[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557865":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":49,"collaborators":20,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":20,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Iran University of Medical Sciences","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Limbal Stem Cell Derived Exosome Eye Drop treatment","EXPERIMENTAL","Patients will receive artificial tears for 2 weeks to get the normalized baseline, followed by LSC-Exo eye drop intervention for 3 months.",[13],"Biological: Limbal Stem Cell Derived Exosomes Eye Drop",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BIOLOGICAL","Limbal Stem Cell Derived Exosomes Eye Drop","Patients will receive artificial tears for 2 weeks to get the normalized baseline, followed by LSC-Exo eye drops 0.15 ml\u002Fsingle eye\u002Fone time, four times a day for 3 months. The follow-up visit will be 12 weeks since the administration of LSC-Exo eye drops.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Hossein Aghaei, MD","CONTACT","+982155661188","draghaei.h@gmail.com",{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},"Alireza Shoae-Hassani","+989121454878","cell.therapy@yahoo.com",[32],{"facility":33,"status":34,"city":35,"state":20,"zip":20,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Moheb Kowsar Hospital","RECRUITING","Tehran","Iran","IR",{"type":39,"coordinates":40},"Point",[41,42],51.42151,35.69439,{"lat":42,"lon":41},[45],{"name":46,"role":24,"phone":47,"phoneExt":20,"email":48},"Kian Alirezaei, MD","+989034561467","Kian.alirezaei.72@gmail.com",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Alireza Shoae Hassani","Director","100557865","phase-1-limbal-stem-cell-derived-exosome-lsc-exo-eye-drop-for-treatment-of-dry-eye-100557865",false,"NCT06543667","Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye","A Clinical Study for Safety and Efficacy Evaluation of Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye Syndrome","EXOIUMS","Inclusion Criteria:\n\n* Patients with complaints of burning or itching or feeling of a foreign body in the eye\n* Moderate and severe dry eye severity\n* Age between 18-70 years\n\nExclusion Criteria:\n\n* Previous history of eye surgery\n* Any disease that suppresses the immune system\n* Pregnancy and breastfeeding\n* Eyelid abnormalities\n* Use of eye drops in the past year except artificial tears and lubricating ointments\n* Use of systemic drugs that affect the tear film in last three months\n* Use of contact lenses in the last three months","ALL","18 Years","70 Years",{"count":65,"type":66},30,"ESTIMATED","INTERVENTIONAL",[69],"PHASE1","The purpose of this study is to determine the safety and efficacy of Limbal Stem Cells derived Exosomes (LSC-Exo) in alleviation of dry eye symptoms",[72],"Dry Eye Syndromes",[74,75,76],"Dry Eye Disease","Sjogren's Syndrome","Chronic Dry Eye","2025-04-30",{"date":79,"type":80},"2025-05-01","ACTUAL",{"date":82,"type":80},"2024-08-01",{"date":84,"type":66},"2026-07-01",{"name":5,"class":6},1]