[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100411889":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":27,"locations":34,"responsibleParty":52,"collaborators":39,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":39,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":39,"enrollmentInfo":63,"targetDuration":39,"studyType":66,"phases":67,"briefSummary":70,"conditions":71,"keywords":39,"overallStatus":37,"whyStopped":39,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"MegaPro Biomedical Co. Ltd.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"MPB-1734, single arm, dose escalation","EXPERIMENTAL","intravenous, once per 3 weeks, starting at 10 mg\u002Fm˄2",[13],"Drug: MPB-1734",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","MPB-1734","Administered once daily in a 21-day cycle",[9],[21],"DMB025",[23],{"name":24,"affiliation":25,"role":26},"Muh-Hwa Yang, MD","Taipei Veterans General Hospital, Taiwan","PRINCIPAL_INVESTIGATOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Summer Liao, MS","CONTACT","+886-3-5910360","231","thliao@megaprobio.com",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Taipei Veterans General Hospital","RECRUITING","Taipei",null,"112","Taiwan","TW",{"type":44,"coordinates":45},"Point",[46,47],121.52639,25.05306,{"lat":47,"lon":46},[50],{"name":51,"role":30,"phone":39,"phoneExt":39,"email":39},"Iris Chang",{"type":53,"investigatorFullName":39,"investigatorTitle":39,"investigatorAffiliation":39,"oldNameTitle":39,"oldOrganization":39},"SPONSOR","100411889","phase-1-phase-12a-study-of-mpb-1734-in-patients-with-advanced-solid-tumors-100411889",false,"NCT04643418","Phase 1\u002F2a Study of MPB-1734 in Patients With Advanced Solid Tumors","Phase 1\u002F2a Dose-ranging, Safety, Pharmacokinetics, and Preliminary Efficacy Study of MPB-1734 in Patients With Advanced Solid Tumors in Part 1 and With Selected Solid Tumors in Part 2","Inclusion Criteria:\n\n1. Signed informed consent in the local language prior to any study-mandated procedure.\n2. Male or female patients at least 18 years of age, at the time of informed consent.\n3. Male or nonpregnant and nonlactating female patients with pathologically confirmed, measurable solid tumor lesions (Response Evaluation Criteria in Solid Tumors version 1.1 \\[RECIST 1.1\\]) that are unresectable, and standard therapy able to provide clinical benefit does not exist or is no longer effective.\n4. Eastern Cooperative Oncology Group Performance Status ≤2.\n5. Patients have recovered from the acute toxicity of previous therapies (peripheral sensory neuropathy recovered to ≤Grade 2) except alopecia, and:\n\n   * At least 4 weeks have elapsed since completing surgery, endocrine therapy, tyrosine kinase inhibitor therapy, immunotherapy, radiotherapy, chemotherapy, and\u002For\n   * At least 6 weeks have elapsed since completing chemotherapy with nitrosoureas, melphalan, and\u002For mitomycin C, and\u002For\n   * At least 6 weeks have elapsed since completing cranial radiotherapy.\n6. Life expectancy of greater than 12 weeks.\n7. Ability to communicate well with the investigator, in the local language, and to understand and comply with the requirements of the study.\n\nExclusion Criteria:\n\n1. Peripheral sensory neuropathy \\>Grade 2 (CTCAE version 5.0) at baseline.\n2. Patients requiring immediate palliative treatment of any kind including surgery and\u002For radiotherapy.\n3. Serum bilirubin \\>1.5× ULN.\n4. AST and\u002For ALT \\>2.5× ULN if no liver involvement, OR AST and\u002For ALT \\>5× ULN with liver involvement.\n5. Serum creatinine \\>1.5× ULN, and\u002For a creatinine clearance of \\\u003C50 mL\u002Fmin calculated by Cockcroft Gault.\n6. QTc prolongation defined as a QTc with Framingham correction greater than or equal to 470 ms, or significant electrocardiogram (ECG) abnormalities.\n7. Known hypersensitivity to taxanes or any excipients of the drug formulation.\n8. Female patients who are pregnant, breast-feeding, or planning to become pregnant during the study.\n9. Untreated and\u002For uncontrolled central nervous system metastases.\n10. Patients with brain tumors, primary or metastatic.\n11. Patients taking concomitant medications anticipated to result in drug-drug interactions.","ALL","18 Years",{"count":64,"type":65},81,"ESTIMATED","INTERVENTIONAL",[68,69],"PHASE1","PHASE2","This is a first-in-human (FIH), multicenter, open-label, uncontrolled, Phase 1\u002F2a study with dose escalation in patients with advanced solid tumors (Part 1) and cohorts of up to 15 patients per selected indication (Part 2). The solid tumor types in Part 2 will be decided by the sponsor prior to the start of Part 2, but not be solely based on the efficacy results in Part 1.",[72],"Solid Tumor, Unspecified, Adult","2025-10-30",{"date":75,"type":76},"2025-11-03","ACTUAL",{"date":78,"type":76},"2022-03-08",{"date":80,"type":65},"2025-12",{"name":5,"class":6},1]