[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639799":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":29,"collaborators":11,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":11,"eligibilityCriteria":37,"healthyVolunteers":38,"sex":39,"minAge":40,"maxAge":11,"enrollmentInfo":41,"targetDuration":11,"studyType":44,"phases":45,"briefSummary":48,"conditions":49,"keywords":54,"overallStatus":62,"whyStopped":11,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":11},{"fullName":5,"class":6},"Vrije Universiteit Brussel","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active tACS","ACTIVE_COMPARATOR",null,[13],"Device: Transcranial alternating current stimulation (tACS)",{"label":15,"type":16,"description":11,"interventionNames":17},"Sham tACS","SHAM_COMPARATOR",[18],"Device: Sham treatment",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DEVICE","Transcranial alternating current stimulation (tACS)","Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that uses electrodes on the scalp to apply weak alternating electrical currents to the brain.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Sham treatment","mimics active tACS but stops after 1 minute",[15],{"type":30,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100639799","phase-1-investigating-central-contributions-to-fatigue-using-non-invasive-brain-stimulation-100639799",false,"NCT07613970","Investigating Central Contributions to Fatigue Using Non-invasive Brain Stimulation","Investigating the Causal Contribution of Neural Oscillations to Neuromuscular Fatigue After Stroke Using tACS","Inclusion Criteria:\n\nFirst-ever stroke\n\n≥18 years Subacute phase: 1 week to 6 months post-stroke Quadriceps (hemiplegic side) strength ≤3\u002F5 (Medical Research Council (MRC)) Montreal Cognitive Assessment (MoCA) ≥21\n\nExclusion Criteria:\n\nHistory of a previous stroke Severe spasticity (Modified Ashworth Scale (MAS) 3-4 in quadriceps\u002Fhamstrings) Other neurological, motor, musculoskeletal, or orthopedic conditions affecting trunk stability and lower limb mobility Non-cerebral strokes (e.g., brainstem, cerebellar), or dementia (MoCA ≤20) Current or former athletes. Athletes are defined as individuals who participated in organized competitive sports and engaged in structured training ≥3 sessions per week for ≥1 year within the 5 years preceding stroke Contraindications for tACS (e.g., presence of a deep brain stimulator, pacemaker, head wound, etc.).",true,"ALL","18 Years",{"count":42,"type":43},120,"ESTIMATED","INTERVENTIONAL",[46,47],"PHASE1","PHASE2","The goal of this interventional study is to understand the contribution of the central components to the manifestation of neuromuscular fatigue in stroke survivors. The study will include adults with a first-ever stroke in the subacute phase.\n\nThe main question it aims to answer:\n\n• How does the brain activity contribute to the manifestation of neuromuscular fatigue in stroke survivors?\n\nResearchers will compare stroke participants receiving active vs sham tACS in a single session before the fatiguing contractions to determine whether central changes can influence fatigue onset\u002Fprogression.\n\nParticipants will:\n\n* Perform repeated leg muscle contractions until fatigue while seated in an experimental setup\n* Receive either active or sham tACS for 20 minutes before the fatiguing contractions.\n* Wear non-invasive sensors to record brain activity (EEG) and muscle activity (EMG) during the task\n* Complete the study during a single experimental session in which fatigue-related changes will be measured throughout the task",[50,51,52,53],"Stroke","Cerebrovascular Accident (CVA)","Ischemia Stroke","Hemorrhage Stroke",[55,56,57,58,59,60,61],"fatigue","electroencephalography","EEG","electromyography","EMG","transcranial alternating current stimulation","tACS","NOT_YET_RECRUITING","2026-05-21",{"date":65,"type":66},"2026-05-29","ACTUAL",{"date":68,"type":43},"2026-09-01",{"date":70,"type":43},"2029-10-31",{"name":5,"class":6}]