[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100443396":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":23,"locations":32,"responsibleParty":51,"collaborators":22,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":22,"enrollmentInfo":63,"targetDuration":22,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":35,"whyStopped":22,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Peter MacCallum Cancer Centre, Australia","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"177Lu-DOTA-Octreotate + talazoparib","EXPERIMENTAL","Patients will receive 4 cycles of 177Lu-DOTA-Octreotate every 8 weeks, the last 3 cycles combined with talazoparib on days 2-6 of each cycle.",[13],"Drug: Talazoparib",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Talazoparib","During dose escalation, doses of talazoparib that can be administered are 0.1mg, 0.25mg, 0.5mg or 1mg oral daily. Talazoparib will be given on days 2-6 of each cycle of 177Lu-DOTA-Octreotate for cycles 2-4, every 8 weeks",[9],[21],"Combination product: 177Lu-DOTA-Octreotate",null,[24,29],{"name":25,"role":26,"phone":27,"phoneExt":22,"email":28},"Grace Kong","CONTACT","85595000","NMResearch@petermac.org",{"name":30,"role":26,"phone":31,"phoneExt":22,"email":22},"Research Manager","8559 6602",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Peter MacCallum Cancer Centre","RECRUITING","Melbourne","Victoria","3000","Australia","AU",{"type":42,"coordinates":43},"Point",[44,45],144.96332,-37.814,{"lat":45,"lon":44},[48],{"name":49,"role":26,"phone":50,"phoneExt":22,"email":28},"MC Research Manager","+61385596602",{"type":52,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100443396","phase-1-parp-inhibitor-with-177lu-dota-octreotate-prrt-in-patients-with-neuroendocrine-tumours-100443396",false,"NCT05053854","PARP Inhibitor With 177Lu-DOTA-Octreotate PRRT in Patients With Neuroendocrine Tumours","Phase 1 Trial of PARP Inhibitor Combined With 177Lu-DOTA-Octreotate Peptide Receptor Radionuclide Therapy (PRRT) in Patients With Metastatic NeuroEndocrine Tumor","PARLuNET","Inclusion Criteria:\n\n1. Patient must be \\> or equal to18 years of age and must have provided written informed consent.\n2. Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2\n3. Histologically confirmed Grade 2 NET, Ki-67 of 3-20%, from pancreatic or intestinal origin.\n4. Patient clinically suitable for PRRT\n5. Tumor SSR uptake on GaTate PET\u002FCT higher than liver activity, ≥ modified Krenning 3 score\n6. No discordant FDG-avid disease on FDG PET\u002FCT\n7. No evidence of significant uncorrected carcinoid heart disease\n8. Patients must be willing and able to comply with the protocol for the duration of the study including undergoing treatment, scheduled assessments\n9. Patients must have adequate bone marrow, hepatic and renal function defined as:\n\n   * Haemoglobin ≥100 g\u002FL\n   * Absolute neutrophil count ≥1.5x109\u002FL\n   * Platelets ≥150 x109\u002FL\n   * Total bilirubin ≤1.5 x upper limit of normal (ULN)\n   * Aspartate transaminase (AST) (SGOT) and alanine transaminase (ALT) (SGPT)\n\n     ≤2.5 x ULN if there is no evidence of liver metastasis or ≤5 x ULN in the presence of liver metastases.\n   * Albumin ≥ 30 g\u002FL\n   * Adequate renal function: eGFR ≥ 50 ml\u002Fmin\n\nExclusion Criteria:\n\n1. Surgery or radiotherapy within \\\u003C3 weeks of registration. Patients must have recovered from any effects of any major surgery.\n2. Any prior exposure to peptide receptor radionuclide therapy (177Lu, 111In or 90Y labelled), PARPi, immunotherapy\n3. Uncontrolled intercurrent illness that is likely to impede participation and \u002For compliance\n4. Other malignancies unless curatively treated with no evidence of disease within previous 3-years other than adequately treated non-melanoma skin cancer or melanoma in situ.\n5. Previous or current history of myelodysplastic syndrome\u002Facute myeloid leukemia\n6. Patients unable to swallow orally administered medications or with gastrointestinal disorders likely to interfere with the absorption of the study medication.\n7. Use of strong P-gp inhibitors (eg, dronedarone, quinidine, ranolazine, verapamil, ketoconazole, itraconazole), P-gp inducers (eg, rifampin, tipranavir\u002Fritonavir), or BCRP inhibitors (eg, elacridar \\[GF120918\\]) should be avoided.\n8. Participation in another clinical study with an investigational product or another systemic therapy administered in the last 3 weeks (except short acting SSA).","ALL","18 Years",{"count":64,"type":65},24,"ESTIMATED","INTERVENTIONAL",[68],"PHASE1","This phase 1 dose-escalation study is designed to evaluate the safety and tolerability of talazoparib in combination with 177Lu-DOTA-Octreotate peptide receptor radionuclide therapy (PRRT) in patients with metastatic pancreatic or midgut neuroendocrine tumour (NET).",[71],"Neuroendocrine Tumors",[73],"NET","2025-02-18",{"date":76,"type":77},"2025-02-20","ACTUAL",{"date":79,"type":77},"2021-12-08",{"date":81,"type":65},"2029-06-30",{"name":5,"class":6},1]