[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100458121":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":30,"locations":38,"responsibleParty":353,"collaborators":16,"id":355,"slug":356,"hasResults":357,"nctId":358,"briefTitle":359,"officialTitle":360,"acronym":16,"eligibilityCriteria":361,"healthyVolunteers":357,"sex":362,"minAge":363,"maxAge":16,"enrollmentInfo":364,"targetDuration":16,"studyType":367,"phases":368,"briefSummary":370,"conditions":371,"keywords":378,"overallStatus":41,"whyStopped":16,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":396},{"fullName":5,"class":6},"Bristol-Myers Squibb","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase 1\u002F1B","EXPERIMENTAL","Dose Escalation\u002FEvaluation",[13],"Drug: MRTX1719",{"label":15,"type":10,"description":16,"interventionNames":17},"Phase 1b Sub-studies 1-4",null,[13],{"label":19,"type":10,"description":16,"interventionNames":20},"Phase 1b Sub-study 5",[13],[22],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":16},"DRUG","MRTX1719","MRTX1719 is a potent PRMT5-MTA inhibitor. Specified dose on specified days",[9,15,19],[28],{"name":5,"affiliation":5,"role":29},"STUDY_DIRECTOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":16,"email":35},"BMS Clinical Trials Contact Center www.BMSClinicalTrials.com","CONTACT","855-907-3286","Clinical.Trials@bms.com",{"name":37,"role":33,"phone":16,"phoneExt":16,"email":16},"First line of the email MUST contain the NCT# and Site #.",[39,57,71,84,97,109,120,134,147,160,174,188,200,213,220,233,241,255,268,281,293,305,318,332,342],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Mayo Clinic","RECRUITING","Phoenix","Arizona","85054-4502","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-112.07404,33.44838,{"lat":51,"lon":50},[54],{"name":55,"role":33,"phone":56,"phoneExt":16,"email":16},"Tanios Bekaii-Saab, Site 113","480-301-8000",{"facility":58,"status":41,"city":59,"state":60,"zip":61,"country":45,"countryCode":46,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Sarah Cannon Research Institute (SCRI) - HealthONE Location","Denver","Colorado","80218-1238",{"type":48,"coordinates":63},[64,65],-104.9847,39.73915,{"lat":65,"lon":64},[68],{"name":69,"role":33,"phone":70,"phoneExt":16,"email":16},"Sreenivasa Chandana, Site 106","269-993-6056",{"facility":72,"status":41,"city":73,"state":60,"zip":74,"country":45,"countryCode":46,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Rocky Mountain Cancer Centers, LLP - Oncology","Lone Tree","80124",{"type":48,"coordinates":76},[77,78],-104.8863,39.55171,{"lat":78,"lon":77},[81],{"name":82,"role":33,"phone":83,"phoneExt":16,"email":16},"Robert Jotte, Site 109","303-430-2700",{"facility":40,"status":41,"city":85,"state":86,"zip":87,"country":45,"countryCode":46,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"Jacksonville","Florida","32224",{"type":48,"coordinates":89},[90,91],-81.65565,30.33218,{"lat":91,"lon":90},[94],{"name":95,"role":33,"phone":96,"phoneExt":16,"email":16},"Hani Babiker, Site 114","000000000",{"facility":98,"status":41,"city":99,"state":86,"zip":100,"country":45,"countryCode":46,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Sarah Cannon Research Institute at Florida Cancer Specialists","Orlando","32827",{"type":48,"coordinates":102},[103,104],-81.37924,28.53834,{"lat":104,"lon":103},[107],{"name":108,"role":33,"phone":16,"phoneExt":16,"email":16},"Cesar Perez Batista, Site 121",{"facility":110,"status":111,"city":112,"state":113,"zip":114,"country":45,"countryCode":46,"cosmosGeoPoint":115,"geoPoint":119,"contacts":16},"Local Institution - 124","WITHDRAWN","Chicago","Illinois","60637",{"type":48,"coordinates":116},[117,118],-87.65005,41.85003,{"lat":118,"lon":117},{"facility":121,"status":41,"city":122,"state":123,"zip":124,"country":45,"countryCode":46,"cosmosGeoPoint":125,"geoPoint":129,"contacts":130},"Dana-Farber Cancer Institute","Brookline","Massachusetts","02251",{"type":48,"coordinates":126},[127,128],-71.12116,42.33176,{"lat":128,"lon":127},[131],{"name":132,"role":33,"phone":133,"phoneExt":16,"email":16},"Pasi Janne, Site 103","617-632-6036",{"facility":135,"status":41,"city":136,"state":137,"zip":138,"country":45,"countryCode":46,"cosmosGeoPoint":139,"geoPoint":143,"contacts":144},"Cancer and Hematology Centers of Western Michigan","Norton