[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570818":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":50,"responsibleParty":63,"collaborators":44,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":44,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":44,"enrollmentInfo":75,"targetDuration":44,"studyType":78,"phases":79,"briefSummary":82,"conditions":83,"keywords":89,"overallStatus":52,"whyStopped":44,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Liaquat National Hospital & Medical College","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention group\u002FGroup D","EXPERIMENTAL","Intervention group: Group D patients will be administer 0.5 mcg\u002Fkg dexmedetomidine intravenously over 10 min preoperatively.",[13],"Drug: Dexmedetomidine Group \u002F Group D",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group\u002FGroup C","PLACEBO_COMPARATOR","Control group: Group C patients will be administer the same volume of normal saline (also intravenously for 10 min)",[19],"Other: Normal Saline (Placebo)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Dexmedetomidine Group \u002F Group D","In this study, the intervention involve administrating 0.5 mcg\u002Fkg of Inj dexmedetomidine intravenously over 10 min to patients in intervention group\u002Fgroup D 2 minutes prior to Endotracheal intubation using laryngoscopy aiming to asses its efficacy in attenuating the pressor response to laryngoscopy.",[9],[27],"Dexemeditomidine",{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Normal Saline (Placebo)","The Placebo group \u002F group C will be administer Normal Saline without any active medication over 10 min to patients, 2 minutes prior to Endotracheal intubation using laryngoscopy to compare its effect to those of Dexmedetomidine in attenuating the pressor response to laryngoscopy.",[15],[33],"normal saline",[35],{"name":36,"affiliation":37,"role":38},"Warisha ismail Dr Warisha ismail","Liaquat National Hospital and Medical College","PRINCIPAL_INVESTIGATOR",[40,46],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Warisha Ismail Dr Warisha Ismail","CONTACT","+92 3046878028",null,"khanveera97@gmail.com",{"name":47,"role":42,"phone":48,"phoneExt":44,"email":49},"Ghulam fatima Ghulam Fatima","+92336873293","drghulamfatimakhar@gmail.com",[51],{"facility":37,"status":52,"city":53,"state":54,"zip":44,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":44},"RECRUITING","Karachi","Sindh","Pakistan","PK",{"type":58,"coordinates":59},"Point",[60,61],67.0104,24.8608,{"lat":61,"lon":60},{"type":38,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"Warisha Ismail","Warisha Ismail Dr, FCPS I","100570818","phase-1-effect-of-dexmedetomidine-on-hemodynamic-response-to-endotracheal-intubation-in-hypertensive-patients-100570818",false,"NCT06712186","Effect of Dexmedetomidine on Hemodynamic Response to Endotracheal Intubation in Hypertensive Patients","Title: the Effects of Dexmedetomidine on Hemodynamic Responses to Endotracheal Intubation in Hypertensive Patients Undergoing Surgery","Inclusion Criteria:\n\n* ASA Grade II\n* Age \\> 60 years\n* Elective surgical procedures under GA.\n* All patients with a diagnosis of hypertension for 6 months or more and undergoing treatment with antihypertensive medications.\n\nExclusion Criteria:\n\n* Patient refusal\n* ASA Grade III and IV\n* Severely Hypovolemic state\n* Emergency surgeries\n* Body weight more than 20% of ideal body weight.\n* Patients with known or unanticipated difficult intubation and those requiring more than 15 sec or two attempts at laryngoscopy\n* Allergic to dexmedetomidine\n* Non complaint hypertensive patients\n* Patients with uncontrolled hypertension.","ALL","60 Years",{"count":76,"type":77},60,"ESTIMATED","INTERVENTIONAL",[80,81],"PHASE1","PHASE2","Dexmedetomidine, an alpha-2 adrenergic agonist, has been shown to provide several benefits during endotracheal intubation:\n\n1. \\_Reduced anxiety and stress\\_: Dexmedetomidine's anxiolytic and sedative effects help reduce anxiety and stress associated with endotracheal intubation.\n2. \\_Improved intubating conditions\\_: Dexmedetomidine can improve intubating conditions by reducing the incidence of coughing, bucking, and laryngospasm.\n3. \\_Decreased hemodynamic responses\\_: Dexmedetomidine can attenuate the hemodynamic responses to intubation, including tachycardia, hypertension, and increased cardiac output.\n4. \\_Increased ease of intubation\\_: Dexmedetomidine can facilitate smoother and easier intubation by reducing the need for additional anesthetics or muscle relaxants.\n\nThe physiological responses to dexmedetomidine during intubation include:\n\n1. \\_Decreased heart rate\\_: Dexmedetomidine can cause a decrease in heart rate due to its effects on the sympathetic nervous system.\n2. \\_Decreased blood pressure\\_: Dexmedetomidine can also cause a decrease in blood pressure due to its vasodilatory effects.\n3. \\_Increased sedation\\_: Dexmedetomidine's sedative effects can help reduce anxiety and stress during intubation.\n4. \\_Reduced respiratory rate\\_: Dexmedetomidine can cause a decrease in respiratory rate due to its effects on the respiratory centers in the brain.\n\nThe clinical benefits of dexmedetomidine during intubation include:\n\n1. \\_Improved patient comfort\\_: Dexmedetomidine's sedative and anxiolytic effects can improve patient comfort during intubation.\n2. \\_Reduced need for additional anesthetics\\_: Dexmedetomidine can reduce the need for additional anesthetics or muscle relaxants during intubation.\n3. \\_Decreased risk of complications\\_: Dexmedetomidine's effects on hemodynamic responses and respiratory rate can decrease the risk of complications during intubation.",[84,85,86,87,88],"Elective Surgical Patient","Hypertensive Patients","Blood Pressure","Hypertensive Elderly Patients","Anxiolytic",[90,91,92,93,94,95,96,97,98,99,88],"Laryngoscopy","Dexmedetomidine","Hemodynamic Response","Endotracheal intubation","Pressor response","Hypertension","Intubation","General anesthesia","a 2 agonist","Sedative","2024-12-06",{"date":102,"type":103},"2024-12-11","ACTUAL",{"date":105,"type":103},"2024-06-22",{"date":107,"type":77},"2024-12-01",{"name":5,"class":6},1]