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Gemelli IRCCS - Universita Cattolica del Sacro Cuore","Roma","00168",{"type":69,"coordinates":634},[635,636],11.10642,44.99364,{"lat":636,"lon":635},{"facility":639,"status":62,"city":640,"state":42,"zip":641,"country":642,"countryCode":643,"cosmosGeoPoint":644,"geoPoint":648,"contacts":42},"National Cancer Center Hospital East","Chiba","277-8577","Japan","JP",{"type":69,"coordinates":645},[646,647],140.11667,35.6,{"lat":647,"lon":646},{"facility":650,"status":62,"city":651,"state":42,"zip":652,"country":642,"countryCode":643,"cosmosGeoPoint":653,"geoPoint":657,"contacts":42},"Aichi Cancer Center Hospital","Nagoya","464-8681",{"type":69,"coordinates":654},[655,656],136.90641,35.18147,{"lat":656,"lon":655},{"facility":659,"status":62,"city":660,"state":42,"zip":661,"country":642,"countryCode":643,"cosmosGeoPoint":662,"geoPoint":666,"contacts":42},"National Cancer Center Hospital","Tokyo","104-0045",{"type":69,"coordinates":663},[664,665],139.69171,35.6895,{"lat":665,"lon":664},{"facility":668,"status":62,"city":660,"state":42,"zip":669,"country":642,"countryCode":643,"cosmosGeoPoint":670,"geoPoint":672,"contacts":42},"Cancer Institute Hospital of JFCR","135-8550",{"type":69,"coordinates":671},[664,665],{"lat":665,"lon":664},{"facility":674,"status":62,"city":675,"state":42,"zip":676,"country":677,"countryCode":678,"cosmosGeoPoint":42,"geoPoint":42,"contacts":42},"Erasmus MC","GE Rotterdam","3015","Netherlands","NL",{"facility":680,"status":62,"city":681,"state":42,"zip":682,"country":683,"countryCode":684,"cosmosGeoPoint":685,"geoPoint":689,"contacts":42},"Haukeland University Hospital","Bergen","5021","Norway","NO",{"type":69,"coordinates":686},[687,688],5.32415,60.39299,{"lat":688,"lon":687},{"facility":691,"status":62,"city":692,"state":42,"zip":693,"country":683,"countryCode":684,"cosmosGeoPoint":694,"geoPoint":698,"contacts":42},"Oslo University Hospital","Oslo","0450",{"type":69,"coordinates":695},[696,697],10.74609,59.91273,{"lat":697,"lon":696},{"facility":700,"status":62,"city":701,"state":42,"zip":702,"country":703,"countryCode":42,"cosmosGeoPoint":704,"geoPoint":708,"contacts":42},"Seoul National University Hospital","Seoul","03080","South Korea",{"type":69,"coordinates":705},[706,707],126.9784,37.566,{"lat":707,"lon":706},{"facility":710,"status":62,"city":701,"state":42,"zip":711,"country":703,"countryCode":42,"cosmosGeoPoint":712,"geoPoint":714,"contacts":42},"Severance Hospital, Yonsei University Health System","03722",{"type":69,"coordinates":713},[706,707],{"lat":707,"lon":706},{"facility":716,"status":62,"city":701,"state":42,"zip":717,"country":703,"countryCode":42,"cosmosGeoPoint":718,"geoPoint":720,"contacts":42},"Asan Medical Center","05505",{"type":69,"coordinates":719},[706,707],{"lat":707,"lon":706},{"facility":722,"status":62,"city":701,"state":42,"zip":723,"country":703,"countryCode":42,"cosmosGeoPoint":724,"geoPoint":726,"contacts":42},"Samsung Medical Center","06351",{"type":69,"coordinates":725},[706,707],{"lat":707,"lon":706},{"facility":728,"status":62,"city":729,"state":42,"zip":730,"country":731,"countryCode":732,"cosmosGeoPoint":733,"geoPoint":737,"contacts":42},"Institut Catala d'Oncologia - L'Hospitalet","Barcelona","08908","Spain","ES",{"type":69,"coordinates":734},[735,736],2.15899,41.38879,{"lat":736,"lon":735},{"facility":739,"status":62,"city":740,"state":42,"zip":741,"country":731,"countryCode":732,"cosmosGeoPoint":742,"geoPoint":746,"contacts":42},"Fundacion MD Anderson International Espana","Madrid","28033",{"type":69,"coordinates":743},[744,745],-3.70256,40.4165,{"lat":745,"lon":744},{"facility":748,"status":62,"city":740,"state":42,"zip":749,"country":731,"countryCode":732,"cosmosGeoPoint":750,"geoPoint":752,"contacts":42},"Hospital Universitario 12 de Octubre","28041",{"type":69,"coordinates":751},[744,745],{"lat":745,"lon":744},{"facility":754,"status":62,"city":740,"state":42,"zip":755,"country":731,"countryCode":732,"cosmosGeoPoint":756,"geoPoint":758,"contacts":42},"South Texas Accelerated Research Therapeutics (START) Madrid - CIOCC","28050",{"type":69,"coordinates":757},[744,745],{"lat":745,"lon":744},{"facility":760,"status":62,"city":761,"state":42,"zip":762,"country":731,"countryCode":732,"cosmosGeoPoint":763,"geoPoint":767,"contacts":42},"Hospital Universitario Marques De Valdecilla","Santander","39008",{"type":69,"coordinates":764},[765,766],-3.80493,43.46589,{"lat":766,"lon":765},{"facility":769,"status":62,"city":770,"state":42,"zip":771,"country":772,"countryCode":773,"cosmosGeoPoint":774,"geoPoint":778,"contacts":42},"The Christie NHS Foundation Trust","Manchester","M20 4BX","United