[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560200":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":48,"responsibleParty":64,"collaborators":42,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":42,"enrollmentInfo":76,"targetDuration":42,"studyType":79,"phases":80,"briefSummary":83,"conditions":84,"keywords":42,"overallStatus":89,"whyStopped":42,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Nebraska","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Hyperbaric Oxygen Therapy with Dexamethasone","EXPERIMENTAL","Participants will be treated with hyperbaric oxygen (HBO) therapy within three days of acute carbon monoxide poisoning. Treatment is a minimum of three inpatient sessions. Participants will also receive 10 mg dexamethasone per day while receiving HBO therapy (minimum of two doses, maximum of five doses if participants' stay is longer than three days). After three treatment sessions, participants will discharge home, barring no other medical complications requiring further hospitalization. In addition, continued HBO therapy plus steroids will be offered if participants are still dealing with CO poisoning sequelae as determined by study outcome measures.",[13],"Drug: Dexamethasone",{"label":15,"type":16,"description":17,"interventionNames":18},"Hyperbaric Oxygen Therapy with Placebo (Saline)","PLACEBO_COMPARATOR","Participants will be treated with hyperbaric oxygen (HBO) therapy within three days of acute carbon monoxide poisoning. Treatment is a minimum of three inpatient sessions. Participants will also a saline placebo instead of dexamethasone while receiving HBO therapy. After three treatment sessions, participants will discharge home, barring no other medical complications requiring further hospitalization. In addition, continued HBO therapy plus steroids will be offered if participants are still dealing with CO poisoning sequelae as determined by study outcome measures.",[19],"Drug: saline placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","saline placebo","IV saline bolus",[15],[27],"nebulized normal saline (NS) placebo",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Dexamethasone","10mg IV Dexamethasone",[9],[33],"Ozurdex, Maxidex, DexPak 10 day, DexPak 6 Day, LoCort, DoubleDex, ReadySharp dexamethasone, DexPak 13 Day, ZonaCort",[35],{"name":36,"affiliation":5,"role":37},"Jeffrey S Cooper, MD","PRINCIPAL_INVESTIGATOR",[39,44],{"name":36,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","402-552-2490",null,"jeffrey.cooper@unmc.edu",{"name":45,"role":40,"phone":46,"phoneExt":42,"email":47},"Brooklin Zimmerman, MSN","402-559-5237","brooklin.zimmerman@unmc.edu",[49],{"facility":50,"status":42,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Nebraska Medicine, Hyperbaric Medicine Program, Clarkson Tower","Omaha","Nebraska","68105","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-95.94043,41.25626,{"lat":60,"lon":59},[63],{"name":36,"role":40,"phone":41,"phoneExt":42,"email":43},{"type":65,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100560200","phase-1-carbon-monoxide-hyperbaric-oxygen-with-steroid-therapy-100560200",false,"NCT06574048","Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy","Trial of Dexamethasone vs Placebo as an Adjunctive Therapy to Hyperbaric Oxygen Treatment HBO in Patients With Acute Carbon Monoxide Poisoning","CODex","Inclusion Criteria:\n\n* Acute CO poisoning, intentional or non-intentional exposure, receiving HBO treatment during hospitalization\n* Age \\>18 years\n* Nebraska Medicine admission\n\nExclusion Criteria:\n\n* Mechanical ventilation\n* No hospital admission or admission to hospital Critical Care Medicine Service\n* Allergy to dexamethasone\n* Pre-Existing neurological condition confounding outcome determination","ALL","19 Years",{"count":77,"type":78},20,"ESTIMATED","INTERVENTIONAL",[81,82],"PHASE1","PHASE2","Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if neurologic outcomes are improved with the addition of dexamethasone. CO poisoning can initiate a free radical mediated process that can instigate a demyelinating process resulting in long term neurological sequelae in some, but not all patients. In other demyelinating disorders, steroids are a part of first line treatment. HBO is already used for acute CO poisoning, so this pilot study will try to ascertain if the addition of steroids in concert with each hyperbaric oxygen session will yield improved outcomes.",[85,86,87,88],"Carbon Monoxide Poisoning","Carbon Monoxide Intoxication","Carbon Monoxide Encephalopathy","Carbon Monoxide-induced Parkinsonism","NOT_YET_RECRUITING","2026-04-13",{"date":92,"type":93},"2026-04-17","ACTUAL",{"date":95,"type":78},"2026-07",{"date":97,"type":78},"2028-01",{"name":5,"class":6},1]