[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053325":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":51,"centralContacts":56,"locations":62,"responsibleParty":111,"collaborators":113,"id":116,"slug":117,"hasResults":118,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":30,"eligibilityCriteria":122,"healthyVolunteers":118,"sex":123,"minAge":124,"maxAge":125,"enrollmentInfo":126,"targetDuration":30,"studyType":129,"phases":130,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":65,"whyStopped":30,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":148},{"fullName":5,"class":6},"University of Maryland, Baltimore","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Study group - Wearable ankle robot rehab","EXPERIMENTAL","Wearable rehab robot with motor relearning with real-time feedback, passive stretching under intelligent control; Active movement training with robotic assistance",[13,14,15],"Device: Motor relearning training","Device: Passive stretching","Device: Gamed-based active movement training",{"label":17,"type":18,"description":19,"interventionNames":20},"Control group - Limited wearable ankle robot rehab","ACTIVE_COMPARATOR","The same wearable robot used by the study group will be used for the control group but in a limited way: no motor relearning training under real-time feedback; passive movement in the joint middle range of motion instead of passive stretching; active movement training with no robotic assistance",[21,22,23],"Device: Passive movement","Device: Active movement training","Device: Ankle torque and motion measurement",[25,31,35,39,43,47],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Motor relearning training","Ankle motor control relearning training under real-time feedback",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Passive stretching","Passive stretching under intelligent robotic control",[9],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Gamed-based active movement training","Active movement training through movement games with robotic assistance",[9],{"type":26,"name":40,"description":41,"armGroupLabels":42,"otherNames":30},"Passive movement","Passive movement in the joint middle range of motion",[17],{"type":26,"name":44,"description":45,"armGroupLabels":46,"otherNames":30},"Active movement training","Active movement training without robotic assistance",[17],{"type":26,"name":48,"description":49,"armGroupLabels":50,"otherNames":30},"Ankle torque and motion measurement","Ankle torque and motion measurement with no real-time feedback",[17],[52],{"name":53,"affiliation":54,"role":55},"Li-Qun Zhang","University of Maryland","PRINCIPAL_INVESTIGATOR",[57],{"name":58,"role":59,"phone":60,"phoneExt":30,"email":61},"Peiwen Fu, BS","CONTACT","410 706-8625","Peiwen.Fu@som.umaryland.edu",[63,83,94],{"facility":64,"status":65,"city":66,"state":67,"zip":68,"country":69,"countryCode":70,"cosmosGeoPoint":71,"geoPoint":76,"contacts":77},"University of Maryland Baltimore","RECRUITING","Baltimore","Maryland","21201","United States","US",{"type":72,"coordinates":73},"Point",[74,75],-76.61219,39.29038,{"lat":75,"lon":74},[78,80,81],{"name":79,"role":59,"phone":30,"phoneExt":30,"email":30},"Dali Xu, PhD",{"name":58,"role":59,"phone":30,"phoneExt":30,"email":30},{"name":82,"role":55,"phone":30,"phoneExt":30,"email":30},"Li-Qun Larry Zhang, PhD",{"facility":84,"status":65,"city":66,"state":67,"zip":85,"country":69,"countryCode":70,"cosmosGeoPoint":86,"geoPoint":88,"contacts":89},"UMROI","21207",{"type":72,"coordinates":87},[74,75],{"lat":75,"lon":74},[90,92],{"name":91,"role":59,"phone":30,"phoneExt":30,"email":30},"Dali Xu",{"name":93,"role":59,"phone":30,"phoneExt":30,"email":30},"Peiwen Fu",{"facility":95,"status":65,"city":96,"state":97,"zip":98,"country":69,"countryCode":70,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"TIRR Memorial Hermann","Houston","Texas","77030",{"type":72,"coordinates":100},[101,102],-95.36327,29.76328,{"lat":102,"lon":101},[105,109],{"name":106,"role":59,"phone":107,"phoneExt":30,"email":108},"Manuel Portilla-Jimenez, PhD","346-719-4921","manuel.a.portillajimenez@uth.tmc.edu",{"name":110,"role":55,"phone":30,"phoneExt":30,"email":30},"Sheng Li, MD-PhD",{"type":55,"investigatorFullName":53,"investigatorTitle":112,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Professor",[114],{"name":115,"class":6},"The University of Texas Health Science Center, Houston","100053325","phase-1-facilitating-neuroplastic-changes-of-acute-stroke-survivors-100053325",false,"NCT06404268","Facilitating Neuroplastic Changes of Acute Stroke Survivors","Facilitating Neuroplastic Changes of Acute Stroke Survivors With Severe Hemiplegia","Inclusion Criteria:\n\n* Acute first time unilateral hemispheric stroke (hemorrhagic or ischemic stroke, 24 hours after admission to 1 month post-stroke at the start of the proposed treatment)\n* Hemiplegia or hemiparesis\n* 0≤Manual Muscle Testing (MMT)\\\u003C=2\n* Age 30-85\n* Ankle impairments including stiff calf muscles and\u002For inadequate dorsiflexion\n\nExclusion Criteria:\n\n* Medically not stable\n* Associated acute medical illness that interferes with ability to training and exercise\n* No impairment or very mild ankle impairment of ankle\n* Severe cardiovascular problems that interfere with ability to perform moderate movement exercises\n* Cognitive impairment or aphasia with inability to follow instructions\n* Severe pain in legs\n* Severe ankle contracture greater than 15° plantar flexion (when pushing ankle to dorsiflexion)\n* Pressure ulcer, recent surgical incision or active skin disease with open wounds present below knee","ALL","30 Years","85 Years",{"count":127,"type":128},68,"ESTIMATED","INTERVENTIONAL",[131,132],"PHASE1","PHASE2","This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage post-stroke including patients who are paralyzed with no motor output. The early acute stroke rehabilitation device will be evaluated in this clinical trial.",[135],"Stroke",[135,137,138],"Paraplegia","Acute","2026-07-10",{"date":141,"type":142},"2026-07-13","ACTUAL",{"date":144,"type":142},"2025-07-01",{"date":146,"type":128},"2028-12-31",{"name":5,"class":6},3]