[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579237":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":27,"locations":36,"responsibleParty":52,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":19,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":19,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":79,"overallStatus":38,"whyStopped":19,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"autologous decidual-like NK cells","EXPERIMENTAL","Autologous decidual like NK cells will be isolated and induced in vitro culture from the patients' peripheral blood and perfused into their uterine.",[13],"Biological: autologous decidual-like NK cells",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"BIOLOGICAL","intrauterine infusion",[9],null,[21,25],{"name":22,"affiliation":23,"role":24},"Yali Hu","The Affiliated Drum Tower Hospital of Nanjing University","PRINCIPAL_INVESTIGATOR",{"name":26,"affiliation":23,"role":24},"Hui Zhu",[28,33],{"name":22,"role":29,"phone":30,"phoneExt":31,"email":32},"CONTACT","86-025-83106666","11201","glyyhuyali@163.com",{"name":26,"role":29,"phone":30,"phoneExt":34,"email":35},"54330","zhuhui1231@126.com",[37],{"facility":23,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Nanjing","Jiangsu","210006","China","CN",{"type":45,"coordinates":46},"Point",[47,48],118.77778,32.06167,{"lat":48,"lon":47},[51],{"name":22,"role":29,"phone":19,"phoneExt":19,"email":19},{"type":53,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR",[55],{"name":56,"class":6},"The University of Science and Technology of China","100579237","phase-1-autologous-decidual-like-natural-killer-cells-therapy-for-infertility-or-adverse-pregnancy-history-100579237",false,"NCT06821685","Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History","Clinical Study of Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History Caused by Abnormal Uterine Natural Killer Cells","Inclusion Criteria:\n\n* abnormal uterine NK cell function;\n* have one of the following medical history: unexplained recurrent spontaneous abortions (≥2 spontaneous abortions, including biochemical pregnancy), repeated implantation failure (failure of implantation of good-quality embryos in at least two IVF cycles), unexplained infertility, early-onset severe gestational hypertension or early-onset fetal growth restriction;\n* have clear fertility desires;\n* normal ovarian function or with frozen embryos;\n* edometrium thickness measured by vaginal ultrasound before ovulation or at mid-luteal phase \\>= 7mm;\n* 18kg\u002Fm\\^2 \\\u003C Body mass index \\\u003C 30kg\u002Fm\\^2;\n\nExclusion Criteria:\n\n* using progesterone receptor modulator;\n* chromosomal karyotype abnormalities in one spouse;\n* severe endometriosis, uterine fibroids affecting the shape of the uterine cavity or the size of the whole uterus more than 2 and a half months of pregnancy, uterine malformation, uterine adhesion or thin endometrium;\n* uncontrolled autoimmune diseases;\n* abnormal blood coagulation function, abnormal liver and kidney function, or other uncontrolled basic diseases (hypertension, diabetes, thyroid disease, etc.) that the researcher access which may affect the progress of the study;\n* history of pelvic malignant tumors;\n* currently participating in other clinical studies;\n* allergic to blood products.","FEMALE","22 Years","40 Years",{"count":68,"type":69},14,"ESTIMATED","INTERVENTIONAL",[72],"PHASE1","The aim of this study is preliminary exploration of the effectiveness and duration of autologous decidual-like NK cells therapy in improving uterine NK cells dysfunction.",[75,76,77,78],"Abortion, Habitual","Infertility Unexplained","Embryo Implantation","Pre-Eclampsia",[80,81,82,83],"recurrent pregnancy loss","repeated implantation failure","unexplained infertility","decidual natural killer cells","2025-11-13",{"date":86,"type":87},"2025-11-17","ACTUAL",{"date":89,"type":87},"2025-02-13",{"date":91,"type":69},"2027-12",{"name":5,"class":6},1]