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the Investigator.\n* Adequate organ and bone marrow function\n* Have adequate archival tumor tissue sample available or be approved by the Sponsor for enrollment if no tumor sample is available.\n* At least 1 measurable lesion based on RECIST version 1.1.\n\nAdditional Cohort-specific key inclusion criteria:\n\nPart A\n\n* Participants with HR+\u002FHER2- locally advanced, unresectable or metastatic breast cancer, must have received at least 1 prior line of hormonal therapy and at least 1 prior line of CDK4\u002F6-inhibitor in the advanced or metastatic setting.\n* Participants with HER2+ locally advanced, unresectable or metastatic breast cancer, must have received prior taxane, trastuzumab, pertuzumab, and tucatinib. Prior trastuzumab deruxtecan is allowed but not required.\n* Participants with HER2-low breast cancer must have received prior trastuzumab deruxtecan.\n* Participants with colorectal cancer must have KRAS wild-type disease.\n\nPart B\n\n* Participants with locally advanced, unresectable or metastatic HR+\u002FHER2- breast cancer must have received at least 1 prior line of hormonal therapy in the advanced or metastatic setting and at least 1 prior CDK4\u002F6-inhibitor.\n* Participants with HER2-low breast cancer should have received prior trastuzumab deruxtecan\n\nPart C ● Participants with HR±\u002FHER2+ locally advanced, unresectable or metastatic breast cancer must have received prior taxane, trastuzumab, and pertuzumab unless unavailable in the region or contraindicated. 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