[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100485768":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":35,"locations":31,"responsibleParty":44,"collaborators":31,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":31,"enrollmentInfo":57,"targetDuration":31,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":72,"overallStatus":77,"whyStopped":31,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":31},{"fullName":5,"class":6},"University of Cincinnati","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment arm (1)","EXPERIMENTAL","This arm will receive 200mg of minocycline in a single capsule per day.",[13],"Drug: Minocycline",{"label":15,"type":16,"description":17,"interventionNames":18},"Treatment arm (2)","ACTIVE_COMPARATOR","This arm will receive 300 mg of minocycline in a single capsule per day. This capsule is identical in size and appearance as the 200 mg capsule",[13],{"label":20,"type":21,"description":22,"interventionNames":23},"Placebo","PLACEBO_COMPARATOR","This arm will receive the placebo which is similar in size and appearance as the 200 mg and 300 mg capsules.",[24],"Drug: Placebo",[26,32],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Minocycline","Minocycline is a second-generation tetracycline antibiotic with good central nervous system penetration and anti-neuroinflammatory effect.",[9,15],null,{"type":27,"name":20,"description":33,"armGroupLabels":34,"otherNames":31},"This is capsule that is identical in size and appearance as the drug, but without active drug ingredient.",[20],[36,41],{"name":37,"role":38,"phone":39,"phoneExt":31,"email":40},"Christian Mpulumba, MD","CONTACT","513-558-2115","mpulumcm@ucmail.uc.edu",{"name":42,"role":38,"phone":31,"phoneExt":31,"email":43},"Kristine A Karkoska, MD","karkoska@ucmail.uc.edu",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Kristine Karkoska","Assistant Professor","100485768","phase-1-minocycline-in-neurocognitive-outcomes---sickle-cell-disease-100485768",false,"NCT05605366","Minocycline In Neurocognitive Outcomes - Sickle Cell Disease","MINO-SCD","Inclusion Criteria:\n\nAdults (age ≥ 18 years old) with SCD (HbSS and HbS-β0thalassemia genotypes only) who are followed at the University of Cincinnati Medical Center's SCD clinic are eligible to participate. As hydroxyurea is the standard-of-care in SCD, individuals on hydroxyurea will be included\n\nExclusion Criteria:\n\n1. adults with other SCD genotypes (HbSC or HbS- β+thalassemia),\n2. individuals with a history of overt stroke or other known neurological disorder,\n3. premature birth before 30 weeks gestation,\n4. monthly therapy with chronic blood transfusions,\n5. coexisting autoimmune condition due to an elevated risk for autoimmune-related complications with tetracyclines,\n6. tetracycline allergy.\n7. Women who are pregnant or breast-feeding","ALL","18 Years",{"count":58,"type":59},30,"ESTIMATED","INTERVENTIONAL",[62],"PHASE1","Sickle cell disease (SCD) is a common, inherited blood disorder that primarily affects people of African Ancestry. It has a lot of complications including neurological complications. The neurological complications of SCD are particularly devastating and lead to cognitive decline even in the absence of overt brain injury. In such cases, it is thought that inflammation in the brain maybe partly responsible for the cognitive decline.\n\nThe main reasons for this research study are to see 1) how safe and 2) how well minocycline works to try to stop\u002Freverse cognitive decline in people with SCD. People with SCD are at risk for changes in their brain over time that can cause problems with learning, memory, and attention. Part of the reason for this is inflammation within the brain. Minocycline may be able to stop these brain changes by stopping this brain inflammation.\n\nMinocycline is a second-generation tetracycline antibiotic that has been shown to both inhibit neuroinflammation and improve cognitive function in a variety of neurodegenerative and psychiatric disorders but has not yet been studied in SCD. We are proposing here, a pilot double-blinded, randomized controlled trial to examine the tolerability and early efficacy of minocycline in adults with SCD at two dosing regimens (200 mg and 300 mg daily) versus placebo over one year. Participants will undergo a neuropsychological exam using the NIH Toolbox Cognition Battery at both study enrollment and exit (after one year) to assess for changes\u002Fstability of cognition. Participants will receive monthly phone calls\u002Ftext messages to assess for adverse events and will be seen every three months for pill counts and routine laboratory monitoring. The primary outcome will be a comparison of adverse events across the two dosing strategies versus placebo. Early evidence for cognitive benefit will also be assessed from the results of the NIH Toolbox.",[65,66,67,68,69,70,71],"Sickle Cell Disease","Cognitive Impairment","Cognitive Decline","Cognitive Change","Cognitive Dysfunction","Cognitive Deficit","Neuroinflammatory Response",[73,74,75,76],"sickle cell disease","benign hematology","cognitive dysfunction","neuroinflammation","NOT_YET_RECRUITING","2026-05-11",{"date":80,"type":81},"2026-05-14","ACTUAL",{"date":83,"type":59},"2026-12-01",{"date":85,"type":59},"2028-06-15",{"name":5,"class":6}]