[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629491":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":26,"responsibleParty":32,"collaborators":26,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":26,"studyType":49,"phases":50,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":59,"whyStopped":26,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":26},{"fullName":5,"class":6},"University of Faisalabad","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"LSTR therapy","EXPERIMENTAL","Participants in this group receive CTZ antibiotic paste placed in the pulp chamber after irrigation.",[13],"Drug: Group A - LSTR Therapy (CTZ Paste)",{"label":15,"type":16,"description":17,"interventionNames":18},"Zinc Oxide Eugenol (ZOE) Pulpectomy","ACTIVE_COMPARATOR","Participants in this group receive conventional pulpectomy with ZOE paste placed in the root canals.",[19],"Procedure: Group B - ZOE Pulpectomy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Group A - LSTR Therapy (CTZ Paste)","Placement of CTZ antibiotic paste (chloramphenicol, tetracycline, zinc oxide mixed with eugenol) in the pulp chamber after irrigation with 3% sodium hypochlorite, followed by restoration with resin-modified glass ionomer cement.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","Group B - ZOE Pulpectomy","Intervention: Conventional pulpectomy including working length determination, canal debridement with K-files and 3% sodium hypochlorite irrigation, followed by obturation with zinc oxide eugenol paste and final restoration with resin-modified glass ionomer cement.",[15],{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Hira Zaman","Assistant Professor","100629491","phase-1-lesion-sterilization-and-tissue-repair-antibiotic-paste-versus-zinc-oxide-and-eugenol-pulpectomy-for-treatment-of-primary-molars-with-pulp-necrosis-100629491",false,"NCT07475364","Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis","LSTR","Inclusion Criteria:\n\n* • Children of both genders\n\n  * 4 years and 10 years\n  * Pulp necrosis in mandibular primary molars with minimum of 2\u002F3 of the roots\n  * Consent from Parents\u002FGuardian of children.\n  * Sufficient crown structure for restoration\n\nExclusion Criteria:\n\n* • Children who have a physical or mental change.\n\n  * Involving systemic illnesses.\n  * History of allergy to drugs being utilized\n  * Antibiotics use within three months\n  * Teeth with aberrant root resorption or pulp canal obliteration on periapical radiography","ALL","4 Years","10 Years",{"count":47,"type":48},180,"ESTIMATED","INTERVENTIONAL",[51,52],"PHASE1","PHASE2","The goal of this clinical trial is to compare the efficacy of lesion sterilization and tissue repair (LSTR) antibiotic paste versus zinc oxide eugenol (ZOE) pulpectomy for the treatment of primary molars with pulp necrosis in pediatric patients.\n\nThe main questions it aims to answer are:\n\n* Is LSTR antibiotic paste (CTZ paste) effective in treating primary molars with pulp necrosis?\n* Is ZOE pulpectomy effective in treating primary molars with pulp necrosis, and how does its efficacy compare with LSTR therapy?\n\nResearchers will compare LSTR therapy (Group A) with ZOE pulpectomy (Group B) to determine which treatment provides better clinical and radiographic outcomes after six months.\n\nParticipants will:\n\n* Be randomly assigned to one of the two treatment groups after diagnosis of pulp necrosis in primary molars.\n* Receive treatment under standard behavior management techniques with local anesthesia following topical application of 2% lignocaine gel and rubber dam isolation.\n* Undergo either Lesion Sterilization and Tissue Repair (LSTR) therapy with CTZ paste or zinc oxide eugenol (ZOE) pulpectomy according to group allocation.\n* Return for a clinical and radiographic follow-up evaluation after six months to assess treatment outcomes.\n* Allow researchers to record their clinical findings and radiographic results to evaluate the efficacy of both treatment methods.",[55],"Pulp Necrosis",[9,57,58],"primary molars","pulp therapy","NOT_YET_RECRUITING","2026-03-16",{"date":62,"type":63},"2026-03-19","ACTUAL",{"date":65,"type":48},"2026-05-01",{"date":67,"type":48},"2027-05-01",{"name":5,"class":6}]