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Participants without archived tumor tissue may enroll by undergoing tumor biopsy before dosing.\n* Disease measurable as defined by Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1).\n* Eastern Cooperative Oncology Group performance (ECOG) 0-1.\n* Adequate organ function as defined in the protocol.\n\nExclusion Criteria:\n\n* Participants with primary central nervous system (CNS) tumors.\n* Impaired cardiac function or clinically significant cardiac disease.\n* Major surgery within 28 days of trial day 1.\n* Antitumor therapy (chemotherapy, antibody therapy, molecular targeted therapy, hormonal therapy, or investigational agent) within 21 days of first dose of trial treatment, unless anti-tumor therapy is a therapy with 5 times the half-life being shorter than 21 days (in this case, enrollment may be allowed with washout from prior therapy of \\\u003C 21 days.\n* Radiation therapy within 28 days of the first dose of trial treatment (or local or focal radiotherapy with palliative intent within 14 days of the first dose).\n* Gastrointestinal tract disease causing the inability to take per os (PO) medication, malabsorption syndrome, requirement for intravenous (IV) alimentation, uncontrolled inflammatory gastrointestinal disease (eg, Crohn's disease, ulcerative colitis).","ALL","18 Years","99 Years",{"count":259,"type":260},464,"ESTIMATED","INTERVENTIONAL",[263],"PHASE1","The primary objectives of this trial are to evaluate the safety profile of AMG 436 and to determine the maximum tolerated dose (MTD) and\u002For the recommended dose for AMG 436 as monotherapy and in combination with other anti-cancer therapies in participants with MSI-H\u002FdMMR solid tumors.",[266],"Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)",[33,268,269,270],"MSI-H","dMMR","Solid Tumors","2026-07-01",{"date":273,"type":274},"2026-07-02","ACTUAL",{"date":276,"type":274},"2026-04-08",{"date":278,"type":260},"2028-06-28",{"name":5,"class":6},20]