[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614939":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":36,"locations":46,"responsibleParty":63,"collaborators":27,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":27,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":27,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":27,"overallStatus":86,"whyStopped":27,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Fudan University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Integrated Traditional Chinese and Conventional Medical Treatment Group","EXPERIMENTAL","Conventional Medical Treatment:\n\nFor ischemic-type moyamoya disease, antiplatelet monotherapy with cilostazol is administered, while antiplatelet therapy is not recommended for asymptomatic patients or those with hemorrhagic-type moyamoya disease. For patients with concomitant dyslipidemia, statins and evolocumab may be added, with low-density lipoprotein cholesterol controlled to 70 mg\u002FdL (1.8 mmol\u002FL). Blood pressure is maintained at 140\u002F90 mmHg, and glycemic management targets a hemoglobin A1c level of \\\u003C7.0%.\n\nTraditional Chinese Medicine (TCM) Treatment:\n\nPatients receive the standardized TCM formula Qiqi Shengmai Decoction (composed of Astragali Radix, Rehmanniae Radix Praeparata, Schisandrae Fructus, Bupleuri Radix, Paeoniae Radix Alba, and Notoginseng Radix). The prescription is taken twice daily, one dose per administration, for six consecutive weeks, with each dose consumed 30 minutes after breakfast and dinner",[13,14],"Drug: Traditional Chinese Medicine (TCM) Treatment","Drug: Conventional medical treatment",{"label":16,"type":17,"description":18,"interventionNames":19},"Conventional Medical -Only Treatment Group","PLACEBO_COMPARATOR","Conventional Medical Treatment： For ischemic-type moyamoya disease, antiplatelet monotherapy with cilostazol is administered, whereas antiplatelet therapy is not recommended for asymptomatic patients or those with hemorrhagic-type moyamoya disease. For patients with concomitant dyslipidemia, statins and evolocumab may be added, with low-density lipoprotein cholesterol controlled to 70 mg\u002FdL (1.8 mmol\u002FL). Blood pressure is maintained at 140\u002F90 mmHg, and glycemic management targets a hemoglobin A1c level of \\\u003C7.0%.\n\nTCM Placebo:\n\nThe placebo consists primarily of medicinal starch, food-grade caramel coloring (for color correction), and a bittering agent (for flavor adjustment). Its appearance-including shape, size, color, and taste-is identical to that of the herbal preparation. It is administered twice daily, one dose at each administration, for six consecutive weeks, taken 30 minutes after breakfast and dinner.",[14,20],"Drug: TCM Placebo",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","Traditional Chinese Medicine (TCM) Treatment","Patients receive the standardized TCM formula Qiqi Shengmai Decoction (composed of Astragali Radix, Rehmanniae Radix Praeparata, Schisandrae Fructus, Bupleuri Radix, Paeoniae Radix Alba, and Notoginseng Radix). The prescription is taken twice daily, one dose per administration, for six consecutive weeks, with each dose consumed 30 minutes after breakfast and dinner",[9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Conventional medical treatment","For ischemic-type moyamoya disease, antiplatelet monotherapy with cilostazol is administered, while antiplatelet therapy is not recommended for asymptomatic patients or those with hemorrhagic-type moyamoya disease. For patients with concomitant dyslipidemia, statins and evolocumab may be added, with low-density lipoprotein cholesterol controlled to 70 mg\u002FdL (1.8 mmol\u002FL). Blood pressure is maintained at 140\u002F90 mmHg, and glycemic management targets a hemoglobin A1c level of \\\u003C7.0%.",[16,9],{"type":23,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"TCM Placebo","The placebo consists primarily of medicinal starch, food-grade caramel coloring (for color correction), and a bittering agent (for flavor adjustment). Its appearance-including shape, size, color, and taste-is identical to that of the herbal preparation. It is administered twice daily, one dose at each administration, for six consecutive weeks, taken 30 minutes after breakfast and dinner.",[16],[37,42],{"name":38,"role":39,"phone":40,"phoneExt":27,"email":41},"Ziyang He, MD","CONTACT","+86 180 5073 1566","heziyang0207@gmail.com",{"name":43,"role":39,"phone":44,"phoneExt":27,"email":45},"Zhigang Yang, MD","+86 137 6122 1410","yang.zhigang1@zs-hospital.sh.cn",[47],{"facility":48,"status":27,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"180 Fenglin Road, Xuhui District, Shanghai 200032,China","Shanghai","Shanghai Municipality","200032","China","CN",{"type":55,"coordinates":56},"Point",[57,58],121.45806,31.22222,{"lat":58,"lon":57},[61],{"name":62,"role":39,"phone":40,"phoneExt":27,"email":41},"Ziyang He",{"type":64,"investigatorFullName":62,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Sub-Investigator","100614939","phase-1-chinese-herbal-therapy-qiqi-shengmai-formula-for-moyamoya-vasculopathy-the-chimes-trial-100614939",false,"NCT07286110","Chinese Herbal Therapy (Qiqi Shengmai Formula) for Moyamoya Vasculopathy: The CHIMES Trial","Effect of Chinese Herbal Intervention (Qiqi Shengmai Formula) for Moyamoya Vasculopathy in Cerebral Hemodynamics (CHIMES ): a Single-center, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n1. Imaging findings meeting the Western medical diagnostic criteria for moyamoya vasculopathy\n2. Age between 18 and 80 years\n3. The patient and family members are fully informed and voluntarily consent to participation, with the informed consent process conducted in accordance with GCP requirements\n4. Willingness to receive Traditional Chinese Medicine treatment\n5. Traditional Chinese Medicine syndrome differentiation consistent with liver-yang hyperactivity\n\nExclusion Criteria:\n\n1. Acute cerebrovascular events within the preceding 6 weeks\n2. Known allergy to contrast agents or to the investigational medication\n3. Presence of severe primary diseases involving the cardiac, pulmonary, hepatic, renal, endocrine, or hematopoietic systems\n4. Pregnant or breastfeeding women\n5. Patients scheduled to undergo cerebral revascularization surgery\n6. Participation in other ongoing clinical trial","ALL","18 Years","80 Years",{"count":77,"type":78},66,"ESTIMATED","INTERVENTIONAL",[81],"PHASE1","Patients diagnosed with moyamoya vasculopathy by imaging and classified as having the Traditional Chinese Medicine (TCM) syndrome of liver-yang hyperactivity will be enrolled. On the basis of standardized Western medical management, participants will receive the standardized TCM herbal formula \"Qiqi Shengmai Formula\" (comprising Astragali Radix, Rehmanniae Radix Praeparata, Schisandrae Fructus, Bupleuri Radix, Paeoniae Radix Alba, and Notoginseng Radix). Structured follow-up will be conducted. By comparing endpoint indicators across different treatment regimens, the study aims to evaluate the efficacy of integrated TCM-Western medicine therapy for moyamoya vasculopathy and to generate evidence-based support for an integrated diagnostic and therapeutic model.",[84,85],"Moyamoya Disease","Moyamoya Syndrome","NOT_YET_RECRUITING","2025-12-16",{"date":89,"type":90},"2025-12-22","ACTUAL",{"date":92,"type":78},"2025-12-30",{"date":94,"type":78},"2026-12-30",{"name":5,"class":6},1]