[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100486192":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":38,"centralContacts":47,"locations":56,"responsibleParty":76,"collaborators":79,"id":88,"slug":89,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":30,"eligibilityCriteria":94,"healthyVolunteers":90,"sex":95,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":30,"studyType":101,"phases":102,"briefSummary":104,"conditions":105,"keywords":110,"overallStatus":59,"whyStopped":30,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"University of the Punjab","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Cultured ASCs enrichment fat grafting","EXPERIMENTAL","Fat graft will be supplemented with naïve ASCs",[13],"Biological: Cultured ASCs enrichment fat grafting",{"label":15,"type":10,"description":16,"interventionNames":17},"Curcumin-preconditioned ASCs enrichment fat grafting","Fat graft will be augmented with curcumin preconditioned ASCs",[18],"Biological: Curcumin-preconditioned ASCs enrichment fat grafting",{"label":20,"type":21,"description":22,"interventionNames":23},"conventional fat grafting","ACTIVE_COMPARATOR","Fat graft will not be supplemented with ex-vivo expanded ASCs",[24],"Other: Conventional fat grafting",[26,31,34],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"BIOLOGICAL","Patients will undergo conventional fat harvesting. Harvested fat will be mixed with cultured ASCs and grafted into recipient site with 1,00,000 cells\u002Fml injected fat",[9],null,{"type":27,"name":15,"description":32,"armGroupLabels":33,"otherNames":30},"Patients will undergo conventional fat harvesting. Harvested fat will be mixed with cultured ASCs preconditioned with curcumin and grafted into recipient site with 1,00,000 cells\u002Fml injected fat",[15],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":30},"Conventional fat grafting","Patients will undergo conventional fat harvesting and grafting of fat into recipient site",[20],[39,43],{"name":40,"affiliation":41,"role":42},"Azra Mehmood, PhD","Center of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore","PRINCIPAL_INVESTIGATOR",{"name":44,"affiliation":45,"role":46},"Sheikh Riazuddin, PhD","Jinnah Burn and Reconstructive Surgery Center (JB&RSC), Lahore","STUDY_DIRECTOR",[48,52],{"name":40,"role":49,"phone":50,"phoneExt":30,"email":51},"CONTACT","+92-333-4107008","azra_mehmood@hotmail.com",{"name":53,"role":49,"phone":54,"phoneExt":30,"email":55},"Amna Arif, M.Phil.","+92-333-4161068","amnaarif.qureshi@gmail.com",[57],{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Stem Cell Laboratory, Jinnah Burn and Reconstructive Surgery Center (JB&RSC)","RECRUITING","Lahore","Punjab Province","54550","Pakistan","PK",{"type":66,"coordinates":67},"Point",[68,69],74.35071,31.558,{"lat":69,"lon":68},[72],{"name":73,"role":49,"phone":74,"phoneExt":30,"email":75},"Dr. Moazzam Nazeer Tarar, Plastic Surgeon MBBS\u002F FRCS","+92-300-8423139","mntarar@gmail.com",{"type":42,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Azra Mehmood","Associate Professor",[80,83,85],{"name":81,"class":82},"Centre of Excellence in Molecular Biology, University of the Punjab, Lahore","UNKNOWN",{"name":84,"class":6},"Higher Education Commission (Pakistan)",{"name":86,"class":87},"Jinnah Burn and Reconstructive Surgery Centre, Lahore","OTHER_GOV","100486192","phase-1-efficacy-of-preconditioned-adipose-derived-stem-cells-in-fat-grafting-100486192",false,"NCT05610878","Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting","Supplementation of Autologous Fat Grafts with Curcumin Preconditioned Adipose-Derived Stem Cells in the Treatment of Facial Contour Deformities","Inclusion criteria\n\n* Age 18-50 years (male or female)\n* Body-mass index 20-30 kg\u002Fm²\n* Suitable for liposuction as assessed by the expected cosmetic results\n* Provided signed informed consent\n\nExclusion criteria\n\n* Systemic disorders include autoimmune diseases, hemorrhagic diseases, bone marrow aplasia, sepsis, cancer, and others\n* Local disorders include acne, infections and others\n* Risk factors include smoking, uncompensated diabetes, hypertension, and allergy to the drugs used for general anesthesia\n* Microbiological contamination of either the cell culture or the transplanted tissue","ALL","18 Years","50 Years",{"count":99,"type":100},24,"ESTIMATED","INTERVENTIONAL",[103],"PHASE1","The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.",[106,107,108,109],"Romberg Disease","Craniofacial Microsomia","Burn Scar","Post-Traumatic Scar (Disorder)",[111,112,113,114],"Facial deformities","Fat grafting","Adipose derived stem cells","Preconditioning","2024-12-30",{"date":117,"type":118},"2024-12-31","ACTUAL",{"date":120,"type":118},"2020-11-20",{"date":122,"type":100},"2025-12",{"name":5,"class":6},1]