[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631475":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":19,"locations":25,"responsibleParty":42,"collaborators":11,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":11,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":11,"studyType":57,"phases":58,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":28,"whyStopped":11,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Shenzhen Geno-Immune Medical Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"H3K27M-EIEs","EXPERIMENTAL",null,[13],"Biological: H3K27M-EIEs",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":11},"BIOLOGICAL","1 to 2 infusions, once a week, for 1x10\\^5\\~1x10\\^7 EIEs\u002Fkg via intravenous injection each time",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":11,"email":24},"Lung-Ji Chang, Ph.D","CONTACT","+86 0755-86573763","c@szgimi.org",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Shenzhen Geno-immune Medical Institute","RECRUITING","Shenzhen","Guangdong","518000","China","CN",{"type":35,"coordinates":36},"Point",[37,38],114.0683,22.54554,{"lat":38,"lon":37},[41],{"name":21,"role":22,"phone":23,"phoneExt":11,"email":24},{"type":43,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100631475","phase-1-h3k27m-specific-immune-effector-cells-targeting-dmgdipg-100631475",false,"NCT07501156","H3K27M-specific Immune Effector Cells Targeting DMG\u002FDIPG","H3K27M-specific Engineered Immune Effectors (EIE) Targeting Diffuse Midline Glioma\u002FDiffuse Intrinsic Pontine Glioma","Inclusion Criteria:\n\n1. Abilities to understand and the willingness to provide written informed consent;\n2. ≥ 2 and ≤ 70 years old;\n3. Recurrent or refractory diffuse midline glioma or diffuse intrinsic pontine glioma patients with confirmed H3K27M mutation and documented lesions. Patients have received standard care of medication, such as gross total resection with concurrent radio-chemotherapy (\\~54 - 60 Gy, TMZ). Patients must either not be receiving dexamethasone or receiving ≤ 4 mg\u002Fday at the time of leukopheresis;\n4. Karnofsky performance score (KPS) ≥ 60;\n5. Life expectancy \\>3 months;\n6. Satisfactory bone marrow, liver and kidney functions as defined by the following: absolute neutrophile count ≥ 1500\u002Fmm\\^3; hemoglobin \\> 10 g\u002FdL; platelets \\> 100000 \u002Fmm\\^3; Bilirubin \\\u003C 1.5×ULN; alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \\\u003C 2.5×ULN; creatinine \\\u003C 1.5×ULN;\n7. Peripheral blood absolute lymphocyte count must be above 0.8×10\\^9\u002FL;\n8. Satisfactory heart functions;\n9. Must be willing to follow the instructions of doctors; Women of reproductive potential (between 15 and 49 years old) must have a negative pregnancy test within 7 days of study start. Male and female patients of reproductive potential must agree to use birth control during the study and 3 months post study.\n\nExclusion Criteria:\n\n1. A prior history of gliadel implantation 4 weeks before this study start or currently receiving antibody based therapies;\n2. HIV positive;\n3. Tuberculosis infection not under control;\n4. History of autoimmune disease, or other diseases require long-term administration of steroids or immunosuppressive therapies;\n5. History of allergic disease, or allergy to immune cells or study product;\n6. Patients already actively enrolled in other immune cell clinical study; Patients, in the opinion of investigators, may not be eligible or not able to comply with the study.","ALL","2 Years","70 Years",{"count":55,"type":56},30,"ESTIMATED","INTERVENTIONAL",[59,60],"PHASE1","PHASE2","The purpose of this study is to assess the feasibility, safety and efficacy of H3K27M-specific engineered immune effector (EIE) therapy in patients with high-risk, H3K27M-positive diffuse midline glioma\u002Fdiffuse intrinsic pontine glioma. Another goal of the study is to learn more about the function of the anti-H3K27M EIE cells and their persistency in patients.",[63],"Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma",[65,66,67],"EIE","DIPG","H3K27M","2026-03-24",{"date":70,"type":71},"2026-03-30","ACTUAL",{"date":73,"type":71},"2026-03-18",{"date":75,"type":56},"2030-04-30",{"name":5,"class":6},1]