[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601736":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":19,"locations":20,"responsibleParty":97,"collaborators":19,"id":99,"slug":100,"hasResults":101,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":101,"sex":107,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":19,"studyType":113,"phases":114,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":23,"whyStopped":19,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"NOBO Medicine","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"NB02 (Poseltinib)","EXPERIMENTAL","Dose Level 1 Dose Level 2 Dose Level 3",[13],"Drug: NB02 (Poseltinib)",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Dose Level 1, Dose Level 2, Dose Level 3",[9],null,[21,38,51,64,74,84],{"facility":22,"status":23,"city":24,"state":19,"zip":19,"country":25,"countryCode":19,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Chonnam National University Hwasun Hospital","RECRUITING","Hwasun","South Korea",{"type":27,"coordinates":28},"Point",[29,30],126.98746,35.06125,{"lat":30,"lon":29},[33],{"name":34,"role":35,"phone":36,"phoneExt":19,"email":37},"Deok-Hwan Yang","CONTACT","82-61-379-7636","drydh1685@hotmail.com",{"facility":39,"status":23,"city":40,"state":19,"zip":19,"country":25,"countryCode":19,"cosmosGeoPoint":41,"geoPoint":45,"contacts":46},"Seoul National University Bundang Hospital","Seongnam",{"type":27,"coordinates":42},[43,44],127.7548,36.4052,{"lat":44,"lon":43},[47],{"name":48,"role":35,"phone":49,"phoneExt":19,"email":50},"Jeong-Ok Lee","82-31-787-7055","deafkeller@snubh.org",{"facility":52,"status":23,"city":53,"state":19,"zip":19,"country":25,"countryCode":19,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Catholic univ of Yeouido St Mary's Hospital","Seoul",{"type":27,"coordinates":55},[56,57],126.9784,37.566,{"lat":57,"lon":56},[60],{"name":61,"role":35,"phone":62,"phoneExt":19,"email":63},"Young Woo Jeon","82-2-3779-1049","native47@catholic.ac.kr",{"facility":65,"status":23,"city":53,"state":19,"zip":19,"country":25,"countryCode":19,"cosmosGeoPoint":66,"geoPoint":68,"contacts":69},"Samsung Medical Center",{"type":27,"coordinates":67},[56,57],{"lat":57,"lon":56},[70],{"name":71,"role":35,"phone":72,"phoneExt":19,"email":73},"Won Seog Kim","82-2-2148-7390","wonseog.kim@samsung.com",{"facility":75,"status":23,"city":53,"state":19,"zip":19,"country":25,"countryCode":19,"cosmosGeoPoint":76,"geoPoint":78,"contacts":79},"Seoul National University Hospital",{"type":27,"coordinates":77},[56,57],{"lat":57,"lon":56},[80],{"name":81,"role":35,"phone":82,"phoneExt":19,"email":83},"Jamin Byun","82-2-2072-4850","jaminbyun@snu.ac.kr",{"facility":85,"status":23,"city":86,"state":19,"zip":19,"country":25,"countryCode":19,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Ulsan University Hospital","Ulsan",{"type":27,"coordinates":88},[89,90],129.31667,35.53722,{"lat":90,"lon":89},[93],{"name":94,"role":35,"phone":95,"phoneExt":19,"email":96},"Jae Cheol Jo","82-52-250-7048","jcjo@uuh.ulsan.kr",{"type":98,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100601736","phase-1-nb02poseltinib-monotherapy-in-rr-non-hodgkins-lymphoma-100601736",false,"NCT07114367","NB02(POSELTINIB) Monotherapy in R\u002FR Non-Hodgkin's Lymphoma","An Open-Label, Multicenter, Monotherapy, Dose-Escalation, Phase 1 Clinical Trial of NB02 (Posseltinib) in Patients With Relapsed\u002FRefractory Non-Hodgkin's Lymphoma","POTENTIAL-M","Inclusion Criteria:\n\n1. Age 19 to 80 years.\n2. Patients must voluntarily agree to participate in the study and provide written informed consent prior to any study-related procedures.\n3. Patients with histologically confirmed follicular lymphoma, mantle cell lymphoma or marginal zone lymphoma.\n4. relapsed\u002Frefractory Patients who have received more than two prior lines of therapy.\n5. Measurable disease based on Lugano classification.\n6. Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2.\n7. Adequate organ function including:\n\nExclusion Criteria:\n\n1. Previous treatment with NB02 (poseltinib).\n2. Patients who have experienced progression on BTKi mono or BTKi containing regimen (However, patients who discontinued treatment due to adverse-effect-related intolerance or for economic or social reasons remain eligible for enrollment).\n3. Unable to take oral medication.\n4. Inability to comply with study and follow-up procedures.\n5. Concurrent use of other investigational drugs or enrollment in another clinical trial within 4 weeks prior to study drug administration.\n6. Patients who have previously been treated with NB02 (poseltinib) or any other BTK inhibitors (e.g., ibrutinib, acalabrutinib, zanubrutinib).\n7. Known HIV, HCV and HBV infection with active diseases","ALL","19 Years","80 Years",{"count":111,"type":112},9,"ESTIMATED","INTERVENTIONAL",[115],"PHASE1","This trial is an open-label, multicenter, monotherapy, dose-escalation, phase 1 clinical trial to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary anti-tumor activity of NB02 (posseltinib) in patients with relapsed\u002Frefractory NHL including FL, MCL and MZL",[118],"Non Hodgkin Lymphoma (NHL)",[120,121,122,123,124,125,126],"Relapsed","Refractory","Lymphoma","NHL","FL","MCL","MZL","2026-01-28",{"date":129,"type":130},"2026-01-30","ACTUAL",{"date":132,"type":130},"2025-12-02",{"date":134,"type":112},"2027-12-31",{"name":5,"class":6},6]