[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505178":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":28,"locations":38,"responsibleParty":56,"collaborators":58,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":20,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":20,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":103,"overallStatus":40,"whyStopped":20,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Florida International University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Functional Precision Medicine for Chemorefractory or relapsed patients","EXPERIMENTAL","We intend to enroll chemorefractory or relapsed pediatric patients with all types of cancers where tumor tissue would be available for functional precision medicine that integrates ex vivo drug screening and genomic profiling. The results of the drug sensitivity assay and genetic screening will be used to inform treating physician about patient-specific drug sensitivity or resistance guiding best therapy choices.",[13],"Device: Functional Precision Medicine",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Functional Precision Medicine","Ex Vivo Drug Sensitivity Testing + Genomic Tumor Profiling",[9],null,[22,25],{"name":23,"affiliation":5,"role":24},"Diana Azzam","PRINCIPAL_INVESTIGATOR",{"name":26,"affiliation":27,"role":24},"Maggie Fader","Nicklaus Children's Hospital",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":20,"email":33},"Diana Azzam, PhD","CONTACT","305-348-9043","fpmlab@fiu.edu",{"name":35,"role":31,"phone":36,"phoneExt":20,"email":37},"Lillian Garvin","800-533-1792","exvivotrial@nicklaushealth.org",[39],{"facility":27,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Miami","Florida","33155","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-80.19366,25.77427,{"lat":50,"lon":49},[53,55],{"name":54,"role":31,"phone":36,"phoneExt":20,"email":37},"Darika Sartmatova",{"name":35,"role":31,"phone":36,"phoneExt":20,"email":37},{"type":24,"investigatorFullName":30,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Assistant Professor",[59,61,64],{"name":60,"class":6},"Nicklaus Children's Hospital f\u002Fk\u002Fa Miami Children's Hospital",{"name":62,"class":63},"First Ascent Biomedical Inc.","INDUSTRY",{"name":65,"class":66},"National Institute on Minority Health and Health Disparities (NIMHD)","NIH","100505178","phase-1-ex-vivo-drug-sensitivity-testing-and-multi-omics-profiling-100505178",false,"NCT05857969","Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling","Adopting a Functional Precision Medicine Approach For Individualized Pediatric Cancer Treatments","Inclusion Criteria:\n\n* Patients aged 21 years or younger at the time of enrollment on this study of any gender, race or ethnicity.\n\nSubjects with suspected or confirmed diagnosis of recurrent or refractory cancer Subjects who are scheduled for or have recently had biopsy or tumor excised (solid tumors) or bone marrow aspirate (blood cancers) Subjects willing to have a blood draw or buccal swab done for the purposes of genetic testing Subjects or their parents or legal guardians willing to sign informed consent Subjects aged 7 to 17 willing to sign assent\n\nExclusion Criteria:\n\n* Subjects who do not have malignant tissue available and accessible The amount of excised malignant tissue is not sufficient for the ex vivo drug testing and\u002For genetic profiling.\n\nPatients with newly diagnosed tumors and tumors that have high (\\>90%) cure rate with safe standard therapy.","ALL","1 Day","21 Years",{"count":78,"type":79},65,"ESTIMATED","INTERVENTIONAL",[82],"PHASE1","Functional precision medicine (FPM) is a relatively new approach to cancer therapy based on direct exposure of patient- isolated tumor cells to clinically approved drugs and integrates ex vivo drug sensitivity testing (DST) and genomic profiling to determine the optimal individualized therapy for cancer patients. In this study, we will enroll relapsed or refractory pediatric cancer patients with tissue available for DST and genomic profiling from the South Florida area, which is 69% Hispanic and 18% Black. Tumor cells collected from tissue taken during routine biopsy or surgery will be tested.",[85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102],"Recurrent Childhood Acute Myeloid Leukemia","Recurrent Childhood Acute Lymphoblastic Leukemia","Recurrent Childhood Large Cell Lymphoma","Refractory Childhood Acute Lymphoblastic Leukemia","Refractory Childhood Hodgkin Lymphoma","Refractory Childhood Malignant Germ Cell Neoplasm","Recurrent Childhood Brain Tumor","Recurrent Childhood Brainstem Glioma","Recurrent Childhood Rhabdomyosarcoma","Recurrent Childhood Soft Tissue Sarcoma","Recurrent Childhood Ependymoma","Recurrent Childhood Lymphoblastic Lymphoma","Recurrent Childhood Gliosarcoma","Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive","Refractory Childhood Malignant Solid Neoplasm","Recurrent Childhood Malignant Solid Neoplasm","Recurrent Childhood Malignant Neoplasm","Refractory Childhood Malignant Neoplasm",[104,105,106,107],"ex vivo drug sensitivity assay","genomic profiling","Functional precision medicine","Biomarker development","2025-07-08",{"date":110,"type":111},"2025-07-11","ACTUAL",{"date":113,"type":111},"2023-02-22",{"date":115,"type":79},"2028-12-31",{"name":5,"class":6},1]