Kingdom","UK",{"type":69,"coordinates":775},[776,777],-2.23743,53.48095,{"lat":777,"lon":776},{"facility":780,"status":62,"city":781,"state":42,"zip":782,"country":772,"countryCode":773,"cosmosGeoPoint":783,"geoPoint":787,"contacts":42},"Sheffield Teaching Hospitals NHS Foundation Trust","Sheffield","S10 2SB",{"type":69,"coordinates":784},[785,786],-1.4659,53.38297,{"lat":786,"lon":785},{"type":789,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100486489","phase-1-forager-1-a-study-of-loxo-435-ly3866288-in-participants-with-cancer-with-a-change-in-a-gene-called-fgfr3-100486489",false,"NCT05614739","FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3","FORAGER-1: A Phase 1, Open-Label, Multicenter Study of LOXO-435 (LY3866288) in Locally Advanced or Metastatic Solid Tumors Including Urothelial Cancer With FGFR3 Alterations","FORAGER-1","Inclusion Criteria:\n\n* Have solid tumor cancer with an FGFR3 pathway alteration on molecular testing in tumor or blood sample that is deemed as actionable\n\n  * Cohort A1: Presence of an alteration in FGFR3 or its ligands\n  * Cohort A2, B2, B3, and B5: Histological diagnosis of urothelial cancer (UC) that is locally advanced or metastatic with a qualifying FGFR3 genetic alteration\n  * Cohorts B1 and B4: Histological diagnosis of urothelial cancer that is locally advanced or metastatic\n  * Cohort C1: Must have histological diagnosis of a non-urothelial solid tumor malignancy that is locally advanced or metastatic with a qualifying FGFR3 genetic alteration\n* Measurability of disease:\n\n  * Cohort A1 and B3: Measurable or non-measurable disease as defined by Response Evaluation Criteria in Solid Tumors v 1.1 (RECIST v1.1)\n  * Cohorts A2, B1, B2, B4, B5, and C1: Measurable disease required as defined by RECIST v1.1\n* Have adequate tumor tissue sample available. Participants with inadequate tissue sample availability may still be considered for enrollment upon review\n* Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 for Cohorts A1, A2, B3, and B5\n\n  * Less than or equal to 2 for Cohorts B1, B2, B4, and C1\n* Prior Systemic Therapy Criteria:\n\n  * Cohort A1\u002FC1: Participant has received all standard therapies for which the participant was deemed to be an appropriate candidate by the treating Investigator; OR the participant is refusing the remaining most appropriate standard of care treatment; OR there is no standard therapy available for the disease. There is no restriction on number of prior therapies.\n  * Cohort A2, B2, B3 participants must have received at least one prior regimen, and cohorts B1 and B4 participants at least 2 prior regimens, in the locally advanced or metastatic setting\n  * There is no restriction on number of prior therapies\n* Cohort B5: Participants have not received prior systemic therapy for locally advanced or metastatic UC\n* FGFR inhibitor specific requirements:\n\n  * Cohort A1\u002FA2\u002FB3: Prior FGFR inhibitor treatment is permitted but not required\n  * Cohort B1\u002FB4: Participants must have been previously treated with erdafitinib\n  * Cohort B2, B5, and C1: Participants must be FGFR inhibitor naïve\n\nExclusion Criteria:\n\n* Participants with primary central nervous system (CNS) malignancy\n* Untreated or uncontrolled CNS metastases\n* Current evidence of corneal keratopathy or retinal disorder. Individuals with asymptomatic ophthalmic conditions may be eligible\n* Any serious unresolved toxicities from prior therapy\n* Significant cardiovascular disease\n* Prolongation of the QT interval corrected for heart rate using Fridericia's formula (QTcF)\n* Active uncontrolled systemic infection or other clinically significant medical conditions\n* Participants who are pregnant, lactating, or plan to breastfeed during the study or within 6 months of the last dose of study treatment. Participants who have stopped breastfeeding may be enrolled","ALL","18 Years",{"count":801,"type":802},535,"ESTIMATED","INTERVENTIONAL",[805],"PHASE1","The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435 by itself or when it is combined with other standard medicines that treat cancer. LOXO-435 may be used to treat cancer of the cells that line the urinary system and other solid tumor cancers that have a change in a particular gene (known as the FGFR3 gene). Participation could last up to 30 months (2.5 years) and possibly longer if the disease does not get worse.",[808,809,810],"Urinary Bladder Neoplasms","Neoplasm Metastasis","Ureteral Neoplasms",[812,813,814,815,816,817],"Bladder Cancer","Bladder Urothelial Carcinoma","Urinary Bladder Cancer","Urinary Tract Cancer","Renal Pelvis Cancer","Ureter Cancer","2026-06-17",{"date":820,"type":821},"2026-06-18","ACTUAL",{"date":823,"type":821},"2023-01-12",{"date":825,"type":802},"2027-06",{"name":5,"class":6},82]