[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100516478":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":38,"responsibleParty":57,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":25,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":25,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Stanford University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"pSOPT","EXPERIMENTAL","personalized cognitive training with a close-loop parasympathetic nervous system monitored component",[13],"Behavioral: pSOPT",{"label":15,"type":16,"description":17,"interventionNames":18},"MLA","PLACEBO_COMPARATOR","computerized mental leisure activities",[19],"Behavioral: MLA",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","computerized cognitive training practicing speed of processing, the difficulty will be adjusted based on real-time monitored RMSSD (parasympathetic nervous system signals)",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"computerized mental leisure activities on cross-word puzzle, Sudoku, and solitaire; ECG will also be applied.",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Feng Lin, BS","CONTACT","6082156005","cogtlab_stanford@stanford.edu",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":34},"Sarah Therrien","(650) 497-8434",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"CogT Lab, Stanford University","RECRUITING","Palo Alto","California","94304-0000","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-122.14302,37.44188,{"lat":51,"lon":50},[54],{"name":36,"role":32,"phone":55,"phoneExt":25,"email":56},"650-497-8434","stherrie@stanford.edu",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Feng Lin","Clinical Professor","100516478","phase-1-cogt-psopt-intervention-study-100516478",false,"NCT06005038","CogT pSOPT Intervention Study","Personalized Engine for Speed of Information Processing","Inclusion Criteria:\n\n1. criteria related to defining \"mild cognitive impairment\": a. Presence of memory complaint; b. Rey Auditory Verbal Learning Test delayed recall (for memory) \\\u003C 59% of age-adjusted norm; c. Montreal Cognitive Assessment (for global cognition) ranged 18 and 27; d. Functional Assessment Questionnaire (for activities of daily living) \\\u003C 20.\n2. intact score for San Diego Brief Assessment of Capacity to Consent (UBACC).\n3. if a participant is on AD medication (i.e., memantine, cholinesterase inhibitors, amyloid antibodies), antidepressants, anxiolytics, or vascular risk or diseases related medications (e.g., beta-blocker), the dose should be stable for 3 months prior to recruitment.\n4. age 60+,\n5. read and understand English\n6. adequate visual and hearing acuity for testing by self-report,\n7. community-dwelling (including independent living).\n\nExclusion Criteria:\n\n1. current enrollment in another cognitive improvement study;\n2. uncontrollable major depression;\n3. major cerebrovascular and cardiovascular diseases (e.g., congestive heart failure, pacemaker, prior myocardial infarction);\n4. having an active legal guardian (indicating impaired capacity for decision making);\n5. currently pregnant\n6. 3T MRI contraindication\n7. Neurological conditions: Neurodegenerative disease diagnosis such as Parkinson's, Alzheimers, dementia, multiple sclerosis. Of note, other neurological conditions\u002Finjury such as stroke, seizures, traumatic brain injury, will be evaluated for inclusion\u002Fexclusion on a case-by-case basis based on event recency, severity, and recovery.",true,"ALL","60 Years",{"count":72,"type":73},50,"ESTIMATED","INTERVENTIONAL",[76],"PHASE1","(JUSTIFICATION: This is the R33 stage of an NIH funded R21\u002FR33 study. R21 stage (IRB-61727) was focused on intervention development; R33 stage will focus on pilot testing the effect of the intervention. The R21 phase was not considered a NIH defined clinical trial; R33 will be considered a NIH defined clinical trial)\n\nThe purpose is to develop and test the effect of a \"personalized\" computer-based cognitive training program. The personalized program tailors the difficulty of the training tasks using a participant's biofeedback (i.e., heart rate) and cognitive performance. Such a personalization will ensure that the participant can perform at his\u002Fher ideal training capacity. Participants will be randomized into one of 2 groups and each group will play a different version of computerized training game and have ECG collected to allow subject blinding.",[79,80],"Mild Cognitive Impairment","Subjective Cognitive Impairment","2024-05-16",{"date":83,"type":84},"2024-05-17","ACTUAL",{"date":86,"type":84},"2024-01-12",{"date":88,"type":73},"2026-12-31",{"name":5,"class":6},1]