[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625755":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":38,"responsibleParty":68,"collaborators":25,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":25,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":25,"enrollmentInfo":79,"targetDuration":25,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Pfizer","INDUSTRY",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Part 1","EXPERIMENTAL","Monotherapy Dose Escalation",[13,14],"Drug: PF-07994525","Drug: Midazolam",{"label":16,"type":10,"description":17,"interventionNames":18},"Part 2","Monotherapy Dose Expansion",[13],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","PF-07994525","Oral administration",[9,16],null,{"type":21,"name":27,"description":23,"armGroupLabels":28,"otherNames":25},"Midazolam",[9],[30],{"name":31,"affiliation":5,"role":32},"Pfizer CT.gov Call Center","STUDY_DIRECTOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},"CONTACT","1-800-718-1021","ClinicalTrials.gov_Inquiries@pfizer.com",[39,53,58,63],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":25},"Sarah Cannon Research Institute - Pharmacy","RECRUITING","Nashville","Tennessee","37203","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-86.78444,36.16589,{"lat":51,"lon":50},{"facility":54,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":55,"geoPoint":57,"contacts":25},"SCRI Oncology Partners",{"type":48,"coordinates":56},[50,51],{"lat":51,"lon":50},{"facility":59,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":60,"geoPoint":62,"contacts":25},"Tristar BMT",{"type":48,"coordinates":61},[50,51],{"lat":51,"lon":50},{"facility":64,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":65,"geoPoint":67,"contacts":25},"TriStar Centennial Medical center",{"type":48,"coordinates":66},[50,51],{"lat":51,"lon":50},{"type":69,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100625755","phase-1-an-open-label-study-to-evaluate-pf-07994525-in-participants-with-advanced-cancers-100625755",false,"NCT07426757","An Open-Label Study to Evaluate PF-07994525 in Participants With Advanced Cancers","AN OPEN-LABEL PHASE 1 STUDY TO EVALUATE PF-07994525 IN PARTICIPANTS WITH ADVANCED MALIGNANCIES","Inclusion Criteria:\n\n* Participants aged 18 years or older (or the minimum age of consent in accordance with local regulations) at the time of informed consent.\n* Prior diagnosis of MM as defined according to IMWG criteria (Rajkumar et al. 2014)\n\nMeasurable disease based on IMWG criteria as defined by at least 1 of the following:\n\n1. Serum M-protein \\>0.5 g\u002FdL by serum protein electrophoresis (SPEP)\n2. Urinary M-protein excretion \\>200 mg\u002F24 hours by urine protein electrophoresis (UPEP)\n3. Serum immunoglobulin Free Light Chain (FLC) ≥10 mg\u002FdL (≥100 mg\u002FL) AND abnormal serum immunoglobulin kappa to lambda FLC ratio (\\\u003C0.26 or \\>1.65)\n\n   * Participants must be refractory to, or intolerant to, all established therapies known to provide clinical benefit in multiple myeloma that are an appropriate therapeutic option, in the judgement of the investigator. A minimum of 3 prior lines of therapy are required.\n   * Eastern Cooperative Oncology Group (ECOG) performance status 0-1.\n\nExclusion Criteria:\n\n* Active plasma cell leukemia, Smoldering MM, Waldenströms macroglobulinemia, Amyloidosis, POEMS Syndrome.\n* Autologous stem cell transplant within 12 weeks prior to enrollment or active Graft-versus-host disease (GVHD).\n* Active or suspected cerebral\u002Fmeningeal disease related to the underlying malignancy.\n* Any active, uncontrolled bacterial, fungal, or viral infection, including (but not limited to) COVID-19, Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), known HIV or AIDS related illness, unless deemed not clinically significant by the investigator (eg, onychomycosis).","ALL","18 Years",{"count":80,"type":81},120,"ESTIMATED","INTERVENTIONAL",[84],"PHASE1","This is an open-label, dose escalation and dose expansion study evaluating the safety, tolerability, Pharmacokinetic (PK), Pharmacodynamic (PD), and antitumor activity of PF-07994525 in participants with R\u002FR MM.\n\nThe study will consist of 2 parts: Part 1 (Dose Escalation) will consist of PF-07994525 dose escalation to assess the safety, tolerability, and preliminary antitumor activity in participants with R\u002FR MM. In Part 2 (Dose expansion), PF-07994525 may be evaluated in additional participants with R\u002FR MM to further assess safety, PK, PD, and preliminary anti-tumor activity.",[87,88],"Advanced Malignancies","Advanced Cancer",[87,90,88],"Advanced Cancers","2026-05-28",{"date":93,"type":94},"2026-06-01","ACTUAL",{"date":96,"type":81},"2026-05-15",{"date":98,"type":81},"2030-07-10",{"name":5,"class":6},4]