[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100446599":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":34,"centralContacts":43,"locations":53,"responsibleParty":69,"collaborators":71,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":30,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":30,"enrollmentInfo":84,"targetDuration":30,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":55,"whyStopped":30,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"BM-MSCs at 20x10^6","EXPERIMENTAL","One time infusion of islets plus BM-MSCs at 20x10\\^6\u002Fpatient, n=14",[13],"Biological: Bone marrow-derived mesenchymal stem cells",{"label":15,"type":10,"description":16,"interventionNames":17},"BM-MSCs at 50x10^6","One time infusion of islets plus BM-MSCs at 50x10\\^6\u002Fpatient, n=14",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Placebo","PLACEBO_COMPARATOR","One time infusion of islets only.",[23],"Other: Placebo",[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"BIOLOGICAL","Bone marrow-derived mesenchymal stem cells","MSC transplantation",[9,15],null,{"type":6,"name":19,"description":32,"armGroupLabels":33,"otherNames":30},"Standard of Care",[19],[35,38,40],{"name":36,"affiliation":5,"role":37},"Charlton Strange, M.D","STUDY_DIRECTOR",{"name":39,"affiliation":5,"role":37},"William Lancaster, M.D",{"name":41,"affiliation":5,"role":42},"Hongjun Wang","PRINCIPAL_INVESTIGATOR",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},"Leah Benn, MPH","CONTACT","843-792-2813","bennle@musc.edu",{"name":50,"role":46,"phone":51,"phoneExt":30,"email":52},"Kelsey Cook","843 876 0420","conder@musc.edu",[54],{"facility":5,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"RECRUITING","Charleston","South Carolina","29425","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-79.93275,32.77632,{"lat":65,"lon":64},[68],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},{"type":42,"investigatorFullName":41,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Professor, Scientific Director, Center for Cellular Therapy",[72],{"name":73,"class":74},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100446599","phase-1-autologous-mesenchymal-stromal-cells-and-islet-co-transplantation-in-tp-iat-100446599",false,"NCT05095532","Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT","Autologous Mesenchymal Stromal Cells and Islet Co-transplantation to Enhance Islet Survival and Function in Chronic Pancreatitis Patients Undergo Total Pancreatectomy and Islet Autotransplantation","Inclusion Criteria:\n\n* Diagnosis of CP and scheduled for TP-IAT;\n* ≥18 years old;\n* Diabetes with HbA1c \\\u003C12%.\n\nExclusion Criteria:\n\n* Patients who are under immunosuppression;\n* Pregnant and breastfeeding women.\n* Patients who have liver damage based on ALT, AST, and total bilirubin levels (\\>3 times normal levels);","ALL","18 Years",{"count":85,"type":86},42,"ESTIMATED","INTERVENTIONAL",[89],"PHASE1","This is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT). Participants will be randomized to either bone marrow-derived mesenchymal stem cells (MSCs) or control with the standard of care. Participants will be followed for one-year post-transplant.",[92,93],"Chronic Pancreatitis","Mesenchymal Stem Cells",[95,96],"Total Pancreatectomy","TP-IAT","2026-04-13",{"date":99,"type":100},"2026-04-16","ACTUAL",{"date":102,"type":100},"2021-12-01",{"date":104,"type":86},"2027-06-30",{"name":5,"class":6},1]