[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607276":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":11,"centralContacts":11,"locations":25,"responsibleParty":46,"collaborators":11,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":11,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":11,"enrollmentInfo":57,"targetDuration":11,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":11,"overallStatus":28,"whyStopped":11,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Hansoh BioMedical R&D Company","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"HS-20093 + Itraconazole","EXPERIMENTAL",null,[13,14],"Drug: HS-20093","Drug: Itraconazole",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":11},"DRUG","HS-20093","All participants will receive intravenous infusion of HS-20093 at a dose of 8 mg\u002Fkg every 3 weeks (Q3W), with each treatment cycle lasting 21 days.",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"Itraconazole","Participants will then take itraconazole capsules orally at 200 mg per dose during C2D17-C3D21",[9],[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Hunan Cancer Hospital","RECRUITING","Changsha","Hunan","410013","China","CN",{"type":35,"coordinates":36},"Point",[37,38],112.97087,28.19874,{"lat":38,"lon":37},[41],{"name":42,"role":43,"phone":44,"phoneExt":11,"email":45},"Feng Yang, MD","CONTACT","86-731-89762695","hnszlyy_irb@163.com",{"type":47,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100607276","phase-1-evaluation-of-the-effect-of-itraconazole-on-the-pharmacokinetics-of-hs-20093-in-patients-with-advanced-solid-tumors-100607276",false,"NCT07186452","Evaluation of the Effect of Itraconazole on the Pharmacokinetics of HS-20093 in Patients With Advanced Solid Tumors","A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics of HS-20093 in Patients With Advanced Solid Tumors Who Have Failed Adequate Standard Treatments or Are Intolerant to Standard Therapies","Inclusion Criteria:\n\n1. Histologically or cytologically confirmed advanced solid tumors that have failed standard therapy or are intolerant to standard treatment.\n2. According to RECIST 1.1 criteria, participants must have at least one target lesion.\n3. ECOG performance status score of 0-1 with no deterioration within 2 weeks prior to the first dose.\n4. Minimum expected survival greater than 12 weeks.\n\nExclusion Criteria:\n\n1. Patients with a contraindication for receiving itraconazole according to the prescribing information\n2. Patients with severe, uncontrolled, or active cardiovascular diseases","ALL","18 Years",{"count":58,"type":59},18,"ESTIMATED","INTERVENTIONAL",[62],"PHASE1","The primary objective of this study is to evaluate the effect of itraconazole on the pharmacokinetics of HS-20093 in patients with advanced solid tumors.",[65],"Advanced Solid Tumors","2026-01-15",{"date":68,"type":69},"2026-01-16","ACTUAL",{"date":71,"type":69},"2025-09-23",{"date":73,"type":59},"2026-08-31",{"name":5,"class":6},1]