[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504731":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":42,"centralContacts":47,"locations":59,"responsibleParty":79,"collaborators":41,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":41,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":41,"studyType":96,"phases":97,"briefSummary":100,"conditions":101,"keywords":105,"overallStatus":62,"whyStopped":41,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Hospital Infantil de Mexico Federico Gomez","OTHER",[8,16,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Natural water","PLACEBO_COMPARATOR","250 ml of natural water should be drunk\n\n* Salivary pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Dental biofilm pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Streptococcus mutans and Streptoccus sobrinus proliferation in dental biofilm ( PCR copies) will be analyzed at 0 and 120 minutes later\n* The relative abundance of Streptococcus mutans and Streptococcus sobrinus in dental biofilm will be analyzed using Amplicon Sequence Variant at 0 and 120 minutes later",[13,14,15],"Drug: Stevioside","Drug: Sucrose","Other: Natural water",{"label":17,"type":18,"description":19,"interventionNames":20},"Stevioside","EXPERIMENTAL","250 ml of natural water added with 0.1 grams of stevioside should be drunk\n\n* Salivary pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Dental biofilm pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Streptococcus mutans and Streptoccus sobrinus proliferation in dental biofilm ( PCR copies) will be analyzed at 0 and 120 minutes later\n* The relative abundance of Streptococcus mutans and Streptococcus sobrinus in dental biofilm will be analyzed using Amplicon Sequence Variant at 0 and 120 minutes later",[13,14,15],{"label":22,"type":23,"description":24,"interventionNames":25},"Sucrose","ACTIVE_COMPARATOR","250 ml of natural water added with 25 of sucrose grams with should be drunk.\n\n* Salivary pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Dental biofilm pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Streptococcus mutans and Streptoccus sobrinus proliferation in dental biofilm ( PCR copies) will be analyzed at 0 and 120 minutes later\n* The relative abundance of Streptococcus mutans and Streptococcus sobrinus in dental biofilm will be analyzed using Amplicon Sequence Variant at 0 and 120 minutes later",[13,14,15],[27,33,38],{"type":28,"name":17,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","250 ml of natural water added with 0.1 gr. of stevioside should be drunk\n\n* Salivary pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Dental biofilm pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Streptococcus mutans and Strepcotoccus sobrinus proliferation in dental biofilm ( PCR copies) will be analyzed at 0 and 120 minutes later\n* The relative abundance of Streptococcus mutans and Streptococcus sobrinus in dental biofilm will be analyzed using Amplicon Sequence Variant at 0 and 120 minutes later",[9,17,22],[32],"Non caloric sweetener",{"type":28,"name":22,"description":34,"armGroupLabels":35,"otherNames":36},"250 ml of natural water added with 25 gr of sucrose should be drunk\n\n* Salivary pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Dental biofilm pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Streptococcus mutans and Strepcotoccus sobrinus proliferation in dental biofilm ( PCR copies) will be analyzed at 0 and 120 minutes later\n* The relative abundance of Streptococcus mutans and Streptococcus sobrinus in dental biofilm will be analyzed using Amplicon Sequence Variant at 0 and 120 minutes later",[9,17,22],[37],"Caloric sweetener",{"type":6,"name":9,"description":39,"armGroupLabels":40,"otherNames":41},"250 ml of natural water should be drunk\n\n* Salivary pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Dental biofilm pH will be analyzed at 0,5,10,15,30,45 and 60 minutes later\n* Streptococcus mutans and Strepcotoccus sobrinus proliferation in dental biofilm ( PCR copies) will be analyzed at 0 and 120 minutes later\n* The relative abundance of Streptococcus mutans and Streptococcus sobrinus in dental biofilm will be analyzed using Amplicon Sequence Variant at 0 and 120 minutes later",[9,17,22],null,[43],{"name":44,"affiliation":45,"role":46},"Carolina Barajas, MsC","Children´s Hospital Federico Gómez. México","PRINCIPAL_INVESTIGATOR",[48,54],{"name":49,"role":50,"phone":51,"phoneExt":52,"email":53},"América L Miranda, PhD","CONTACT","5552289917","4304","americaml@hotmail.com",{"name":55,"role":50,"phone":56,"phoneExt":57,"email":58},"Guadalupe C Barajas, MsC","5536596998","4600","barajascaro@hotmail.com",[60],{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"Hospital Infantil de México Federico Gomez","RECRUITING","Mexico City","Cuahutemoc","06720","Mexico","MX",{"type":69,"coordinates":70},"Point",[71,72],-99.12766,19.42847,{"lat":72,"lon":71},[75,77],{"name":44,"role":50,"phone":76,"phoneExt":57,"email":58},"55 52 28 9917",{"name":44,"role":50,"phone":78,"phoneExt":57,"email":58},"55 52 28 99 17",{"type":46,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"Guadalupe Barajas","Principal Investigator","100504731","phase-1-oral-changes-with-caloric-and-no-caloric-sweeteners-100504731",false,"NCT05852145","Oral Changes With Caloric and no Caloric Sweeteners","Effect of the Consumption of Beverages Added With Stevia Rebaudiana on Oral pH and Dental Biofilm in Adolescents","Inclusion Criteria:\n\n* Habitual consumption of soft drinks\n* Decayed, Missing, and Filled Teeth (DMF) index of at least 3 (considering as caries those lesions that are visible without the tooth needing to be dry)\n* Agree to participate in the study and sign informed consent\n* Parents sign informed consent\n* Any nutritional condition\n\nExclusion Criteria:\n\n* Orthodontic treatment\n* Topical application of fluoride during the last 3 months\n* Having a motor disability that interfered with tooth brushing\n* Xerostomia\n* Antibiotic therapy during the study period\n* Periodontal infections",true,"ALL","12 Years","18 Years",{"count":94,"type":95},52,"ESTIMATED","INTERVENTIONAL",[98,99],"PHASE1","PHASE2","The objective of this clinical trial is to compare the effect that the intake of beverages without sweeteners, added with non-caloric sweeteners (stevioside) and caloric sweeteners (sucrose) on oral pH and dental biofilm microbiome in Mexican adolescents.\n\nParticipants will drink on different occasions a beverage without sweetener, a beverage added with stevioside or a beverage added with sucrose. The researchers will compare the changes that each one causes in salivary pH, dental biofilm pH, dental biofilm bacterial proliferation and dental biofilm microbiome.",[102,103,104],"pH","Microbiome","Dental Plaque",[106,107,102,108,109,110],"artificial sweetener","stevioside","caries","sucrose","dental biofilm","2025-10-07",{"date":113,"type":114},"2025-10-09","ACTUAL",{"date":116,"type":114},"2025-08-01",{"date":118,"type":95},"2026-04",{"name":5,"class":6},1]