[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641893":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":47,"collaborators":19,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":19,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":19,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":78,"whyStopped":19,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"AstraZeneca","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"AZD1390","EXPERIMENTAL","Single dose of \\[14C\\]-AZD1390",[13],"Drug: AZD1390",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","single dose",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"AstraZeneca Clinical Study Information Center","CONTACT","1-877-240-9479","information.center@astrazeneca.com",[27,39],{"facility":28,"status":19,"city":29,"state":19,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":19},"Research Site","Guildford","GU2 7WG","United Kingdom","UK",{"type":34,"coordinates":35},"Point",[36,37],-0.57427,51.23536,{"lat":37,"lon":36},{"facility":28,"status":19,"city":40,"state":19,"zip":41,"country":31,"countryCode":32,"cosmosGeoPoint":42,"geoPoint":46,"contacts":19},"Liverpool","L7 8XP",{"type":34,"coordinates":43},[44,45],-2.97794,53.41058,{"lat":45,"lon":44},{"type":48,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100641893","phase-1-human-adme-study-of-14c-azd1390-100641893",false,"NCT07643870","Human ADME Study of [14C]-AZD1390","A Phase I, Open-label Study to Assess the Absorption, Distribution, Metabolism, and Excretion (ADME) of AZD1390 After a Single Oral Dose of [14C]-AZD1390 in Participants With Advanced Solid Malignancies","Inclusion Criteria:\n\n* Participants with Histologically or cytologically documented, locally advanced or metastatic solid tumour, excluding lymphoma, no active anticancer treatment,\n* ECOG performance status of 0 or 1 with no deterioration over the 2 weeks,\n* Predicted life expectancy ≥ 12 weeks,\n* Adequate organ and marrow function,\n* Creatinine clearance ≥ 50 mL\u002Fmin,\n* Regular bowel movements,\n* No cancer-associated cachexia (weight loss).\n\nExclusion Criteria:\n\n* History or presence of myopathy or raised CK \\> 5 × ULN at screening,\n* History of ILD, drug-induced ILD, radiation pneumonitis which required steroid treatment,\n* History or presence of clinically significant hepatic disease,\n* History of epileptic disorder or any seizure history unrelated to tumour,\n* History of MDS\u002FAML or with features suggestive of MDS\u002FAML,\n* Predisposition to bleeding\n* History of persisting (\\> 2 weeks) severe cytopenia\n* Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product, or previous significant bowel resection\n* History of another primary malignancy\n* Persistent toxicities (CTCAE Grade ≥ 2), excluding alopecia, caused by previous anticancer therapy,\n* Spinal cord compression or brain metastases for at least 4 weeks","ALL","18 Years","99 Years",{"count":60,"type":61},8,"ESTIMATED","INTERVENTIONAL",[64],"PHASE1","This is a Phase I, multicentre, single-dose, open-label study to assess the absorption, distribution, metabolism, and excretion of \\[14C\\]-AZD1390.",[67],"Advanced Solid Malignancies",[9,69,70,71,72,73,74,75,76,77],"Malignancies","Solid tumor","Glioblastoma","Radioactivity \u002F radiation","Metabolite \u002F metabolism","ATM kinase inhibitor","Pharmacokinetics","Single-dose","ADME","NOT_YET_RECRUITING","2026-06-10",{"date":81,"type":82},"2026-06-12","ACTUAL",{"date":84,"type":61},"2026-06-30",{"date":86,"type":61},"2028-04-12",{"name":5,"class":6},2]