[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573637":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":53,"collaborators":21,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":21,"enrollmentInfo":65,"targetDuration":21,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":78,"overallStatus":95,"whyStopped":21,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Medigene AG","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Administration of MDG1015","EXPERIMENTAL","MDG1015 is a first-in-class, 3rd generation TCR-T therapy consisting of autologous, patient-derived CD8+ T cells that are transduced with a New York esophageal squamous cell carcinoma-1 (NY-ESO-1)\u002F L antigen family member-1a (LAGE-1a)-specific, human leukocyte antigen (HLA)-A\\*02:01-restricted T cell receptor (TCR) and the costimulatory switch protein (CSP) programmed cell death protein 1 (PD1)-41BB administered following lymphodepletion chemotherapy.",[13,14],"Drug: Lymphodepletion","Biological: TCR-T cells (MDG1015)",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DRUG","Lymphodepletion","Cylcophosamide and Fludarabine",[9],null,{"type":23,"name":24,"description":24,"armGroupLabels":25,"otherNames":21},"BIOLOGICAL","TCR-T cells (MDG1015)",[9],[27],{"name":28,"affiliation":29,"role":30},"David Dr. Zhen, MD","Fred Hutch Cancer Center","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":21,"email":36},"Kirsty Dr. Crame, MD","CONTACT","+49892000330","k.crame@medigene.com",{"name":38,"role":34,"phone":21,"phoneExt":21,"email":39},"Marianne Seibt, BA","m.seibt@medigene.com",[41],{"facility":29,"status":21,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":21},"Seattle","Washington","98109","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-122.33207,47.60621,{"lat":51,"lon":50},{"type":54,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100573637","phase-1-epitome-1015-i-a-study-to-investigate-the-safety-and-tolerability-of-mdg1015-in-patients-with-epithelial-ovarian-cancer-gastroesophageal-adenocarcinoma-round-cell-liposarcoma-andor-synovial-sarcoma-100573637",false,"NCT06748872","EPITOME-1015-I: a Study to Investigate the Safety and Tolerability of MDG1015 in Patients with Epithelial Ovarian Cancer, Gastroesophageal Adenocarcinoma, Round Cell Liposarcoma And\u002For Synovial Sarcoma","EPITOME-1015-I: a Phase I Study to Investigate the Safety, Tolerability and Preliminary Efficacy of a Third Generation TCR-T Therapy, MDG1015, in Epithelial Ovarian Carcinoma, Gastroesophageal (Junction) Adenocarcinoma, Myxoid (Round Cell) Liposarcoma And\u002For Synovial Sarcoma Subjects with Advanced Disease Expressing NY-ESO-1 And\u002For LAGE-1a","EPITOME-1015-I","Inclusion Criteria:\n\n1. Adult, ≥ 18 years of age and weigh ≥ 40 kg for Dose levels 1-3 and ≥ 50 kg for Dose level 4\n2. Subject must have a confirmed diagnosis of either High grade serous or endometrioid ovarian, primary peritoneal or fallopian tube cancer Gastric or esophageal (junction) adenocarcinoma Myxoid (round cell) liposarcoma Synovial sarcoma\n3. Subject's must have tested positive for HLA-A\\*02:01 genotype by a Sponsor designated central laboratory\n4. Subject's tumor must have tested positive for NY-ESO-1 and\u002For LAGE-1a mRNA expression by a Sponsor designated central laboratory Both ≤1 year old archival tissue or fresh biopsy are allowed\n5. Subjects diagnosed with an eligible indication must have exhausted treatment options with proven survival benefit\n6. Subjects must have\n\n   1. measurable disease\n   2. Life expectancy ≥ 3 months per Investigator's opinion\n\n8\\. Eastern Cooperative Oncology Group (ECOG) performance status 0-1 9. Adequate vital organ function 10. Adequate bone marrow function 11. Adequate coagulation profile 12. Toxicities from prior\u002Fongoing therapies must have recovered to ≤ Grade 2 according to the CTCAE v5.0 or Subject's baseline excluding alopecia 14. Prior toxicities related to surgical procedures should have recovered to Grade ≤ 1 15. Women of childbearing potential (WCBP) or men who can father children must be willing and able to use adequate (e.g. barrier or licensed hormonal methods)\n\nExclusion Criteria:\n\n1. Any uncontrolled medical or