creatinine \\>1.5x ULN or Glomerular Filtration Rate (GFR) \\\u003C70 ml\u002Fmin\u002F1.73 m2 based on cystatin C\u002Fcreatinine equation)\n14. Cardiac T2 MRI \\\u003C 10 ms\n15. Platelet count \\\u003C100,000\u002FmcL or absolute neutrophil count \\\u003C1000\u002FmcL except if attributed to benign ethnic neutropenia\n16. Unable to receive red cell transfusion (significant allo\u002Fauto immunization)\n17. Uncontrolled systemic hypertension\n18. Uncontrolled seizure disorder\n19. Diagnosis of a significant psychiatric disorder that could seriously impede the ability to participate in the study as determined by the investigator\n20. Immediate family member with a known or suspected Familial Cancer Syndrome\n21. Contraindication to anesthesia\n22. For female subjects, pregnancy or breastfeeding\n23. Participation in another clinical trial of an investigational drug within 30 days or 5 drug half-lives, whichever is longer, of screening (temporary exclusion)\n24. Any other condition that would render the subject ineligible for mobilization\u002Fapheresis and\u002For HSCT as determined by the investigator","ALL","18 Years","40 Years",{"count":65,"type":66},12,"ESTIMATED","INTERVENTIONAL",[69,70],"PHASE1","PHASE2","The main goal of this study is to find out if the blood disorder called transfusion-dependent beta thalassemia can be safely treated by modifying blood stem cells. This is done by collecting blood stem cells from the subject, modifying those cells, adding a healthy beta globin gene, and then giving them back to the subject. It is hoped that these modified cells will decrease the need for blood transfusions. The gene modified blood stem cells are called CHOP-ALS20 (\"study drug\"). This experimental gene therapy has not been tried on human beings before and is not FDA approved.",[73],"Beta-Thalassemia",[75,76,77,78],"Thalassemia","Beta Thalassemia","gene therapy","beta globin gene","2026-04-13",{"date":81,"type":82},"2026-04-15","ACTUAL",{"date":84,"type":82},"2025-04-14",{"date":86,"type":66},"2027-12-31",{"name":5,"class":6},1]