[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100531759":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":92,"collaborators":94,"id":99,"slug":100,"hasResults":101,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":23,"eligibilityCriteria":104,"healthyVolunteers":101,"sex":105,"minAge":106,"maxAge":23,"enrollmentInfo":107,"targetDuration":23,"studyType":110,"phases":111,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":61,"whyStopped":23,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"Hamilton Health Sciences Corporation","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"REPAIR CKD cohort","ACTIVE_COMPARATOR","Patients will receive open label colchicine 0.3 mg daily for 8 weeks followed, in patients who tolerated the 0.3 mg dose, by forced titration to 0.6 mg daily for 8 weeks.",[13],"Drug: Colchicine",{"label":15,"type":10,"description":11,"interventionNames":16},"REPAIR Dialysis cohort",[13],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"DRUG","Colchicine","0.3mg and 0.6mg tablets",[9,15],null,[25],{"name":26,"affiliation":27,"role":28},"Michael Walsh, MD, PhD","McMaster University","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":23,"email":34},"Courtney Christou, BSc","CONTACT","905-521-2100","courtney.christou@phri.ca",{"name":36,"role":32,"phone":23,"phoneExt":23,"email":37},"Jessica Tyrwhitt, BSc","jessica.tyrwhitt@phri.ca",[39,59,77],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"University of Alberta Hospital","NOT_YET_RECRUITING","Edmonton","Alberta","T6G 2B7","Canada","CA",{"type":48,"coordinates":49},"Point",[50,51],-113.46871,53.55014,{"lat":51,"lon":50},[54,58],{"name":55,"role":32,"phone":56,"phoneExt":23,"email":57},"David Collister, MD, PhD","780-492-8618","dcollist@ualberta.ca",{"name":55,"role":28,"phone":23,"phoneExt":23,"email":23},{"facility":60,"status":61,"city":62,"state":63,"zip":64,"country":45,"countryCode":46,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"St. Joseph's Healthcare Hamilton","RECRUITING","Hamilton","Ontario","L8N 4A6",{"type":48,"coordinates":66},[67,68],-79.84963,43.25011,{"lat":68,"lon":67},[71,76],{"name":72,"role":32,"phone":73,"phoneExt":74,"email":75},"Lonnie Pyne, MD, PhD","905-522-1155","32299","lpyne@stjoes.ca",{"name":72,"role":28,"phone":23,"phoneExt":23,"email":23},{"facility":78,"status":41,"city":79,"state":63,"zip":80,"country":45,"countryCode":46,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"London Health Sciences Centre","London","N6A 5A5",{"type":48,"coordinates":82},[83,84],-81.23304,42.98339,{"lat":84,"lon":83},[87,91],{"name":88,"role":32,"phone":89,"phoneExt":23,"email":90},"Pavel Roshanov, MD, PhD","519-685-8500","pavel.roshanov@lhsc.on.ca",{"name":88,"role":28,"phone":23,"phoneExt":23,"email":23},{"type":93,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[95,97],{"name":96,"class":6},"Hamilton Academic Health Sciences Organization",{"name":98,"class":6},"St. Joseph's Health Care London","100531759","phase-1-inflammation-reduction-to-prevent-cardiovascular-injury-in-renal-disease-repair-100531759",false,"NCT06203977","Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR)","Inclusion Criteria:\n\n1. One of either:\n\n   1.2 Estimated GFR using CKD-EPI 2021 equation of ≤30 ml\u002Fmin\u002F1.73m2 on at least two occasions separated by at least 2 months and do not yet require dialysis and are not expected by their treating nephrologist to require dialysis in the next 6 months (REPAIR CKD cohort), or 1.3 receiving chronic maintenance dialysis 2 or more times per week for the previous 90 days (REPAIR Dialysis cohort);\n2. Age ≥18 years\n3. Provide informed consent to participate.\n\nExclusion Criteria:\n\n1. Currently treated with and cannot withdraw colchicine due to medical necessity; or\n2. Known allergy\u002Fsensitivity to colchicine; or\n3. Prior self-reported intolerance to colchicine at a dose of 0.6 mg daily or lower; or\n4. Currently pregnant or planning to become pregnant or breastfeed during the study; or\n5. Of childbearing potential AND do not have a negative pregnancy test OR do not agree to use two forms of contraception for the duration of the study; or\n6. Anticipated living donor renal transplant within the next 6 months; or\n7. Using a strong inhibitor of p-glycoprotein or strong inhibitor of CYP3A4 in the last 14 days; or\n8. B12 deficiency not managed with intramuscular supplementation; or\n9. Uncontrolled chronic diarrhea; or\n10. Cirrhosis, or chronic active hepatitis; or\n11. Pre-existent neuromuscular disease or persistent serum CK level \\> 3 times the upper limit of normal as measured within the past 60 days and determined to be non-transient through repeat testing; or\n12. Patient with any of the following within the past 60 days:\n\n    * white blood cell count \\\u003C 3.0 X 109\u002FL; or\n    * platelet count \\\u003C110 X 109\u002FL; or\n    * ALT or AST \\> 3 times the upper limit of normal (ULN); or\n    * total bilirubin \\> 2 times ULN and not due to Gilbert syndrome.\n13. Patient is considered by the investigator, for any reason, to be an unsuitable candidate for the study.","ALL","18 Years",{"count":108,"type":109},200,"ESTIMATED","INTERVENTIONAL",[112],"PHASE1","Phase 1 basket trial including 2 open-label single-arm cohorts: REPAIR CKD cohort and REPAIR Dialysis cohort. Open label colchicine 0.3 mg daily for 8 weeks followed, in patients who tolerated the 0.3 mg dose, by forced titration to 0.6 mg daily for 8 weeks.",[115,116],"Chronic Kidney Diseases","Renal Failure",[118,119,120],"Tolerance","Colchicine Resistance","Hematologic markers","2025-03-10",{"date":123,"type":124},"2025-03-12","ACTUAL",{"date":126,"type":124},"2024-11-15",{"date":128,"type":109},"2026-05-31",{"name":5,"class":6},3]