[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100532907":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":194,"collaborators":25,"id":196,"slug":197,"hasResults":198,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":25,"eligibilityCriteria":202,"healthyVolunteers":198,"sex":203,"minAge":204,"maxAge":25,"enrollmentInfo":205,"targetDuration":25,"studyType":208,"phases":209,"briefSummary":211,"conditions":212,"keywords":219,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":239},{"fullName":5,"class":6},"AstraZeneca","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"NT-112","EXPERIMENTAL","Part A Dose Escalation and Part B Dose Expansion of NT-112",[13],"Biological: NT-112: Autologous, engineered T Cells targeting KRAS G12D",{"label":15,"type":10,"description":16,"interventionNames":17},"AZD0240","Part A Dose Escalation and Part B Dose Expansion of AZD0240",[18],"Biological: AZD0240: Autologous, engineered T Cells targeting KRAS G12D",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BIOLOGICAL","NT-112: Autologous, engineered T Cells targeting KRAS G12D","NT-112 targets KRAS G12D in the context of HLA-C\\*08:02",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"AZD0240: Autologous, engineered T Cells targeting KRAS G12D","AZD0240 targets KRAS G12D in the context of HLA-A\\*11:01 or HLA-A\\*11:02",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"AstraZeneca Clinical Study Information Center","CONTACT","1-877-240-9479","information.center@astrazeneca.com",[37,51,59,67,76,85,94,103,112,120,125,134,143,151,160,169,177,185],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":25},"Research Site","RECRUITING","Duarte","California","91010","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-117.97729,34.13945,{"lat":49,"lon":48},{"facility":38,"status":39,"city":52,"state":41,"zip":53,"country":43,"countryCode":44,"cosmosGeoPoint":54,"geoPoint":58,"contacts":25},"Los Angeles","90095",{"type":46,"coordinates":55},[56,57],-118.24368,34.05223,{"lat":57,"lon":56},{"facility":38,"status":39,"city":60,"state":41,"zip":61,"country":43,"countryCode":44,"cosmosGeoPoint":62,"geoPoint":66,"contacts":25},"Newport Beach","92663",{"type":46,"coordinates":63},[64,65],-117.92895,33.61891,{"lat":65,"lon":64},{"facility":38,"status":39,"city":68,"state":69,"zip":70,"country":43,"countryCode":44,"cosmosGeoPoint":71,"geoPoint":75,"contacts":25},"Jacksonville","Florida","32224",{"type":46,"coordinates":72},[73,74],-81.65565,30.33218,{"lat":74,"lon":73},{"facility":38,"status":39,"city":77,"state":78,"zip":79,"country":43,"countryCode":44,"cosmosGeoPoint":80,"geoPoint":84,"contacts":25},"Chicago","Illinois","60637",{"type":46,"coordinates":81},[82,83],-87.65005,41.85003,{"lat":83,"lon":82},{"facility":38,"status":39,"city":86,"state":87,"zip":88,"country":43,"countryCode":44,"cosmosGeoPoint":89,"geoPoint":93,"contacts":25},"Westwood","Kansas","66205",{"type":46,"coordinates":90},[91,92],-94.6169,39.04056,{"lat":92,"lon":91},{"facility":38,"status":39,"city":95,"state":96,"zip":97,"country":43,"countryCode":44,"cosmosGeoPoint":98,"geoPoint":102,"contacts":25},"Boston","Massachusetts","02115",{"type":46,"coordinates":99},[100,101],-71.05977,42.35843,{"lat":101,"lon":100},{"facility":38,"status":39,"city":104,"state":105,"zip":106,"country":43,"countryCode":44,"cosmosGeoPoint":107,"geoPoint":111,"contacts":25},"St Louis","Missouri","63110",{"type":46,"coordinates":108},[109,110],-90.19789,38.62727,{"lat":110,"lon":109},{"facility":38,"status":39,"city":113,"state":113,"zip":114,"country":43,"countryCode":44,"cosmosGeoPoint":115,"geoPoint":119,"contacts":25},"New York","10016",{"type":46,"coordinates":116},[117,118],-74.00597,40.71427,{"lat":118,"lon":117},{"facility":38,"status":39,"city":113,"state":113,"zip":121,"country":43,"countryCode":44,"cosmosGeoPoint":122,"geoPoint":124,"contacts":25},"10065",{"type":46,"coordinates":123},[117,118],{"lat":118,"lon":117},{"facility":38,"status":39,"city":126,"state":127,"zip":128,"country":43,"countryCode":44,"cosmosGeoPoint":129,"geoPoint":133,"contacts":25},"Portland","Oregon","97213",{"type":46,"coordinates":130},[131,132],-122.67621,45.52345,{"lat":132,"lon":131},{"facility":38,"status":39,"city":135,"state":136,"zip":137,"country":43,"countryCode":44,"cosmosGeoPoint":138,"geoPoint":142,"contacts":25},"Philadelphia","Pennsylvania","19107",{"type":46,"coordinates":139},[140,141],-75.16362,39.95238,{"lat":141,"lon":140},{"facility":38,"status":39,"city":144,"state":136,"zip":145,"country":43,"countryCode":44,"cosmosGeoPoint":146,"geoPoint":150,"contacts":25},"Pittsburgh","15237