[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605377":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":54,"collaborators":57,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":26,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":42,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"(-)-Epicatechin combined with exercise","ACTIVE_COMPARATOR","12 weeks of daily cocoa (2 capsules\u002Fd containing 450 mg cocoa flavanols\u002Fd, including 80 mg of (-)-epicatechin) combined with aerobic (30min of moderate-intensity walking) and resistance (25 min of whole-body workout) exercise training 3 times a week",[13],"Combination Product: (-)-Epicatechin-rich cocoa supplementation combined with exercise training",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo combined with exercise","PLACEBO_COMPARATOR","12 weeks of placebo (alike-looking cellulose-based capsules) combined with aerobic (30min of moderate-intensity walking) and resistance (25 min of whole-body workout) exercise training 3 times a week",[19],"Combination Product: Placebo combined with exercise training",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","(-)-Epicatechin-rich cocoa supplementation combined with exercise training","12 weeks of daily cocoa (2 capsules\u002Fd containing 450 mg cocoa flavanols\u002Fd, including 80 mg of (-)-epicatechin) combined with aerobic (30min of moderate-intensity walking) and resistance (30 min of whole-body workout) exercise training 3 times a week",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo combined with exercise training","12 weeks of placebo (alike-looking cellulose-based capsules) combined with aerobic (30min of moderate-intensity walking) and resistance (30 min of whole-body workout) exercise training 3 times a week",[15],[32],{"name":33,"affiliation":5,"role":34},"Robert T Mankowski, PhD","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","205-996-3006","rmankowski@uabmc.edu",[41],{"facility":5,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":26},"RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-86.80249,33.52066,{"lat":52,"lon":51},{"type":34,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Robert T Mankowski","Associate Professor",[58,61],{"name":59,"class":60},"National Institutes of Health (NIH)","NIH",{"name":62,"class":60},"National Institute on Aging (NIA)","100605377","phase-1-cocoa-to-maximize-exercise-training-in-older-adults---the-comet-trial-100605377",false,"NCT07161726","Cocoa to Maximize Exercise Training in Older Adults - The COMET Trial","COMET","Inclusion Criteria:\n\n* Age 55 years and older\n* Slow walking speed of \\\u003C 1m\u002Fs\n* Willingness to be randomized to either treatment group\n* Willingness to participate in all study procedures (muscle biopsy will be optional)\n\nExclusion Criteria:\n\n* Failure to provide informed consent;\n* Regular consumption of flavanol and\u002For cocoa supplements\n* Current involvement in supervised rehabilitation\u002Fexercise training program\n* Absolute contraindication(s) to exercise training according to American College of Sports Medicine guidelines \\[17\\]\n* Daytime average of systolic blood pressure ≥ 180\u002F100mm Hg.\n* Refusal to stop blood thinners such as baby aspirin dose.\n* Peripheral vascular disease; peripheral neuropathy; retinopathy\n* Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina;\n* Myocardial infarction or stroke within past year\n* Significant cognitive impairment, including known dementia diagnosis or a Mini-Mental State Examination exam score \\\u003C 24\n* Progressive, degenerative neurologic disease, e.g., Parkinson's Disease, multiple sclerosis;\n* Severe rheumatologic or orthopedic diseases, e.g., awaiting joint replacement, active inflammatory disease;\n* Severe pulmonary disease, requiring either steroid pills or injections or the use of supplemental oxygen;\n* Hip fracture, hip or knee replacement, or spinal surgery within past 4 months;\n* Other significant co-morbid conditions that would impair ability to participate in the exercise-based intervention\n* Simultaneous participation in another interventional trial","ALL","55 Years",{"count":73,"type":74},36,"ESTIMATED","INTERVENTIONAL",[77,78],"PHASE1","PHASE2","The purpose of the study is to see if regular exercise when combined with a cocoa supplement will improve physical performance and muscle strength compared to regular exercise alone.",[81],"Mobility Disability",[83,84,85,86],"Cocoa","Exercise","Mobility","Older adults","2026-05-07",{"date":89,"type":90},"2026-05-08","ACTUAL",{"date":92,"type":90},"2026-04-21",{"date":94,"type":74},"2027-12-31",{"name":5,"class":6},1]