[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564070":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":36,"centralContacts":41,"locations":51,"responsibleParty":65,"collaborators":36,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":36,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":36,"enrollmentInfo":78,"targetDuration":36,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":90,"overallStatus":92,"whyStopped":36,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Isfahan University of Medical Sciences","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: Drug group (topical cyclosporine 0.05% and Lifitgrast)","ACTIVE_COMPARATOR","Group 1: In this group, cyclosporine 0.05% drops are poured into one eye and Lifitgrast drops are poured into the opposite eye.",[13],"Drug: Group 1 drug",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2: drug and placebo (cyclosporine 0.05%-Artlac)","Group 2: In this group, cyclosporine 0.05% drops are poured into one eye and artelac drops are poured into the opposite eye.",[18],"Drug: Group 2: Drug and placebo",{"label":20,"type":10,"description":21,"interventionNames":22},"Group 3: drug and placebo (Lifitgrast-Artlac)","Group 3: In this group, Lifitgrast drops are poured into one eye and artelac drops are poured into the opposite eye.",[23],"Drug: Group 3: Drug and palcebo",[25,32,37],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Group 1 drug","Group 1: In this group, the aim is to compare 2 drugs, cyclosporine 0.05% and Lifitgrast . In one eye, cyclosporine 0.05% eye drops are randomly poured and in the opposite eye, Lifitgrast eye drops are poured.",[9],[31],"drug",{"type":26,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Group 2: Drug and placebo","Group 2: In this group, the aim is to compare 2 drugs, cyclosporine 0.05% and Artelac artificial tear as a placebo. In one eye, cyclosporine 0.05% eye drops are randomly poured, and in the opposite eye, Artelac artificial tear are poured.",[15],null,{"type":26,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"Group 3: Drug and palcebo","Group 3: In this group, the aim is to compare 2 drugs, Lifitgrast and Artelac artificial tear as a placebo. In one eye, Lifitgrast eye drops are randomly poured, and in the opposite eye, Artelac artificial tear are poured.",[20],[42,47],{"name":43,"role":44,"phone":45,"phoneExt":36,"email":46},"Mohsen Pourazizi, Clinical Professor","CONTACT","0098 + 09126532785","m.pourazizi@yahoo.com",{"name":48,"role":44,"phone":49,"phoneExt":36,"email":50},"mohammad sadegh khalilian, Principal Investigator","0098 + 09379578055","m.khalilian74@gmail.com",[52],{"facility":53,"status":36,"city":54,"state":54,"zip":36,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Isfahan University of Medical Sciences, Feiz Hospital, Isfahan","Isfahan","Iran","IR",{"type":58,"coordinates":59},"Point",[60,61],51.67462,32.65246,{"lat":61,"lon":60},[64],{"name":43,"role":44,"phone":45,"phoneExt":36,"email":46},{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"SPONSOR_INVESTIGATOR","Mohsen Pourazizi","Assistant Professor of Ophthalmology","100564070","phase-1-efficacy-and-safety-of-topical-cyclosporine-005-and-lifitgrast-on-the-ocular-surface-symptom-after-photorefractive-keratectomy-in-feiz-hospital-isfahan-2024-100564070",false,"NCT06624384","Efficacy and Safety of Topical Cyclosporine 0.05% and Lifitgrast on the Ocular Surface Symptom After Photorefractive Keratectomy in Feiz Hospital, Isfahan, 2024","Efficacy and Safety of Topical Cyclosporine 0.05% (Restasis) and Lifitgrast (Xiidra) on the Ocular Surface Symptom After Photorefractive Keratectomy (PRK) in Feiz Hospital, Isfahan, 2024","Inclusion Criteria:\n\nAge above 18 years Myopia and myopic astigmatism The stability of the patients refraction over the past year Not using contact lenses at least 3 weeks before the operation Absence of history of KCN and any type of corneal ectasia in the patient himself or his first degree family No history of previous eye surgery and eye trauma Absence of active eye diseases, corneal dystrophy, retinal diseases, glaucoma, dry eyes of any degree.\n\nAbsence of systemic diseases that can potentially disrupt wound healing, including diabetes, vascular collagen diseases, and pregnancy.\n\nNot taking inhaled or systemic steroids actively or within 3 months before the procedure Absence of anisometropia Not using any systemic and topical analgesia during the last week\n\nExclusion Criteria:\n\nThe patients lack of consent to continue the study Failure to visit the patient for follow-up The occurrence of any complications during the patients surgery","ALL","18 Years",{"count":79,"type":80},150,"ESTIMATED","INTERVENTIONAL",[83],"PHASE1","The goal of this clinical trial is to compare the administration of 2 drugs, cyclosporine 0.05% (Restasis) and Lifitgrast (Xiidra) before PRK, in reducing the ocular surface symptom of patients after PRK. The main questions it aims to answer are:\n\n1- Does the use of cyclosporine 0.05% (Restasis) and Lifitgrast (Xiidra) before photorefractive keratectomy surgery (PRK) reduce ocular surface symptom such as eye pain, redness, and inflammation in conjunctivitis in patients? Researchers will compare cyclosporine 0.05% (Restasis) and Lifitgrast (Xiidra) to a placebo (Artelac artificial tears) to see if cyclosporine 0.05% and Lifitgrast works to reduce ocular surface symptom.\n\nParticipants will:\n\nTake drug cyclosporine 0.05% and Lifitgrast or a Artelac 30 minutes before surgery Visit the clinic 6 hours, one day, three days and one week after photorefractive keratectomy (PRK) for checkups and tests",[86,87,88,89],"Ocular Surface Symptom","Ocular Surface Disease","Eye Pain","Eye Inflammation",[91],"PRK- ocular surface symptom - cyclosporine 0.05% - Lifitgrast (Xiidra)","NOT_YET_RECRUITING","2024-09-30",{"date":95,"type":96},"2024-10-03","ACTUAL",{"date":98,"type":80},"2024-10-30",{"date":100,"type":80},"2024-12-30",{"name":67,"class":6},1]