[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552786":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":27,"locations":35,"responsibleParty":54,"collaborators":11,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":11,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":11,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":38,"whyStopped":11,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Second Affiliated Hospital of Guangzhou Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placental gp96 induced DC cell Vaccine","EXPERIMENTAL",null,[13],"Biological: DC cell Vaccine",{"label":15,"type":10,"description":11,"interventionNames":16},"Tumor-derived gp96 induced DC cell Vaccine",[13],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"BIOLOGICAL","DC cell Vaccine","Deliver DC cell vaccine into patients for anti-ancer therapy.",[9,15],[24],{"name":25,"affiliation":5,"role":26},"Zhenfeng Zhang, MD, PhD","PRINCIPAL_INVESTIGATOR",[28,32],{"name":25,"role":29,"phone":30,"phoneExt":11,"email":31},"CONTACT","0086-020-39195965","zhangzhf@gzhmu.edu.cn",{"name":33,"role":29,"phone":30,"phoneExt":11,"email":34},"Bingjia He, MD","464677938@qq.com",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"The Second Affiliated Hospital of Guangzhou Medical University","RECRUITING","Guanzhou","Guangdong","51260","China","CN",{"type":45,"coordinates":46},"Point",[47,48],113.37117,23.06828,{"lat":48,"lon":47},[51],{"name":52,"role":29,"phone":53,"phoneExt":11,"email":31},"Zhenfeng Zhang, MD,PhD","02034153532",{"type":55,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100552786","phase-1-anti-cancer-dc-cell-vaccination-to-treat-solid-tumors-100552786",false,"NCT06477614","Anti-cancer DC Cell Vaccination to Treat Solid Tumors","Anti-cancer DC Cell Vaccination to Treat Advanced Solid Tumors: Phase I Clinical Trial","Inclusion Criteria:\n\n1\\. Patients with advanced cancer; 2. Life expectancy \\>12 weeks; 3. Adequate heart, lung, liver, kidney, and blood function; 4. Available high quality vaccine for human use; 5. Informed consent explained to, understood by and signed by patient\u002Fguardian. Patient\u002Fguardian given copy of informed consent.\n\n\\-\n\nExclusion Criteria:\n\n1. Had accepted gene therapy before;\n2. Severe virus infection such as HBV, HCV, HIV, et al;\n3. Known HIV positivity;\n4. Active infectious disease related to bacteria, virus,fungi,et al;\n5. Other severe diseases that the investigators consider not appropriate;\n6. Pregnant or lactating women;\n7. Systemic steroid treatment (greater than or equal to 0.5 mg prednisone equivalent\u002Fkg\u002Fday);\n8. Other conditions that the investigators consider not appropriate.","ALL","18 Years","80 Years",{"count":67,"type":68},60,"ESTIMATED","INTERVENTIONAL",[71],"PHASE1","Placental or tumor-derived heat shock protein gp96 is collected, purified, and stored. The DC cells are isolated from the patient's blood and then cocultured with the gp96 to obtain the activated DC cell product. The manufactured DC cells are subcutaneously or intra-tumor injected into the patient. Clinical studies will be performed to test anti-cancer function of the DC vaccination for immunotherapy of cancer patients. In this phase I study, the safety, tolerance, and preliminary efficacy of the DC vaccine immunotherapy on advanced cancers will firstly be evaluated.",[74,75],"Solid Tumor, Adult","DC",[77,78,79],"Solid Tumor","DC Vaccine","gp96","2024-06-22",{"date":82,"type":83},"2024-06-27","ACTUAL",{"date":85,"type":83},"2024-06-05",{"date":87,"type":68},"2035-12-30",{"name":5,"class":6},1]