Shores","Michigan","49444",{"type":48,"coordinates":140},[141,142],-86.26395,43.1689,{"lat":142,"lon":141},[145],{"name":146,"role":33,"phone":70,"phoneExt":16,"email":16},"Sreenivasa Chandana, Site 131",{"facility":40,"status":41,"city":148,"state":149,"zip":150,"country":45,"countryCode":46,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"Rochester","Minnesota","55905",{"type":48,"coordinates":152},[153,154],-92.4699,44.02163,{"lat":154,"lon":153},[157],{"name":158,"role":33,"phone":159,"phoneExt":16,"email":16},"Lei Deng, Site 112","206-606-4801",{"facility":161,"status":41,"city":162,"state":163,"zip":164,"country":45,"countryCode":46,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"Rutgers Cancer Institute of New Jersey","New Brunswick","New Jersey","08901",{"type":48,"coordinates":166},[167,168],-74.45182,40.48622,{"lat":168,"lon":167},[171],{"name":172,"role":33,"phone":173,"phoneExt":16,"email":16},"Kristen Spencer, Site 127","732-235-2465",{"facility":175,"status":176,"city":177,"state":178,"zip":179,"country":45,"countryCode":46,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"Local Institution - 129","NOT_YET_RECRUITING","Mineola","New York","11501",{"type":48,"coordinates":181},[182,183],-73.64068,40.74927,{"lat":183,"lon":182},[186],{"name":187,"role":33,"phone":16,"phoneExt":16,"email":16},"Site 129",{"facility":189,"status":41,"city":178,"state":178,"zip":190,"country":45,"countryCode":46,"cosmosGeoPoint":191,"geoPoint":195,"contacts":196},"David H Koch, Memorial Sloan Kettering Cancer Center","10021",{"type":48,"coordinates":192},[193,194],-74.00597,40.71427,{"lat":194,"lon":193},[197],{"name":198,"role":33,"phone":199,"phoneExt":16,"email":16},"Kathryn Arbour, Site 104","646-608-3792",{"facility":201,"status":41,"city":202,"state":178,"zip":203,"country":45,"countryCode":46,"cosmosGeoPoint":204,"geoPoint":208,"contacts":209},"New york cancer and blood specialists - Oncology","Port Jefferson Station","11776",{"type":48,"coordinates":205},[206,207],-73.04733,40.92538,{"lat":207,"lon":206},[210],{"name":211,"role":33,"phone":212,"phoneExt":16,"email":16},"Richard Zuniga, Site 101","631751050",{"facility":201,"status":41,"city":202,"state":178,"zip":203,"country":45,"countryCode":46,"cosmosGeoPoint":214,"geoPoint":216,"contacts":217},{"type":48,"coordinates":215},[206,207],{"lat":207,"lon":206},[218],{"name":219,"role":33,"phone":16,"phoneExt":16,"email":16},"Richard Zuniga, Site 115",{"facility":221,"status":41,"city":222,"state":223,"zip":224,"country":45,"countryCode":46,"cosmosGeoPoint":225,"geoPoint":229,"contacts":230},"University of North Carolina - Gastroenterology and Hepatology","Chapel Hill","North Carolina","27599",{"type":48,"coordinates":226},[227,228],-79.05584,35.9132,{"lat":228,"lon":227},[231],{"name":232,"role":33,"phone":16,"phoneExt":16,"email":16},"Shetal Patel, Site 107",{"facility":234,"status":41,"city":222,"state":223,"zip":224,"country":45,"countryCode":46,"cosmosGeoPoint":235,"geoPoint":237,"contacts":238},"University of North Carolina",{"type":48,"coordinates":236},[227,228],{"lat":228,"lon":227},[239],{"name":240,"role":33,"phone":16,"phoneExt":16,"email":16},"Shetal Patel, Site 125",{"facility":242,"status":41,"city":243,"state":244,"zip":245,"country":45,"countryCode":46,"cosmosGeoPoint":246,"geoPoint":250,"contacts":251},"Vanderbilt - Ingram Cancer Center","Nashville","Tennessee","37232-5505",{"type":48,"coordinates":247},[248,249],-86.78444,36.16589,{"lat":249,"lon":248},[252],{"name":253,"role":33,"phone":254,"phoneExt":16,"email":16},"Elizabeth Davis, Site 132","206-341-1111",{"facility":256,"status":41,"city":257,"state":258,"zip":259,"country":45,"countryCode":46,"cosmosGeoPoint":260,"geoPoint":264,"contacts":265},"Ut Southwestern","Dallas","Texas","75235",{"type":48,"coordinates":261},[262,263],-96.80667,32.78306,{"lat":263,"lon":262},[266],{"name":267,"role":33,"phone":16,"phoneExt":16,"email":16},"Salwan Al Mutar, Site 120",{"facility":269,"status":41,"city":270,"state":258,"zip":271,"country":45,"countryCode":46,"cosmosGeoPoint":272,"geoPoint":276,"contacts":277},"Texas Oncology - DFW","Fort Worth","76104",{"type":48,"coordinates":273},[274,275],-97.32085,32.72541,{"lat":275,"lon":274},[278],{"name":279,"role":33,"phone":280,"phoneExt":16,"email":16},"Andrew Paulson, Site 