[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621045":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":38,"centralContacts":42,"locations":51,"responsibleParty":68,"collaborators":30,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":30,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":30,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":100,"whyStopped":30,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"University of Connecticut","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-BC Group","ACTIVE_COMPARATOR","Low-dose BC extract",[13],"Drug: Blackcurrant (BC) extract",{"label":15,"type":10,"description":16,"interventionNames":17},"High-BC Group","High-dose BC extract",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Control Group","PLACEBO_COMPARATOR","Placebo (no BC extract)",[23],"Drug: Placebo",[25,31,34],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Blackcurrant (BC) extract","Consume three capsules per day containing 784 mg of blackcurrant (BC) extract (261.33 mg BC and 130.67 mg placebo per capsule)",[9],null,{"type":26,"name":27,"description":32,"armGroupLabels":33,"otherNames":30},"Consume three capsules containing 1,176 mg BC of extract (392 mg BC per capsule)",[15],{"type":26,"name":35,"description":36,"armGroupLabels":37,"otherNames":30},"Placebo","Consume three placebo capsules (392 mg placebo per capsule)",[19],[39],{"name":40,"affiliation":5,"role":41},"Ock Chun, PhD","PRINCIPAL_INVESTIGATOR",[43,47],{"name":40,"role":44,"phone":45,"phoneExt":30,"email":46},"CONTACT","860-486-6275","ock.chun@uconn.edu",{"name":48,"role":44,"phone":49,"phoneExt":30,"email":50},"Briana Nosal, MS","860-878-0679","briana.nosal@uconn.edu",[52],{"facility":53,"status":30,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"University of Connecticut, Department of Nutritional Sciences","Storrs","Connecticut","06269","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-72.24952,41.80843,{"lat":63,"lon":62},[66,67],{"name":40,"role":44,"phone":45,"phoneExt":30,"email":46},{"name":48,"role":44,"phone":49,"phoneExt":30,"email":50},{"type":41,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Ock Chun","Professor","100621045","phase-1-blackcurrants-modify-gut-microbiota-and-reduce-osteoporosis-risk-in-postmenopausal-females-100621045",false,"NCT07365514","Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females","Blackcurrants Mitigate Postmenopausal Bone Loss Through Gut Microbiota-Bone Axis: A Randomized Clinical Trial Coupled With a Multi-Omics Approach to Inform Precision Nutrition","Inclusion Criteria:\n\n* postmenopausal (defined as no more than 10 years since final menstrual cycle) females aged 45-70 years\n* not on hormone replacement therapy for at least one year before initiation of the study\n* maintaining normal exercise level (\\\u003C 7 hours\u002Fweek) and willing to avoid exercise for 24 hours prior to blood and stool sampling\n* willing to ingest a dietary blackcurrant supplement or placebo (up to 1,176 mg\u002Fday, three 392mg capsules)\n* willing to avoid other dietary supplements for the duration of the study\n* willing to avoid intake of foods extremely rich in anthocyanins and fermented dairy products containing viable Bifidobacteria or Lactobacilli\n* willing to have three blood draws, three stool collections, and three bone scans\n\nExclusion Criteria:\n\n* history of cardiovascular disease, osteoporosis, metabolic bone disease, cancer, diabetes mellitus, arthritis, or other chronic inflammatory diseases\n* current smokers\n* taking prescription medications known to alter bone and calcium metabolism\n* taking anabolic agents such as parathyroid hormone or growth hormone, or steroid within 3 months before the start of the study\n* taking medications that alter bleeding (such as antiplatelets or anticoagulants) or those with a bleeding disorder\n* alcohol consumption exceeding 2 drinks\u002Fday (approximately 14g of ethanol per drink) or a total of 12\u002Fweek\n* those with planned surgery during the study period or within 2 weeks of ending the intervention\n* those with sensitivities or allergies to any of the ingredients for the placebo (rice powder)\n* planning a procedure that includes iodine, barium or nuclear medicine isotopes within the study period\n* UConn students and\u002For employees who any key personnel teach or who report to any key personnel\n* study key personnel, partners of key personnel, or dependents\u002Frelatives of any key personnel",true,"FEMALE","45 Years","70 Years",{"count":83,"type":84},159,"ESTIMATED","INTERVENTIONAL",[87],"PHASE1","The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.",[90,91,92],"Postmenopausal Osteoporosis","Gut Microbiome","Menopause",[94,95,96,97,98,99],"blackcurrant","gut microbiome","osteoporosis","menopause","females","bone aging","NOT_YET_RECRUITING","2026-01-25",{"date":103,"type":104},"2026-01-27","ACTUAL",{"date":106,"type":84},"2026-02-01",{"date":108,"type":84},"2029-09",{"name":5,"class":6},1]