[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521453":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":33,"locations":40,"responsibleParty":57,"collaborators":59,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":32,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":32,"enrollmentInfo":74,"targetDuration":32,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":43,"whyStopped":32,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Yale University","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1","EXPERIMENTAL","bupivacaine 0.0%, 0.01%, and 0.05% in random order, one week apart each",[13],"Drug: Bupivacaine Injection",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2","bupivacaine 0.1%, 0.05%, and 0.1% in random order, one week apart each",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Group 3","bupivacaine 0.0%, 0.1%, and 0.5% in random order, one week apart each",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Group 4","bupivacaine \\[0.01% or 0.05%\\], \\[0.05% or 0.1%\\], and 0.05% in random order, one week apart each",[13],[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","Bupivacaine Injection","subcutaneous injection around bilateral greater occipital nerves",[9,15,19,23],null,[34],{"name":35,"role":36,"phone":37,"phoneExt":38,"email":39},"Emmanuelle Schindler, MD, PhD","CONTACT","203-932-5711","4335","emmanuelle.schindler@va.gov",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"VA Connecticut Healthcare System","RECRUITING","West Haven","Connecticut","06516","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-72.94705,41.27065,{"lat":53,"lon":52},[56],{"name":35,"role":36,"phone":37,"phoneExt":38,"email":39},{"type":58,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[60,62],{"name":42,"class":61},"FED",{"name":63,"class":64},"National Headache Foundation","UNKNOWN","100521453","phase-1-greater-occipital-nerve-blockade-in-veterans-with-post-concussion-headache-sub-study-1-100521453",false,"NCT06069791","Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1","Anesthetic Greater Occipital Nerve Blockade in Veterans With Post-Traumatic Headache: Sub-study 1","Inclusion Criteria:\n\n* United States Military Veterans within VA Connecticut Healthcare System\n* Chronic post-traumatic headache per ICHD-3 criteria (i.e., headaches are continuing to occur three months after the head injury)\n* At least two headache days per week\n* MRI brain scan completed within the past 3 months if chronic PTH for less than one year, within the past year if chronic PTH for less than 5 years, and within 5 years if chronic PTH for more than 10 years\n* Review of MRI and the medical record does not reveal another source for headache\n\nExclusion Criteria:\n\n* Skull defect\n* Other contraindication to bupivacaine\n\n  1. Allergy or adverse reaction (e.g., rash, cardiac effects) to amide anesthetics, such as lidocaine\n  2. Instruction from clinician to avoid amide anesthetics, such as lidocaine\n* Pregnant or lack of adequate birth control","ALL","18 Years",{"count":75,"type":76},12,"ESTIMATED","INTERVENTIONAL",[79],"PHASE1","The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared. Each Veteran participant will be randomized to receive three different concentrations, which will be injected one week apart each.",[82],"Post-Traumatic Headache",[84,85,42],"traumatic brain injury","veteran","2026-01-27",{"date":88,"type":89},"2026-01-29","ACTUAL",{"date":91,"type":89},"2024-01-26",{"date":93,"type":76},"2026-12-31",{"name":5,"class":6},1]