111","214-370-1000",{"facility":282,"status":41,"city":283,"state":258,"zip":284,"country":45,"countryCode":46,"cosmosGeoPoint":285,"geoPoint":289,"contacts":290},"MDACC","Houston","77030",{"type":48,"coordinates":286},[287,288],-95.36327,29.76328,{"lat":288,"lon":287},[291],{"name":292,"role":33,"phone":16,"phoneExt":16,"email":16},"Jordi Ahnert, Site 105",{"facility":294,"status":41,"city":295,"state":258,"zip":296,"country":45,"countryCode":46,"cosmosGeoPoint":297,"geoPoint":301,"contacts":302},"South Texas Accelerated Research Therapeutics","San Antonio","78229",{"type":48,"coordinates":298},[299,300],-98.49363,29.42412,{"lat":300,"lon":299},[303],{"name":304,"role":33,"phone":16,"phoneExt":16,"email":16},"Kyriakos Papadopoulos, Site 102",{"facility":306,"status":41,"city":307,"state":258,"zip":308,"country":45,"countryCode":46,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"Texas Oncology, P.A. - Oncology","Tyler","78503",{"type":48,"coordinates":310},[311,312],-95.30106,32.35126,{"lat":312,"lon":311},[315],{"name":316,"role":33,"phone":317,"phoneExt":16,"email":16},"Donald Richards, Site 110","903-579-9800",{"facility":319,"status":41,"city":320,"state":321,"zip":322,"country":45,"countryCode":46,"cosmosGeoPoint":323,"geoPoint":327,"contacts":328},"Virginia Cancer Specialists, PC","Fairfax","Virginia","22031",{"type":48,"coordinates":324},[325,326],-77.30637,38.84622,{"lat":326,"lon":325},[329],{"name":330,"role":33,"phone":331,"phoneExt":16,"email":16},"Alexander Spira, Site 122","703-280-5390",{"facility":333,"status":111,"city":334,"state":335,"zip":336,"country":45,"countryCode":46,"cosmosGeoPoint":337,"geoPoint":341,"contacts":16},"Local Institution - 134","Seattle","Washington","98109",{"type":48,"coordinates":338},[339,340],-122.33207,47.60621,{"lat":340,"lon":339},{"facility":343,"status":344,"city":345,"state":346,"zip":347,"country":45,"countryCode":46,"cosmosGeoPoint":348,"geoPoint":352,"contacts":16},"Local Institution - 108","COMPLETED","Milwaukee","Wisconsin","53226",{"type":48,"coordinates":349},[350,351],-87.90647,43.0389,{"lat":351,"lon":350},{"type":354,"investigatorFullName":16,"investigatorTitle":16,"investigatorAffiliation":16,"oldNameTitle":16,"oldOrganization":16},"SPONSOR","100458121","phase-1-phase-1-study-of-mrtx1719-in-solid-tumors-with-mtap-deletion-100458121",false,"NCT05245500","Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion","A Phase 1 Multiple Expansion Cohort Trial of MRTX1719 in Patients With Advanced Solid Tumors With Homozygous MTAP Deletion","Inclusion Criteria\n\n* Histologically confirmed diagnosis of a solid tumor malignancy with homozygous deletion of the MTAP gene detected in tumor tissue.\n* Unresectable or metastatic disease.\n* Presence of a tumor lesion amenable to mandatory biopsy for pharmacodynamic evaluation at baseline and on-study unless Sponsor-confirmed as medically unsafe or infeasible.\n* Age ≥ 18 years.\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.\n* Adequate organ function.\n\nExclusion Criteria\n\n* Prior treatment with a PRMT5 or MAT2A inhibitor therapy.\n* Active brain metastases or carcinomatous meningitis.\n* History of significant hemoptysis or hemorrhage within 4 weeks of the first dose of study treatment.\n* Major surgery within 4 weeks of first dose of study treatment.\n* History of intestinal disease, inflammatory bowel disease, major gastric surgery, or other gastrointestinal conditions (eg, uncontrolled nausea, vomiting, malabsorption syndrome) likely to alter absorption of study treatment or result in inability to swallow oral medications.\n* Cardiac abnormalities.\n* Other protocol-defined Inclusion\u002FExclusion criteria apply.","ALL","18 Years",{"count":365,"type":366},336,"ESTIMATED","INTERVENTIONAL",[369],"PHASE1","This is a Phase 1, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable or metastatic solid tumor malignancy with homozygous deletion of the MTAP gene.",[372,373,374,375,376,377],"Mesothelioma","Non Small Cell Lung Cancer","Malignant Peripheral Nerve Sheath Tumors","Solid Tumor","Pancreatic Adenocarcinoma","Advanced Solid Tumor",[379,372,373,374,375,380,381,382,383,384,385,377,386],"MTAP Deletion","MTAP","Malignant","Pancreatic adenocarcinoma","Pancreas Cancer","PRMT5","Synthetic Lethality","NSCLC","2025-12-04",{"date":389,"type":390},"2025-12-05","ACTUAL",{"date":392,"type":390},"2022-06-09",{"date":394,"type":366},"2027-12-10",{"name":5,"class":6},25]