[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553393":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":31,"locations":41,"responsibleParty":61,"collaborators":31,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":31,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":31,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":31,"overallStatus":44,"whyStopped":31,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Zagazig University","OTHER_GOV",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Itraconazole","ACTIVE_COMPARATOR","all patients will be prescribed Itraconazole in the dose of 200mg twice daily for 1 week per month, for 3 consecutive months after screening of complete blood count, liver, and renal function tests. patients were advised to record any side effects",[13],"Drug: Itraconazole 200 mg",{"label":15,"type":16,"description":17,"interventionNames":18},"Itraconazole + Low dose Isotretinoin","EXPERIMENTAL","patients will be given low dose of isotretinoin as an adjuvant to itraconazole in the same previously mentioned protocol. Treatment protocol consists of low dose isotretinoin (20mg, every other day for pediatrics) for a 3- month course. After completion of the course, treating dose of isotretinoin was maintained for 4-6 weeks to prevent recurrence, and to improve healing. During treatment, an infrequent application of the previous therapies was permitted.",[19],"Drug: ISOtretinoin 10 MG",{"label":21,"type":16,"description":22,"interventionNames":23},"Itraconazole +Excimer light","will be treated with excimer light as an adjuvant to itraconazole in the same previously mentioned protocol. Nails will be treated with XeCl2 excimer light (Eximal Elite Device).",[24],"Device: excimer light",[26,32,37],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","ISOtretinoin 10 MG","Low dose isotretinoin as an adjuvant for itraconazole in treating onychomycosis",[15],null,{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":31},"DEVICE","excimer light","excimer light as an adjuvant for itraconazole in treating onychomycosis",[21],{"type":27,"name":38,"description":39,"armGroupLabels":40,"otherNames":31},"Itraconazole 200 mg","Itraconazole alone",[9],[42],{"facility":43,"status":44,"city":45,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Zagazig University Hospitals","RECRUITING","Zagazig","44519","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],31.502,30.58768,{"lat":53,"lon":52},[56],{"name":57,"role":58,"phone":59,"phoneExt":31,"email":60},"mona Elradi, MD","CONTACT","+201067070550","monaelradi@medicine.zu.edu.eg",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Mona El Radi Kamal Mohamed Emam","Principle Investigator","100553393","phase-1-isotretinoin-versus-excimer-light-an-adjuvant-in-treating-onychomycosis-100553393",false,"NCT06485505","Isotretinoin Versus Excimer Light an Adjuvant in Treating Onychomycosis","Efficacy of Low Dose Isotretinoin Versus Excimer Light as an Adjuvant for Itraconazole in Treatment of Onychomycosis: a Randomized Controlled Trial.","Inclusion Criteria:\n\n* patients with onychomycosis\n\nExclusion Criteria:\n\n* pregnant and lactating females patients on statin therapy or photosensitizing drugs patients with liver disease, heart disease and diabetes milletus.","ALL","18 Years","60 Years",{"count":76,"type":77},36,"ESTIMATED","INTERVENTIONAL",[80],"PHASE1","3 groups of patients with onychomycosis will be recruited. Group A will receive itraconazole alone. Group B will receive itraconazole + low dose isotretinoin and group C will be treated with itraconazole + excimer light sessions.",[83],"Onychomycosis","2026-04-19",{"date":86,"type":87},"2026-04-23","ACTUAL",{"date":89,"type":87},"2024-07-12",{"date":91,"type":77},"2026-12",{"name":5,"class":6},1]