[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576618":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":36,"locations":11,"responsibleParty":42,"collaborators":11,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":11,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":70,"whyStopped":11,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":11},{"fullName":5,"class":6},"Aswan University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"full dose of Neostigmine","ACTIVE_COMPARATOR",null,[13],"Drug: full dose of Neostigmine",{"label":15,"type":10,"description":11,"interventionNames":16},"half dose of Neostigmine",[17],"Drug: half dose of Neostigmine",[19,23],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":11},"DRUG","• Group A: received 10ml (a full dose of Neostigmine (0.08 mg\u002Fkg) plus Atropine (20 mic\u002Fkg+7ml normal saline)\n\nMeasured using ultrasound Time frame: preoperatively and at zero, 10 minutes and 30 minutes postoperatively.",[9],{"type":20,"name":15,"description":24,"armGroupLabels":25,"otherNames":11},"• Group B: received 10ml (a half dose of Neostigmine (0.04 mg\u002Fkg) plus Atropine (20 mic\u002Fkg+8ml normal saline).\n\nMeasured using ultrasound Time frame: preoperatively and at zero, 10 minutes and 30 minutes postoperatively.",[15],[27,31,34],{"name":28,"affiliation":29,"role":30},"Ayman M El-demirdash","Anesthesia, surgical intensive care and pain management - Aswan University Hospital","STUDY_CHAIR",{"name":32,"affiliation":29,"role":33},"Hani M Raslan","STUDY_DIRECTOR",{"name":35,"affiliation":29,"role":33},"Zaher Z Zaher",[37],{"name":38,"role":39,"phone":40,"phoneExt":11,"email":41},"Sara A Mohamed","CONTACT","+201153006436","sara1704387@med.aswu.edu.eg",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Sara Abd El Dayem Mohamed Abed","Resident of anesthesia, surgical intensive care & pain management","100576618","phase-1-effects-of-neostigmine-dose-on-diaphragmatic-dynamics-100576618",false,"NCT06787638","Effects of Neostigmine-dose on Diaphragmatic Dynamics","Diaphragmatic Dynamics in Laparoscopic Cholecystectomy: Comparing Neuromuscular Blocker Reversal Strategies-A Randomized Trial","DTF\u002FDE\u002FAChE","Inclusion Criteria:\n\n* Adults scheduled for elective laparoscopic cholecystectomy.\n* Age: \\\u003C or = 18 years.\n* Both genders.\n* American Society Of Anesthiologists (ASA) I\u002FII patients.\n* BMI \\\u003C35\n\nExclusion Criteria:\n\n* Pre-existing diaphragmatic or respiratory disorders.\n* ASA III\u002FIV\n* BMI \\>35\n* Chronic opioid use or abuse\n* Pregnancy or breastfeeding",true,"ALL","18 Years","75 Years",{"count":59,"type":60},50,"ESTIMATED","INTERVENTIONAL",[63],"PHASE1","The goal of this Randomized Clinical Trial is to compare the postoperative diaphragmatic excursion between patients receiving half-dose neostigmine (0.04 mg\u002Fkg) and those receiving full-dose neostigmine (0.08 mg\u002Fkg) for neuromuscular blockade reversal.\n\nThe main questions it aims to answer are:\n\n* Does half-dose neostigmine result in similar postoperative diaphragmatic excursion compared to full-dose neostigmine?\n* Does half-dose neostigmine result in similar diaphragmatic thickening fraction compared to full-dose neostigmine? Researchers will compare patients receiving half-dose neostigmine to those receiving full-dose neostigmine to see if there are differences in postoperative diaphragmatic function, respiratory complications, and recovery.\n\nParticipants will:\n\n* Undergo elective laparoscopic cholecystectomy.\n* Receive either half-dose or full-dose neostigmine for neuromuscular blockade reversal.",[66],"Diaphragm Ultrasound",[68,69],"Diaphragmatic Thickening Fraction","Diaphragmatic Excursion","NOT_YET_RECRUITING","2025-01-16",{"date":73,"type":74},"2025-01-22","ACTUAL",{"date":76,"type":60},"2025-01-25",{"date":78,"type":60},"2026-04",{"name":5,"class":6}]