[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505547":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":31,"responsibleParty":46,"collaborators":24,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":24,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":24,"studyType":64,"phases":65,"briefSummary":68,"conditions":69,"keywords":24,"overallStatus":34,"whyStopped":24,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Oregon Health and Science University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Heavy Menstrual Bleeding","ACTIVE_COMPARATOR","Participants with heavy menstrual bleeding will provide daily samples of menstrual blood for a single cycle and undergo a single endometrial biopsy for HEEC culture.",[13],"Procedure: Sample Collection and Endometrial Biopsy",{"label":15,"type":10,"description":16,"interventionNames":17},"Regular Mensural Bleeding","Participants with normal menstrual bleeding will provide daily samples of menstrual blood for a single cycle and undergo a single endometrial biopsy for HEEC culture.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Sample Collection and Endometrial Biopsy","Participants will provide daily samples of menstrual blood for a single cycle and undergo a single endometrial biopsy for HEEC culture.",[9,15],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Women's Health Research Unit Department of Ob\u002FGyn","CONTACT","503-494-3666","whru@ohsu.edu",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":24},"OHSU","RECRUITING","Portland","Oregon","97239","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-122.67621,45.52345,{"lat":44,"lon":43},{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Bannowb","Principal Investigator","100505547","phase-1-pai-1-tpa-tfpi-and-heecs-in-uterine-hemostasis-100505547",false,"NCT05862805","PAI-1, tPA, TFPI and HEECs in Uterine Hemostasis","The Role of Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA), Tissue Factor Pathway Inhibitor (TFPI), and Endometrial Endothelial Cells in Uterine Hemostasis in Humans","Inclusion Criteria:\n\n* Regularly menstruating participants between 18-45 years of age\n\nExclusion Criteria:\n\n* Pregnancy within 3 months of enrollment\n* Lactating at the time of enrollment\n* Hormonal contraceptive use or use of the copper intrauterine device (IUD)\n* Antifibrinolytic use\n* Inherited or acquired bleeding disorder or anticoagulant use\n* Known structural cause of HMB\n* Inability to complete PBACs\n* Unwilling to refrain from sexual intercourse for the two weeks prior to endometrial biopsy",true,"FEMALE","18 Years","45 Years",{"count":62,"type":63},70,"ESTIMATED","INTERVENTIONAL",[66,67],"PHASE1","PHASE2","The purpose of the study is to learn more about the role of blood clotting factor proteins and cells in menstrual (period) bleeding. The investigators are hoping to identify differences in these proteins and cells in the menstrual blood of individuals with heavy periods compared to menstruating individuals who do not have heavy periods.",[70],"Menstrual Bleeding, Heavy","2024-08-16",{"date":73,"type":74},"2024-08-19","ACTUAL",{"date":76,"type":74},"2023-07-12",{"date":78,"type":63},"2026-07",{"name":5,"class":6},1]