[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566991":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":19,"locations":11,"responsibleParty":30,"collaborators":11,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":37,"acronym":38,"eligibilityCriteria":39,"healthyVolunteers":34,"sex":40,"minAge":41,"maxAge":42,"enrollmentInfo":43,"targetDuration":11,"studyType":46,"phases":47,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":61,"whyStopped":11,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":11},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Esophagus replacement","EXPERIMENTAL",null,[13],"Other: Replacement of the esophagus with a decellularized human esophagus graft",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":11},"Replacement of the esophagus with a decellularized human esophagus graft","The Decellularized Human Esophagus (DHE) will be surgically implanted under general anesthesia via right or left thoracotomy or cervicotomy, depending on the location of the stenosis, to replace the esophageal defect created by resection of the stenosis. An omentoplasty is performed laparoscopically beforehand to provide secondary coverage of the graft area. A temporary esophageal stent is placed endoscopically to cover the DHE and the two anastomoses for a period of 3 months, to prevent the development of an anastomotic fistula and stenosis of the graft area.",[9],[20,26],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},"Pierre Cattan, MD PhD","CONTACT","+33142499116","+33","pierre.cattan@aphp.fr",{"name":27,"role":22,"phone":28,"phoneExt":24,"email":29},"Jérôme Lambert, MD PhD","+33142499742","jerome.lambert@u-paris.fr",{"type":31,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100566991","phase-1-esophageal-replacement-with-a-decellularized-human-esophagus-graft-100566991",false,"NCT06662370","Esophageal Replacement With a Decellularized Human Esophagus Graft","Remplacement de l'œsophage Par Une Greffe d'œsophage Humain décellularisé","ESOGRAFT","Inclusion Criteria:\n\n* Age: 18 to 65\n* Caustic, traumatic, anastomotic, post-operative, radiation-induced or post-endoscopic (mucosal resection, submucosal dissection) benign esophageal stricture refractory to endoscopic dilatation.\n* For women: effective contraception for the entire duration of the study (from signature of consent to end of follow-up)\n* Affiliated or beneficiary of a social security scheme.\n* Free written consent signed by the participant and the investigator.\n\nExclusion Criteria:\n\n* Weight loss \\> 10% of body weight over last 3 months\n* Stenosis \\> 5 cm in length\n* Multiple strictures\n* Esophageal mouth stenosis\n* Anterior surgery close to the operative zone\n* Complete anterior omentectomy\n* Tumour stenosis or progressive tumour pathology\n* Non-stabilized psychiatric disorders\n* Participation in another interventional study\n* Pregnant or breast-feeding women\n* Women of childbearing age without effective contraceptive measures:\n\nAll women of childbearing age must have a negative pregnancy test prior to treatment and must agree to maintain highly effective contraception using contraceptive measures from the date of consent until 12 months due to the risks associated with anesthesia during endoscopy\n\n* Uncontrolled sepsis\n* Related to the transplant procedure\n\n  * ASA score ≥ 3,\n  * Severe respiratory insufficiency (FEV1 \\\u003C 1 L),\n  * Decompensated hepatic cirrhosis or presence of esophageal varices,\n  * Chronic renal insufficiency (creatinine \\> 1.25 N),\n  * Myocardial infarction less than 6 months old or progressive heart disease,\n  * WHO general condition \\> 2,\n  * Weight loss \\>20% not recovered after renutrition.\n* Contraindication to general anaesthesia, analgesics and antibiotics.\n* Conditions requiring long-term immunosuppressive or corticosteroid treatment.\n* Patients under curatorship or guardianship","ALL","18 Years","65 Years",{"count":44,"type":45},24,"ESTIMATED","INTERVENTIONAL",[48,49],"PHASE1","PHASE2","The aim of the study is to analyze over a 12 month-period, the safety and the efficacy of a circumferentiel oesophageal replacement of the esophagus by a decelularized human esophagus, in 24 patient with a short esophageal stenosis refractory to endoscopic dilatations.",[52],"Esophageal Stenosis",[54,55,56,57,58,59,60],"Tissue engineering","Esophageal replacement","Esophageal stenosis","Caustic injury","Radiotherapy","Anastomotic stenosis","Esophageal stent","NOT_YET_RECRUITING","2024-10-25",{"date":64,"type":65},"2024-10-28","ACTUAL",{"date":67,"type":45},"2024-11-01",{"date":69,"type":45},"2030-01-01",{"name":5,"class":6}]