[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595062":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":46,"centralContacts":51,"locations":61,"responsibleParty":83,"collaborators":55,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":55,"eligibilityCriteria":92,"healthyVolunteers":88,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":55,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":108,"whyStopped":55,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Universidade Federal do Para","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo group","PLACEBO_COMPARATOR","The placebo gel (PG) (natrosol 4%) will be applied to the buccal surfaces of the central and lateral incisors, canines and upper and lower premolars, with a microbrush actively, for 10 minutes. Subsequently, all groups will undergo in-office whitening treatment with 35% hydrogen peroxide (Whiteness HP, FGM). Sensitivity assessment will be carried out using a form consisting of a visual analogue scale (VAS), patients will be instructed to record tooth sensitivity daily, during the 21 days of follow-up. To measure color, the VITA Easyshade spectrophotometer (VITA, Germany)) will be used at two times: baseline (Ti) and one week after the 3rd bleaching session (Tf).",[13],"Drug: Natrosol 4% Gel",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","ACTIVE_COMPARATOR","gel with 5% potassium nitrate and 2% sodium fluoride The gel with 5% potassium nitrate and 2% sodium fluoride (NKFG) will be applied to the buccal surfaces of the central and lateral incisors, canines and upper and lower premolars, with a microbrush actively, for 10 minutes. Subsequently, all groups will undergo in-office whitening treatment with 35% hydrogen peroxide (Whiteness HP, FGM). Sensitivity assessment will be carried out using a form consisting of a visual analogue scale (VAS), patients will be instructed to record tooth sensitivity daily, during the 21 days of follow-up. To measure color, the VITA Easyshade spectrophotometer (VITA, Germany) will be used at two",[19],"Drug: Potassium nitrate and sodium fluoride",{"label":21,"type":22,"description":23,"interventionNames":24},"Experimental group","EXPERIMENTAL","The experimental 2% cannabidiol gel (GCBD) will be applied to the buccal surfaces of the central and lateral incisors, canines and upper and lower premolars, with an active microbrush, for 10 minutes. Subsequently, all groups will undergo in-office whitening treatment with 35% hydrogen peroxide (Whiteness HP, FGM). Sensitivity assessment will be carried out using a form consisting of a visual analogue scale (VAS), patients will be instructed to record tooth sensitivity daily, during the 21 days of followup. To measure color, the VITA Easyshade spectrophotometer (VITA, Germany) will be used at two times: baseline (Ti) and one week after the 3rd bleaching session (Tf).",[25],"Drug: Cannabidiol (CBD) Gel",[27,34,40],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","Potassium nitrate and sodium fluoride","Gel with 5% potassium nitrate and 2% sodium fluoride gel of 5% potassium nitrate and 2% sodium fluoride for topical application to teeth before bleaching with hydrogen peroxide",[15],[33],"GC",{"type":28,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Cannabidiol (CBD) Gel","Cannabidiol gel for teeth ( 2% cannabidiol oil) before bleaching with hydrogen peroxide",[21],[39],"GCBD",{"type":28,"name":41,"description":42,"armGroupLabels":43,"otherNames":44},"Natrosol 4% Gel","placebo gel (natrosol-based gel 4%) for topical application to teeth before bleaching with hydrogen peroxide.",[9],[45],"GP",[47],{"name":48,"affiliation":49,"role":50},"Jesuína L Nogueira Araújo, PHD","Federal University of Pará","PRINCIPAL_INVESTIGATOR",[52,57],{"name":48,"role":53,"phone":54,"phoneExt":55,"email":56},"CONTACT","5591991442849",null,"jesuinalamartine@hotmail.com",{"name":58,"role":53,"phone":59,"phoneExt":55,"email":60},"Marina L Wanderley, Msc","5591992240588","marina_lw@hotmail.com",[62],{"facility":63,"status":55,"city":64,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"Federal University of Pará School of Dentistry","Belém","Pará","66075-110","Brazil","BR",{"type":70,"coordinates":71},"Point",[72,73],-48.50444,-1.45583,{"lat":73,"lon":72},[76,80],{"name":77,"role":53,"phone":78,"phoneExt":55,"email":79},"Sandro C Loretto, PHD","55 91 8122-3477","sandroloretto@hotmail.com",{"name":81,"role":82,"phone":55,"phoneExt":55,"email":55},"Cecy M Silva, PHD","SUB_INVESTIGATOR",{"type":50,"investigatorFullName":84,"investigatorTitle":85,"investigatorAffiliation":5,"oldNameTitle":55,"oldOrganization":55},"Jesuína Lamartine Nogueira Araújo","Principal Investigator: Clinical Professor","100595062","phase-1-effect-of-an-experimental-cannabidiol-gel-on-tooth-sensitivity-100595062",false,"NCT07027566","Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity","Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity Induced by Tooth Bleaching","Inclusion Criteria:\n\n* Participants must have at least 28 teeth in the cavity\n* Good oral and general health\n\nExclusion Criteria:\n\n* active caries or periodontal disease\n* visible cracks in front teeth upper or lower\n* with evident malocclusion\n* restorations and prosthetics in teeth anterior teeth\n* gastroesophageal disorders\n* severe internal tooth discoloration (tetracycline , fluorosis or pulped teeth)\n* dentin exposure in anterior teeth and \u002For later\n* parafunctional habits\n* tooth sensitivity\n* whitening treatment prior to or undergoing orthodontic treatment\n* Furthermore, smokers, pregnant or breastfeeding women do not will be included.","ALL","18 Years","40 Years",{"count":97,"type":98},75,"ESTIMATED","INTERVENTIONAL",[101],"PHASE1","The goal of this clinical trial will be to evaluate the effect applying an experimental gel based on cannabidiol oil (CBD) on tooth sensitivity induced by tooth bleaching with 35% hydrogen peroxide (HP). Volunteers will be selected and allocated to the following groups: GP - placebo gel, GCBD - experimental cannabidiol gel and GKF - Potassium Nitrate and Sodium Fluoride Gel. In each group, the corresponding desensitizing gel will be applied to on the teeth for 10 minutes. All groups will then undergo in-office whitening treatment with 35% hydrogen peroxide. Patients will be instructed to record tooth sensitivity on a daily basis during the 21 days of follow-up. Pain intensity will be measured using a visual analog scale (VAS), while the risk of developing sensitivity will be recorded after each session of the whitening procedure, with two response option.",[104],"Dentin Sensitivity",[106,107,104],"Tooth Bleaching","Cannabidiol","NOT_YET_RECRUITING","2025-06-10",{"date":111,"type":112},"2025-06-18","ACTUAL",{"date":114,"type":98},"2025-07-25",{"date":116,"type":98},"2026-07",{"name":5,"class":6},1]