psychiatric disorder that would preclude participation as outlined\n2. HLA-A\\*02:02 or HLA-A\\*02:03 genotype\n3. Pregnant or lactating women\n4. Viral serology:\n\n   1. Known infection with HIV-1\u002F2, CMV (CMV required only for U.S. sites) or HTLV-1\u002F2,\n   2. Active infection with HBV or HCV\n   3. Positive test for Mycoplasma or Treponema Pallidum\n5. Uncontrolled infection(s) requiring intravenous anti-bacterial, anti-viral or anti-fungal treatment within 14 days prior to the first dose of LDC (patients receiving prophylactic antibiotics are eligible)\n6. Inadequate venous access for or contraindications to leukapheresis\n7. Contraindications or life-threatening allergies, hypersensitivity, or intolerance to MDG1015 excipients, LDC agents, rasburicase, methylprednisolone or tocilizumab.\n8. Untreated CNS metastases or active CNS metastases (progressing or requiring corticosteroids for symptoms control) and leptomeningeal disease\n9. Unstable\u002Factive ulcer, varices, or digestive tract bleeding or recent digestive surgery that may have increased risk of bleeding\n10. History of another primary malignancy that requires intervention beyond surveillance or that has not been in remission for at least 1 year. The following are exempt from the 1-year limit:\n\n    1. non-melanoma skin cancer\n    2. curatively treated localized prostate cancer\n    3. carcinoma in situ (e.g. cervix, bladder, breast)\n11. NYHA Class ≥ II, heart failure, unstable angina, a history of recent (≤ 6 months) arrythmias, myocardial infarction or sustained (\\> 30 seconds) ventricular tachyarrhythmias\n12. Subjects who are dependent on dialysis\n13. Subjects with a history of pulmonary embolism or deep vein thrombosis that cannot safely withhold anti-coagulant therapy from leukapheresis until 7 days after administration of MDG1015 as determined by the Investigator\n14. Active autoimmune disease requiring systemic therapy except for adequately controlled Type 1 diabetes mellitus, autoimmune hypothyroidism or Grave's disease\n15. Previous allogeneic hematopoietic stem cell transplant within the last 5 years or solid organ transplant\n\n    Specific to GAC\u002FGEJ Subjects:\n16. Positive history of esophageal or gastric resection that the Investigator considers is at increased risk of bleeding or perforation","ALL","18 Years",{"count":66,"type":67},55,"ESTIMATED","INTERVENTIONAL",[70],"PHASE1","MDG1015 is a third generation TCR-T therapy product targeting NY-ESO-1\u002FLAGE-1a armored and enhanced by the PD1-41BB costimulatory switch protein (CSP). The study purpose is to establish the safety, tolerability and preliminary efficacy of MDG1015 in patients with epithelial ovarian cancer, gastroesophageal adenocarcinoma, round cell liposarcoma and\u002For synovial sarcoma that expresses NY-ESO-1 and\u002For LAGE-1a.\n\nThe main questions this clinical trial aims to answer are:\n\nCan this TCR-T therapy MDG1015 be given to patients safely? What is the optimal dose of the TCR-T therapy MDG1015? If and what side effects do participants experience after receiving the TCR-T therapy MDG1015? Do participants experience a potential disease response after receiving the TCR-T therapy MDG1015?\n\nParticipants will:\n\nReceive (in most cases) 1 single infusion of MDG1015 at a pre-defined dose level and will be followed up regularly up to 1 year. After one year, participants will enter the long term follow-up part up to 15 years after being treated. Any side effects and\u002For potential disease response will be documented during this period.",[73,74,75,76,77],"Epithelial Ovarian Cancer","Gastro-esophageal Junction Cancer","Soft Tissue Sarcoma (STS)","Myxoid Liposarcoma","Synovial Sarcoma",[79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94],"TCR-T Therapy","dose escalation","Third Generation TCR-T Therapy","autologous, patient derived CD8+ T cells","single arm","open label","phase I","BOIN design","NY-ESO-1","LAGE-1a","solid tumors","PD1-41BB","Costimulatory Switch Protein","Armoring","Enhancement","First-in-human","NOT_YET_RECRUITING","2024-12-23",{"date":98,"type":99},"2024-12-27","ACTUAL",{"date":101,"type":67},"2025-07-01",{"date":103,"type":67},"2042-08-01",{"name":5,"class":6},1]