[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564569":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":42,"responsibleParty":57,"collaborators":59,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":26,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Polysaccharide typhoid vaccine","EXPERIMENTAL","Participants in this condition will receive an injection of 0.5ml Salmonella typhi capsular polysaccharide vaccine (Sanofi Pasteur, SA), which contains 25μg of purified Vi polysaccharide in a colorless isotonic phosphate buffered saline (pH 7±0.3), 4.150mg of sodium chloride, 0.065mg of disodium phosphate, 0.023mg of monosodium phosphate and 0.5ml of sterile water for injection.",[13],"Biological: Typhoid VI Polysaccharide Vaccine Injectable Solution",{"label":15,"type":16,"description":17,"interventionNames":18},"Saline Placebo Arm","PLACEBO_COMPARATOR","Participants in this condition will receive and injection of 0.5ml of saline.",[19],"Other: Saline Placebo (0.5mL injection)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","Typhoid VI Polysaccharide Vaccine Injectable Solution","Salmonella typhi capsular polysaccharide vaccine (Typhoid Vi Polysaccharide Vaccine): Each dose of 0.5ml Salmonella typhi capsular polysaccharide vaccine (Sanofi Pasteur, SA) is formulated to contain 25μg of purified Vi polysaccharide in a colorless isotonic phosphate buffered saline (pH 7±0.3), 4.150mg of sodium chloride, 0.065mg of disodium phosphate, 0.023mg of monosodium phosphate and 0.5ml of sterile water for injection. It is indicated for use by humans aged 2 years and older for protection against typhoid fever.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Saline Placebo (0.5mL injection)","The placebo injection will consist of 0.5mL of saline.",[15],[32],{"name":33,"affiliation":5,"role":34},"Aoife O'Donovan, PhD","PRINCIPAL_INVESTIGATOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","415-221-4810","aoife.odonovan@ucsf.edu",{"name":41,"role":37,"phone":38,"phoneExt":26,"email":26},"Michael Srouji, BA",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":26},"San Francisco VA Health Care System","RECRUITING","San Francisco","California","94121","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-122.41942,37.77493,{"lat":55,"lon":54},{"type":58,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[60,63,65],{"name":61,"class":62},"National Institute of Mental Health (NIMH)","NIH",{"name":64,"class":6},"Northern California Institute of Research and Education",{"name":66,"class":67},"San Francisco Veterans Affairs Medical Center","FED","100564569","phase-1-inflammatory-challenge-and-fear-100564569",false,"NCT06630884","Inflammatory Challenge and Fear","Inflammatory Challenge and Fear Extinction: A Model to Enhance Understanding of Posttraumatic Stress Disorder","LIFE","Inclusion Criteria:\n\nAll Subjects:\n\n1. Aged 18-60 years old\n2. Trauma Exposed\n3. Current PTSD\u002FNo history of PTSD\n\nExclusion Criteria:\n\n1. Contraindications to typhoid vaccine\n2. Conditions associated with inflammation\n3. Pregnancy or plans to become pregnant in next three months",true,"ALL","18 Years","60 Years",{"count":81,"type":82},288,"ESTIMATED","INTERVENTIONAL",[85],"PHASE1","The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are:\n\nDo people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel?\n\nParticipants will:\n\nAttend four appointments at the San Francisco VA Health Care System;\n\nReceive typhoid vaccine or placebo at one of the visits;\n\nHave their physiological responding measured while listening to sounds;\n\nComplete questionnaires and psychological tests.",[88],"Posttraumatic Stress Disorder (PTSD)",[90,91,92,93],"PTSD","posttraumatic stress","inflammation","fear","2025-12-10",{"date":96,"type":97},"2025-12-15","ACTUAL",{"date":99,"type":97},"2025-03-28",{"date":101,"type":82},"2028-11",{"name":5,"class":6},1]