[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100554409":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":40,"centralContacts":44,"locations":49,"responsibleParty":64,"collaborators":39,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":39,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":39,"enrollmentInfo":75,"targetDuration":39,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":52,"whyStopped":39,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Yale University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nurse Administered Acetaminophen","ACTIVE_COMPARATOR","Participants will receive acetaminophen pills 650 mg every 4 hours as needed (PRN) administered by nurse per standard of care",[13],"Drug: Acetaminophen 650 mg Oral Tablet",{"label":15,"type":16,"description":17,"interventionNames":18},"CADD pump Administered Acetaminophen (Participant Controlled)","EXPERIMENTAL","Participants will receive a CADD pump primed and programmed to deliver 650 mg liquid acetaminophen into a medication cup every 4 hours as needed (PRN).",[19,20],"Drug: Acetaminophen 650mg Liquid","Device: CADD pump",[22,29,34],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","Acetaminophen 650 mg Oral Tablet","650 mg pills",[9],[28],"Tylenol",{"type":23,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Acetaminophen 650mg Liquid","650 mg liquid",[15],[28],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"DEVICE","CADD pump","Primed and programmed to delivery 650 mg liquid acetaminophen into a medication cup every 4 hours as needed.",[15],null,[41],{"name":42,"affiliation":5,"role":43},"Jinlei Li, MD, PhD","PRINCIPAL_INVESTIGATOR",[45],{"name":42,"role":46,"phone":47,"phoneExt":39,"email":48},"CONTACT","475-434-4038","jinlei.li@yale.edu",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":39},"Yale New Haven Hospital at St. Raphael's Campus","RECRUITING","New Haven","Connecticut","06520","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-72.92816,41.30815,{"lat":62,"lon":61},{"type":65,"investigatorFullName":39,"investigatorTitle":39,"investigatorAffiliation":39,"oldNameTitle":39,"oldOrganization":39},"SPONSOR","100554409","phase-1-patient-controlled-administration-of-liquid-acetaminophen-100554409",false,"NCT06498713","Patient Controlled Administration of Liquid Acetaminophen","Patient Controlled Self-Administration of Oral Liquid Medication: Acetaminophen Trial","Inclusion Criteria:\n\nParticipants\n\n* Adult patients older than 18 years old admitted to SRC for total shoulder and reverse total shoulder arthroplasty\n\nNurses\n\n* The nurse who will administer acetaminophen to a study patient.\n\nExclusion Criteria:\n\nParticipants\n\n* Pregnant patient\n* Patients that cannot swallow pills or cannot take liquid (for example due to risk of aspiration)\n* Emergency surgery\n* Chronic pain\n* On home opioids, any other pain modulating medications including benzodiazepine, Neurontin, ketamine.\n* Past medical or social history of substance abuse disorder, including ethanol misuse disorder, marijuana misuse disorder\n* History of any psychiatric disorders including anxiety, depression, any cognitive dysfunction\n* Any patients who cannot provide informed consents on their own (those who would need Legally Authorized Representatives (LARs) or surrogates)\n* Liver dysfunction limiting amount of safe oral acetaminophen\n* baseline hyperbilirubinemia (ex: chronic liver disease, Gilbert's)\n* patients unable to take PO\n* Patients with neurologic, neuromuscular, or movement disorders unable to drink from a cup.\n\nNurses\n\n* any nurse who is not involved in the direct care of a study patient, or who is not comfortable with setting up the PCA pump.","ALL","18 Years",{"count":76,"type":77},24,"ESTIMATED","INTERVENTIONAL",[80],"PHASE1","This is a proof of concept pilot study investigating the feasibility and acceptability of patient controlled oral medication administration, using the commonly used and low risk medication in the hospital, oral acetaminophen.",[83,84],"Pain","Pain, Postoperative",[86],"Pain Management","2026-06-17",{"date":89,"type":90},"2026-06-18","ACTUAL",{"date":92,"type":90},"2024-11-19",{"date":94,"type":77},"2026-12",{"name":5,"class":6},1]