[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625962":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":38,"responsibleParty":58,"collaborators":62,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Services Institute of Medical Sciences, Pakistan","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A participants who will receive Bupivacaine Intraperitoneally","EXPERIMENTAL","This group consists of 30 participants and will receive Bupivacaine with 0.25% of concentration intraperitoneally during open appendectomy. Surgery duration will be noted. Analgesic consumption will also be recorded at 2, 6, 12 and 24 hours postoperatively. 1st Rescue analgesia will be given in the form of injection Ketorolac at a dose of 0.5mg\u002Fkg whenever the patient reported visual analogue score greater and equal to 4. However, if 1st rescue analgesia fails injection Nalbuphine with dose of 0.1mg\u002Fkg per dose will be used as 2nd rescue analgesia. Injection paracetamol 1g IV TDS will be given to all patients considered to be sufficient 1st line analgesia. Patients will be discharged 2 days after surgery when diet and pain will be tolerated. If pain persisted at the time of discharge, oral analgesics will be given for 3 or 4 days. Post operative follow up will be done according to protocol. All information will be recorded on a preformed proforma.",[13],"Drug: Bupivacain",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B participants who will receive 10 ml of normal saline Intraperitoneally","ACTIVE_COMPARATOR","This group consists of 30 participants and will receive 10 ml of Normal Saline intraperitoneally during open appendectomy. Surgery duration will be noted. Analgesic consumption will also be recorded at 2, 6, 12 and 24 hours postoperatively. 1st Rescue analgesia will be given in the form of injection Ketorolac at a dose of 0.5mg\u002Fkg whenever the patient reported visual analogue score greater and equal to 4. However, if 1st rescue analgesia fails injection Nalbuphine with dose of 0.1mg\u002Fkg per dose will be used as 2nd rescue analgesia. Injection paracetamol 1g IV TDS will be given to all patients considered to be sufficient 1st line analgesia. Patients will be discharged 2 days after surgery when diet and pain will be tolerated. If pain persisted at the time of discharge, oral analgesics will be given for 3 or 4 days. Post operative follow up will be done according to protocol. All information will be recorded on a preformed proforma.",[19],"Other: Normal Saline",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Bupivacain","Bupivacaine with 0.25% of concentration at the end of the operation intraperitoneally.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"OTHER","Normal Saline","10ml of Normal Saline at the end of the operation intraperitoneally.",[15],[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Dr Sardar Umar Rehman, MBBS","CONTACT","+923319326657","umersardar578@gmail.com",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Services Institute of Medical Sciences\u002F Services Hospital Lahore","RECRUITING","Lahore","Punjab Province","54000","Pakistan","PK",{"type":48,"coordinates":49},"Point",[50,51],74.35071,31.558,{"lat":51,"lon":50},[54],{"name":55,"role":35,"phone":56,"phoneExt":26,"email":57},"Prof Javaid Ur Rehman Ashraf, MBBS, FCPS","+923334233682","javaid.rehman@yahoo.com",{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Sardar Umer Rehman","Principal Investigator",[63],{"name":5,"class":6},"100625962","phase-1-comparison-of-clinical-outcomes-of-intraperitoneal-bupivacaine-instillation-versus-placebo-as-preemptive-analgesia-in-patients-undergoing-open-appendectomy-100625962",false,"NCT07429448","Comparison Of Clinical Outcomes of Intraperitoneal Bupivacaine Instillation Versus Placebo as Preemptive Analgesia in Patients Undergoing Open Appendectomy","Inclusion Criteria:\n\n* Patients presenting to the emergency department undergoing open appendectomy.\n\nExclusion Criteria:\n\n* Patients undergoing interval appendectomy or having perforated appendix as evident by examination (abdominal tenderness\u002F fever) and USG findings (presence of abscess, fluid collection, or free air).\n* Uncontrolled medical disease (DM: BSL \\>200mg\u002Fdl, HTN: BP \\>140\u002F90)\n* History of chronic kidney or liver disease\u002F psychiatric illness\u002F Active peptic ulcer disease (as determined on history and medical records)\n* Alcoholics\n* History of chronic pain or patients on analgesic medications\n* Pregnant females\n* History of allergy to bupivacaine\u002F ketorolac as determined on history\n* Children, Adolescents and patients with mental illness.","ALL","20 Years","60 Years",{"count":74,"type":75},60,"ESTIMATED","INTERVENTIONAL",[78],"PHASE1","To compare the clinical outcomes of intraperitoneal bupivacaine instillation vs placebo as preemptive analgesia in patients undergoing open appendectomy",[81],"Appendectomy",[83,84,85],"Analgesia","Bupivacaine","Open Appendectomy","2026-02-17",{"date":88,"type":89},"2026-02-24","ACTUAL",{"date":91,"type":89},"2025-12-16",{"date":93,"type":75},"2026-06-16",{"name":60,"class":6},1]