[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567440":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":28,"locations":11,"responsibleParty":34,"collaborators":11,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":11,"eligibilityCriteria":44,"healthyVolunteers":40,"sex":45,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":11,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":59,"whyStopped":11,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":11},{"fullName":5,"class":6},"Assiut University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: 25 patients will receive caudal block with 1 ml\u002Fkg bupivacaine 0.25% and dexmedetomidine 0.","ACTIVE_COMPARATOR",null,[13,14],"Drug: Dexmedetomidine","Drug: Bupivacain",{"label":16,"type":10,"description":11,"interventionNames":17},"Group B: 25 patients will receive caudal block with 1 ml\u002Fkg bupivacaine 0.25% and dexmedetomidine 1",[13,14],[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","Dexmedetomidine","Dexmedetomidine has become more popular as a caudal adjuvant in children; it is a highly selective α2 agonist with sedative and analgesic properties. Dexmedetomidine possesses anxiolytic, sedative, sympatholytic, and analgesic properties without respiratory depressant effects In addition; dexmedetomidine has the ability to reduce both the anesthetic and opioid analgesic requirements during the perioperative period.",[9,16],{"type":20,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Bupivacain","Bupivacaine is a potent local anesthetic with unique characteristics from the amide group of local anesthetics.",[9,16],[29],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"ahmed gamal mahmoud","CONTACT","+201129915169","ahmed.15235520@med.aun.edu.eg",{"type":35,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Ahmed Gamal Mahmoud Hamed","Resident","100567440","phase-1-effect-of-adding-different-concentrations-of-dexmedetomidine-to-bupivacaine-in-caudal-block-for-pediatrics-100567440",false,"NCT06668220","Effect of Adding Different Concentrations of Dexmedetomidine to Bupivacaine in Caudal Block for Pediatrics","Effect of Adding Different Concentrations of Dexmedetomidine to Bupivacaine in Caudal Block for Pediatrics Undergoing Inguinal Hernia Repair","Inclusion Criteria:\n\n* ASA I and II,\n* aged 1-6 years\n* scheduled for elective inguinal hernia repair\n\nExclusion Criteria:\n\n* Guardians refusal\n* Contraindication to caudal block like :\n\n  * Patients with congenital anomalies at the lower spine or meninges\n  * Patients with increased intracranial pressure\n  * Patients with skin infection at the site of injection\n  * Patients with bleeding diathesis\n  * Know allergy to any drug used in this study\n* Patients with cardiopulmonary disease\n* Patients with other congenital anomalies\n* Patients with developmental delay","MALE","1 Year","6 Years",{"count":49,"type":50},50,"ESTIMATED","INTERVENTIONAL",[53],"PHASE1","Pain is one of the medical problems frequently misdiagnosed, undertreated, and poorly under-stood, particularly in children.Poor pain management during childhood may have long-term deleterious impacts, including damaging neuro-endocrine reactions, disturbed eating and sleeping pat-terns, and increased pain sensitivity during subsequent painful events.\n\nA caudal epidural block is a common regional analgesic technique in pediatric surgery . It is a time-tested, safe, and efficacious technique However, the duration of post-operative pain seen with much pediatric surgery (\\>24 h) outlasts the duration of analgesia afforded by a standard 'local-anesthetics only' caudal block (4-12 h) While continuous catheters prolong analgesic duration, such techniques are more cumbersome, require significant technical expertise and may be associated with higher adverse events. Contrary to this, adding adjuvants to local anesthetic is an appealing alternative. Adjuvants can improve the block and analgesic duration , reduce general anesthetic or local anesthetic requirements, allow for smoother emergence, lower incidence of emergence delirium, and facilitate early discharge in ambulatory surgery.\n\nVarious adjuvants have been shown to enhance caudal blocks with varying degrees of success. A multitude of clinical trials and meta-analyses have analyzed the efficacy of different adjuvants such as alpha-2 agonists (clonidine and dexmedetomidine ), N-methyl-D-aspartate (NMDA) antagonists (ketamine and magnesium ), opioids (fentanyl, morphine, and tramadol ), corticosteroids (dexamethasone ), and acetylcholine esterase inhibitors (neostigmine).\n\nDexmedetomidine has become more popular as a caudal adjuvant in children; it is a highly selective α2 agonist with sedative and analgesic properties. Dexmedetomidine possesses anxiolytic, sedative, sympatholytic, and analgesic properties without respiratory depressant effects In addition; dexmedetomidine has the ability to reduce both the anesthetic and opioid analgesic requirements during the perioperative period.",[56],"Caudal Block for Postoperative Analgesia",[58],"caudal block","NOT_YET_RECRUITING","2024-11-11",{"date":62,"type":63},"2024-11-13","ACTUAL",{"date":65,"type":50},"2024-11-20",{"date":67,"type":50},"2026-10-30",{"name":5,"class":6}]