[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556071":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":36,"responsibleParty":59,"collaborators":30,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":30,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":30,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":30,"overallStatus":39,"whyStopped":30,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"First Affiliated Hospital of Fujian Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients will undergo a 68Ga-MGS5 PET\u002FCTF and 68Ga-DOTATATE PET\u002FCT","EXPERIMENTAL","MTC Patients received 68Ga-DOTATATE PET\u002FCT imaging and a single injection of 68Ga-MGS5 and two PET\u002FCT scans 1 hour and 2 hours after the injection within one week.",[13],"Drug: 68Ga-MGS5",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","68Ga-MGS5","Each patient received a single intravenous injection of 68Ga-DOTATATE (2-4 mCi) and underwent PET\u002FCT scanning 40-60 minutes after the injection. Or receive one intravenous injection of 68Ga-MGS5 and undergo two PET\u002FCT scans at 1 and 2 hours post-injection, respectively.",[9],[21],"68Ga-DOTATATE",[23],{"name":24,"affiliation":5,"role":25},"Weibing Miao","PRINCIPAL_INVESTIGATOR",[27,32],{"name":24,"role":28,"phone":29,"phoneExt":30,"email":31},"CONTACT","86-0591-87981618",null,"miaoweibing@126.com",{"name":33,"role":28,"phone":34,"phoneExt":30,"email":35},"jieling zheng","86-599-87981619","775304265@qq.com",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Department of Nuclear Medicine, First Affiliated Hospital of Fujian Medical University","RECRUITING","Fuzhou","Fujian","350005","China","CN",{"type":46,"coordinates":47},"Point",[48,49],119.30611,26.06139,{"lat":49,"lon":48},[52,55],{"name":53,"role":28,"phone":54,"phoneExt":30,"email":31},"Weibing Miao, MD","+86 591 87981618",{"name":56,"role":28,"phone":57,"phoneExt":30,"email":58},"Zhenying Chen, MB","+86 591 87981619","714144972@qq.com",{"type":25,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Weibing Miao, PhD","Director, Department of Nuclear Medicine","100556071","phase-1-head-to-head-study-of-68ga-mgs5-versus-68ga-dotatate-petct-in-patients-with-medullary-thyroid-carcinoma-100556071",false,"NCT06520319","Head-to-head Study of 68Ga-MGS5 Versus 68Ga-DOTATATE PET\u002FCT in Patients With Medullary Thyroid Carcinoma","Head-to-head Study of 68Ga-MGS5 Versus 68Ga-DOTATATE PET\u002FCT in Patients With Medullary Thyroid Carcinoma: a Prospective Study","Inclusion Criteria:\n\n* Patients of either gender, aged ≥ 18 years and ≤80 years.\n* Patients with pathologic findings confirming the diagnosis of MTC\n* Patients with MTC recurrence\n* Signed written consent\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding female patients\n* Patients with claustrophobic behavior\n* The inability or unwillingness of the research participant, parent or legal representative to provide written informed consent","ALL","18 Years","80 Years",{"count":73,"type":74},20,"ESTIMATED","INTERVENTIONAL",[77],"PHASE1","Cholecystokinin-2 (CCK2) receptor is overexpressed in more than 90% of MTC cases, and preclinical studies have shown that 68Ga-MGS5 (targeting CCK2) has good stability in vivo and is promising for diagnosis and staging of MTC. This prospective study will compare the diagnostic effects of 68Ga-MGS5 and 68Ga-DOTATATE on MTC primary foci, lymph node metastasis, and distant metastasis, and explore the effect of 68Ga-MGS5 PET\u002FCT on the clinical staging (TNM staging) of MTC.",[80],"Medullary Thyroid Carcinoma","2024-07-21",{"date":83,"type":84},"2024-07-25","ACTUAL",{"date":86,"type":84},"2023-06-21",{"date":88,"type":74},"2025-07",{"name":5,"class":6},1]