[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643978":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":40,"centralContacts":45,"locations":51,"responsibleParty":65,"collaborators":28,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":28,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":28,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":91,"whyStopped":28,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Cannabis","EXPERIMENTAL","Participants receive active cannabis three times daily for approximately 16 days during one crossover treatment period. During this period, participants complete sample and self-administration sessions evaluating placebo and active intranasal opioid administration.",[13,14,15],"Drug: Cannabis","Drug: Intranasal Opioid Agonist","Drug: Oral Opioid Agonist",{"label":17,"type":18,"description":19,"interventionNames":20},"Placebo Cannabis","PLACEBO_COMPARATOR","Participants receive placebo cannabis three times daily for approximately 16 days during one crossover treatment period. During this period, participants complete sample and self-administration sessions evaluating placebo and active intranasal opioid administration.",[21,14,15],"Drug: Placebo Cannabis",[23,29,32,36],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Cannabis","Cannabis is administered three times daily during the active cannabis treatment period.",[9],null,{"type":24,"name":17,"description":30,"armGroupLabels":31,"otherNames":28},"Matched placebo cannabis is administered three times daily during the placebo treatment period.",[17],{"type":24,"name":33,"description":34,"armGroupLabels":35,"otherNames":28},"Intranasal Opioid Agonist","Intranasal opioid agonists are administered during sample and self-administration sessions",[9,17],{"type":24,"name":37,"description":38,"armGroupLabels":39,"otherNames":28},"Oral Opioid Agonist","Oral opioid agonist maintenance doses are administered four times daily throughout study participation.",[9,17],[41],{"name":42,"affiliation":43,"role":44},"Shanna Babalonis, PhD","University of Kentucky, College of Medicine","PRINCIPAL_INVESTIGATOR",[46],{"name":47,"role":48,"phone":49,"phoneExt":28,"email":50},"Paul Nuzzo","CONTACT","859-323-0002","paul.nuzzo@uky.edu",[52],{"facility":53,"status":28,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":28},"University of Kentucky Center on Drug and Alcohol Research","Lexington","Kentucky","40508","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-84.47772,37.98869,{"lat":63,"lon":62},{"type":66,"investigatorFullName":42,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"SPONSOR_INVESTIGATOR","Associate Professor","100643978","phase-1-cannabis-effects-on-opioid-self-administration-100643978",false,"NCT07668635","Cannabis Effects on Opioid Self-Administration","Impact of Cannabis on Opioid Self-Administration","Inclusion Criteria:\n\n* Participants with moderate to severe opioid use disorder who experience opioid withdrawal\n* No allergies or adverse reactions to cannabis or opioids\n* Willing to stay inpatient at the UK Hospital research center for approx. 6 weeks\n\nExclusion Criteria:\n\n* Individuals seeking treatment for opioid use disorder","ALL","18 Years","55 Years",{"count":79,"type":80},30,"ESTIMATED","INTERVENTIONAL",[83],"PHASE1","The study will enroll participants with opioid use disorder and participants will reside at the University of Kentucky Hospital for this 6-week inpatient trial. During this time, double-blind doses of cannabis and opioids will be administered. The goal of the project is to determine if cannabis can alter the drive\u002Fdesire to take opioids.",[86,87],"Opioid Use Disorder","Cannabis Use",[89,90],"opioid use","cannabis","NOT_YET_RECRUITING","2026-06-19",{"date":94,"type":95},"2026-06-25","ACTUAL",{"date":97,"type":80},"2026-07-30",{"date":99,"type":80},"2031-07-30",{"name":42,"class":6},1]