",{"type":46,"coordinates":147},[148,149],-79.99589,40.44062,{"lat":149,"lon":148},{"facility":38,"status":39,"city":152,"state":153,"zip":154,"country":43,"countryCode":44,"cosmosGeoPoint":155,"geoPoint":159,"contacts":25},"Nashville","Tennessee","37203",{"type":46,"coordinates":156},[157,158],-86.78444,36.16589,{"lat":158,"lon":157},{"facility":38,"status":39,"city":161,"state":162,"zip":163,"country":43,"countryCode":44,"cosmosGeoPoint":164,"geoPoint":168,"contacts":25},"Dallas","Texas","75246",{"type":46,"coordinates":165},[166,167],-96.80667,32.78306,{"lat":167,"lon":166},{"facility":38,"status":39,"city":170,"state":162,"zip":171,"country":43,"countryCode":44,"cosmosGeoPoint":172,"geoPoint":176,"contacts":25},"Galveston","77555",{"type":46,"coordinates":173},[174,175],-94.7977,29.30135,{"lat":175,"lon":174},{"facility":38,"status":39,"city":178,"state":162,"zip":179,"country":43,"countryCode":44,"cosmosGeoPoint":180,"geoPoint":184,"contacts":25},"Houston","77030",{"type":46,"coordinates":181},[182,183],-95.36327,29.76328,{"lat":183,"lon":182},{"facility":38,"status":39,"city":186,"state":187,"zip":188,"country":43,"countryCode":44,"cosmosGeoPoint":189,"geoPoint":193,"contacts":25},"Milwaukee","Wisconsin","53226",{"type":46,"coordinates":190},[191,192],-87.90647,43.0389,{"lat":192,"lon":191},{"type":195,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100532907","phase-1-phase-1-study-to-investigate-tcrts-kras-mutation-in-unresectable-advanced-andor-metastatic-solid-tumors-100532907",false,"NCT06218914","Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and\u002For Metastatic Solid Tumors","Open-label, Phase 1, Multi-Center Master Protocol to Evaluate the Safety and Preliminary Anti-Tumor Activity of TCR-engineered T Cells Recognizing KRAS Mutations in Adult Subjects With Unresectable, Advanced, and\u002For Metastatic Solid Tumors","Key Inclusion Criteria:\n\n* Age ≥18 years\n* Diagnosed with NSCLC, Colorectal adenocarcinoma, Pancreatic adenocarcinoma, Endometrial Cancer or any other solid tumor\n* Tumors must harbor a KRAS G12D variant mutation and subject must be HLA-C\\*08:02 positive, HLA-A\\*11:01 or HLA-A\\*11:02 positive in at least one allele\n* Subject has advanced solid cancer, defined as unresectable, advanced, and\u002For metastatic disease (Stage III or IV) after at least 1 line of approved systemic standard of care (SOC) treatment regimen and for which there are no available curative treatment options.\n* Presence of at least 1 measurable lesion per RECIST v1.1\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 at the time of enrollment\n\nKey Exclusion Criteria:\n\n* Any other primary malignancy within the 3 years prior to enrollment (except for non-melanoma skin cancer, carcinoma in situ (eg, cervix, bladder, breast) or low-grade prostate cancer\n* Known, active primary central nervous system (CNS) malignancy\n* History of prior adoptive cell and gene therapy, allogeneic stem cell transplant or solid organ transplantation.\n* History of stroke or transient ischemic attack within the 12 months prior to enrollment.\n* History of clinically significant cardiac disease within the 6 months prior to enrollment or heart failure at any time prior to enrollment.\n* Systemic therapy within at least 2 weeks or 3 half-lives, whichever is shorter, prior to enrollment.\n* Any form of primary immunodeficiency.\n* Active immune-mediated disease requiring systemic steroids or other immunosuppressive treatment (except if related to prior checkpoint inhibitor therapy)\n* Female of childbearing potential who is lactating or breast feeding at the time of enrollment\n* Prior treatment with pan-KRAS or KRAS G12D targeting agents unless presence of KRAS G12D mutation is confirmed after the completion of treatment with pan-KRAS or KRAS G12D targeting agents.","ALL","18 Years",{"count":206,"type":207},108,"ESTIMATED","INTERVENTIONAL",[210],"PHASE1","Phase I Study, a master protocol to investigate TCR-Engineered T cells recognizing KRAS mutations in adult subjects with Unresectable, Advanced, and\u002For Metastatic Solid Tumors.",[213,214,215,216,217,218],"Non-small Cell Lung Cancer","Colorectal Carcinoma","Pancreatic Ductal Adenocarcinoma","Endometrial Cancer","Solid Tumor, Adult","KRAS G12D",[220,221,218,222,223,224,225,226,215,227,228,229],"TCR-T cell therapy","KRAS","Autologous","PDAC","NSCLC","Colorectal Cancer","Solid tumors","HLA-C*08:02","HLA-A*11:01","HLA-A*11:02","2026-06-30",{"date":232,"type":233},"2026-07-01","ACTUAL",{"date":235,"type":233},"2024-03-22",{"date":237,"type":207},"2043-11-18",{"name":5,"class":6},18]